2002年5月
JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells
EMBO JOURNAL
- 巻
- 21
- 号
- 9
- 開始ページ
- 2159
- 終了ページ
- 2167
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1093/emboj/21.9.2159
- 出版者・発行元
- NATURE PUBLISHING GROUP
Defining signals that can support the self-renewal of multipotential hemopoietic progenitor cells (MHPCs) is pertinent to understanding leukemogenesis and may be relevant to developing stem cell-based therapies. Here we define a set of signals, JAK2 plus either c-kit or flt-3, which together can support extensive MHPC self-renewal. Phenotypically and functionally distinct populations of MHPCs were obtained, depending on which receptor tyrosine kinase, c-kit or flt-3, was activated. Self-renewal was abrogated in the absence of STAT5a/b, and in the presence of inhibitors targeting either the mitogen-activated protein kinase or phosphatidylinositol 3' kinase pathways. These findings suggest that a simple two-component signal can drive MHPC self-renewal.
- リンク情報
- ID情報
-
- DOI : 10.1093/emboj/21.9.2159
- ISSN : 0261-4189
- Web of Science ID : WOS:000175393700012