2012年5月
Bifidobacterial Enzymes Involved in the Metabolism of Human Milk Oligosaccharides
ADVANCES IN NUTRITION
- 巻
- 3
- 号
- 3
- 開始ページ
- 422S
- 終了ページ
- 429S
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3945/an.111.001420
- 出版者・発行元
- AMER SOC NUTRITION-ASN
Intestinal colonization of bifidobacteria is important for the health of infants. Human milk oligosaccharides (HMO) have been identified as growth factors for bifidobacteria. Recently, a bifidobacterial enzymatic system to metabolize HMO was identified. 1,3-beta-Galactosyl-N-acetylhexosamine phosphorylase (GLNBP, EC 2.4.1.211), which catalyzes the reversible phosphorolysis of galacto-N-biose (GNB) (Gal beta 1,-> 3GalNAc)] and lacto-N-biose I (LNB) (Gal beta 1 -> 3GlcNAc), is a key enzyme to explain the metabolism of HMO. Infant-type bifidobacteria possess the intracellular pathway to specifically metabolize GNB and LNB (GNB/LNB pathway). Bifidobacterium bifidum possesses extracellular enzymes to liberate [NB from HMO. However, Bindobactenum longum subsp. infantis imports intact HMO to be hydrolyzed by intracellular enzymes. Bifidobacterial enzymes related to the metabolism of HMO are useful tools for preparing compounds related to HMO. For instance, LNB and GNB were produced from sucrose and GlcNAc/GalNAc in 1 pot using 4 bifidobacterial enzymes, including GLNBP. [NB is expected to be a selective bifidus factor for infant-type strains. Adv. Nutr. 3: 422S-429S, 2012.
- リンク情報
-
- DOI
- https://doi.org/10.3945/an.111.001420
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/22585921
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000313220000022&DestApp=WOS_CPL
- URL
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866789452&origin=inward
- ID情報
-
- DOI : 10.3945/an.111.001420
- ISSN : 2161-8313
- PubMed ID : 22585921
- SCOPUS ID : 84866789452
- Web of Science ID : WOS:000313220000022