2007年10月
Identification of N-acetylhexosamine 1-kinase in the complete lacto-N-biose I/Galacto-N-Biose metabolic pathway in Bifidobactetium longum
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- ,
- 巻
- 73
- 号
- 20
- 開始ページ
- 6444
- 終了ページ
- 6449
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1128/AEM.01425-07
- 出版者・発行元
- AMER SOC MICROBIOLOGY
We have determined the functions of the enzymes encoded by the lnpB, InpC, and InpD genes, located downstream of the lacto-N-biose phosphorylase gene (lnpA), in Bifidobacterium longum JCM1217. The lnpB gene encodes a novel kinase, N-acetylhexosamine 1-kinase, which produces N-acetylhexosamine I-phosphate; the InpC gene encodes UDP-glucose hexose 1-phosphate uridylyltransferase, which is also active on N-acetylhexosamine I-phosphate; and the lnpD gene encodes a UDP-glucose 4-epimerase, which is active on both UDPgalactose and UDP-N-acetylgalactosamine. These results suggest that the gene operon lnpABCD encodes a previously undescribed lacto-N-biose I/galacto-N-biose metabolic pathway that is involved in the intestinal colonization of bifidobacteria and that utilizes lacto-N-biose I from human milk oligosaccharides or galacto-N-biose from mucin sugars.
- リンク情報
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- DOI
- https://doi.org/10.1128/AEM.01425-07
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/17720833
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000250248400015&DestApp=WOS_CPL
- URL
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=35448959649&origin=inward
- ID情報
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- DOI : 10.1128/AEM.01425-07
- ISSN : 0099-2240
- PubMed ID : 17720833
- SCOPUS ID : 35448959649
- Web of Science ID : WOS:000250248400015