2016年
Drug-Induced Hypersensitivity Syndrome Caused by Carbamazepine Used for the Treatment of Trigeminal Neuralgia.
Case reports in dentistry
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- 巻
- 2016
- 号
- 開始ページ
- 4605231
- 終了ページ
- 4605231
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
An 88-year-old man was diagnosed with trigeminal neuralgia, and treatment of carbamazepine 200 mg/day was initiated. About 6 weeks later, the patient developed a skin rash accompanied by fever. He was admitted to hospital and diagnosed with drug-induced hypersensitivity syndrome (DIHS) caused by carbamazepine. Oral carbamazepine treatment was stopped, but blood tests showed acute liver and acute renal failure. Drug-induced lymphocyte stimulation test (DLST) for carbamazepine, human herpes virus-6 (HHV-6) IgG, and CMV-HRP were negative. Oral prednisolone therapy was begun 18 days later. The titer of HHV-6 IgG antibodies was then detected (640 times). Following treatment, liver and renal function improved and the erythema disappeared.
- リンク情報
- ID情報
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- ISSN : 2090-6447
- PubMed ID : 27885344
- PubMed Central 記事ID : PMC5112318