論文

査読有り
2016年1月

Geniculo-Cortical Projection Diversity Revealed within the Mouse Visual Thalamus

PLOS ONE
  • Marcus N. Leiwe
  • ,
  • Aenea C. Hendry
  • ,
  • Andrew D. Bard
  • ,
  • Stephen J. Eglen
  • ,
  • Andrew S. Lowe
  • ,
  • Ian D. Thompson

11
1
開始ページ
e0144846
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0144846
出版者・発行元
PUBLIC LIBRARY SCIENCE

The mouse dorsal lateral geniculate nucleus (dLGN) is an intermediary between retina and primary visual cortex (V1). Recent investigations are beginning to reveal regional complexity in mouse dLGN. Using local injections of retrograde tracers into V1 of adult and neonatal mice, we examined the developing organisation of geniculate projection columns: the population of dLGN-V1 projection neurons that converge in cortex. Serial sectioning of the dLGN enabled the distribution of labelled projection neurons to be reconstructed and collated within a common standardised space. This enabled us to determine: the organisation of cells within the dLGN-V1 projection columns; their internal organisation (topology); and their order relative to V1 (topography). Here, we report parameters of projection columns that are highly variable in young animals and refined in the adult, exhibiting profiles consistent with shell and core zones of the dLGN. Additionally, such profiles are disrupted in adult animals with reduced correlated spontaneous activity during development. Assessing the variability between groups with partial least squares regression suggests that 4-6 cryptic lamina may exist along the length of the projection column. Our findings further spotlight the diversity of the mouse dLGN-an increasingly important model system for understanding the pre-cortical organisation and processing of visual information. Furthermore, our approach of using standardised spaces and pooling information across many animals will enhance future functional studies of the dLGN.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0144846
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26727264
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699701
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000367681500007&DestApp=WOS_CPL
URL
http://europepmc.org/abstract/med/26727264
URL
http://orcid.org/0000-0002-3493-7091
ID情報
  • DOI : 10.1371/journal.pone.0144846
  • ISSN : 1932-6203
  • ORCIDのPut Code : 28676104
  • PubMed ID : 26727264
  • PubMed Central 記事ID : PMC4699701
  • Web of Science ID : WOS:000367681500007

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