小沢学 (Manabu OZAWA) - マイポータル

基本情報

所属: 東京大学医科学研究所准教授

学位: 博士（農学）(筑波大学)

研究者番号: 80608787
J-GLOBAL ID: 201501032580866993
researchmap会員ID: B000246631

外部リンク: https://kaken.nii.ac.jp/d/r/80608787.ja.html

次世代に遺伝情報を伝えうる唯一の細胞系譜である生殖細胞の発生と維持について研究しています。

研究キーワード

研究分野

経歴

2016年12月 - 現在

東京大学, 医科学研究所, 准教授
2011年1月 - 2016年12月

東京大学, 医科学研究所, 助教
2009年4月 - 2011年1月

University of Florida, 日本学術振興会海外特別研究員
2008年1月 - 2009年4月

東京大学, 医科学研究所, 特別研究員
2005年4月 - 2008年1月

農業生物資源研究所, 日本学術振興会 PD
2003年4月 - 2005年3月

農業生物資源研究所, 特別研究員

学歴

1998年4月 - 2003年3月

筑波大学, 農学研究科
- 1998年3月

筑波大学第, 第二学群, 生物資源学類

受賞

2021年9月

Outstanding Paper Award, 日本繁殖生物学会
2015年

東京大学医科学研究所創立記念シンポジウムベストポスター賞

小沢学
2014年8月

優秀ポスター賞, 高遠分子細胞生物学シンポジウム

小沢学
2013年

リバネス研究費アフィメトリクス・ジャパン賞

小沢学
2009年9月

Outstanding Paper Award, 日本繁殖生物学会
2005年3月

奨励賞, 日本畜産学会

小沢学

論文

Ptbp1 deletion does not induce astrocyte-to-neuron conversion.

Thanh Hoang, Dong Won Kim, Haley Appel, Manabu Ozawa, Sika Zheng, Juhyun Kim, Seth Blackshaw

Nature 618(7964) E1-E7 2023年6月
Gene Targeting in Mouse Embryonic Stem Cells via CRISPR/Cas9 Ribonucleoprotein (RNP)-Mediated Genome Editing.

Manabu Ozawa, Chihiro Emori, Masahito Ikawa

Methods in molecular biology (Clifton, N.J.) 2637 87-97 2023年
Efficient simultaneous double DNA knock-in in murine embryonic stem cells by CRISPR/Cas9 ribonucleoprotein-mediated circular plasmid targeting for generating gene-manipulated mice.

Manabu Ozawa, Jumpei Taguchi, Kento Katsuma, Yu Ishikawa-Yamauchi, Mio Kikuchi, Reiko Sakamoto, Yasuhiro Yamada, Masahito Ikawa

Scientific reports 12(1) 21558-21558 2022年12月13日査読有り筆頭著者責任著者
CRISPR/Cas9-Mediated Highly Efficient Gene Targeting in Embryonic Stem Cells for Developing Gene-Manipulated Mouse Models.

Manabu Ozawa, Chihiro Emori, Masahito Ikawa

Journal of visualized experiments : JoVE (186) 2022年8月24日査読有り筆頭著者責任著者
Splice factor polypyrimidine tract-binding protein 1 (Ptbp1) primes endothelial inflammation in atherogenic disturbed flow conditions.

Jessica A Hensel, Sarah-Anne E Nicholas, Amy L Kimble, Arjun S Nagpal, Omar M F Omar, Jordan D Tyburski, Evan R Jellison, Antoine Ménoret, Manabu Ozawa, Annabelle Rodriguez-Oquendo, Anthony T Vella, Patrick A Murphy

Proceedings of the National Academy of Sciences of the United States of America 119(30) e2122227119 2022年7月26日
Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina.

Thanh Hoang, Dong Won Kim, Haley Appel, Nicole A Pannullo, Patrick Leavey, Manabu Ozawa, Sika Zheng, Minzhong Yu, Neal S Peachey, Seth Blackshaw

Cell reports 39(11) 110849-110849 2022年6月14日
Generation of mice for evaluating endogenous p16Ink4a protein expression.

Yui Shimada-Takayama, Takayuki Yasuda, Tomoyo Ukai, Jumpei Taguchi, Manabu Ozawa, Nao Sankoda, Sho Ohta, Yasuhiro Yamada

Biochemical and biophysical research communications 599 43-50 2022年4月9日査読有り
MYCL-mediated reprogramming expands pancreatic insulin-producing cells

Michitada Hirano, Yusei So, Shin Tsunekawa, Mio Kabata, Sho Ohta, Hiroshi Sagara, Nao Sankoda, Jumpei Taguchi, Yosuke Yamada, Tomoyo Ukai, Makoto Kato, Jiro Nakamura, Manabu Ozawa, Takuya Yamamoto, Yasuhiro Yamada

Nature Metabolism 2022年2月10日査読有り
Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages.

Kaiwen Liu, Ryota Sato, Takuma Shibata, Ryosuke Hiranuma, Tatjana Reuter, Ryutaro Fukui, Yun Zhang, Takeshi Ichinohe, Manabu Ozawa, Nobuaki Yoshida, Eicke Latz, Kensuke Miyake

International immunology 33(9) 479-490 2021年8月23日査読有り
DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency.

Jumpei Taguchi, Hirofumi Shibata, Mio Kabata, Masaki Kato, Kei Fukuda, Akito Tanaka, Sho Ohta, Tomoyo Ukai, Kanae Mitsunaga, Yosuke Yamada, So I Nagaoka, Sho Yamazawa, Kotaro Ohnishi, Knut Woltjen, Tetsuo Ushiku, Manabu Ozawa, Mitinori Saitou, Yoichi Shinkai, Takuya Yamamoto, Yasuhiro Yamada

Nature communications 12(1) 5041-5041 2021年8月19日査読有り
Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function.

Tadashi Yamamuro, Shuhei Nakamura, Yu Yamano, Tsutomu Endo, Kyosuke Yanagawa, Ayaka Tokumura, Takafumi Matsumura, Kiyonori Kobayashi, Hideto Mori, Yusuke Enokidani, Gota Yoshida, Hitomi Imoto, Tsuyoshi Kawabata, Maho Hamasaki, Akiko Kuma, Sohei Kuribayashi, Kentaro Takezawa, Yuki Okada, Manabu Ozawa, Shinichiro Fukuhara, Takashi Shinohara, Masahito Ikawa, Tamotsu Yoshimori

PLoS genetics 17(8) e1009688 2021年8月査読有り
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo.

Satotaka Omori, Teh-Wei Wang, Yoshikazu Johmura, Tomomi Kanai, Yasuhiro Nakano, Taketomo Kido, Etsuo A Susaki, Takuya Nakajima, Shigeyuki Shichino, Satoshi Ueha, Manabu Ozawa, Kisho Yokote, Soichiro Kumamoto, Atsuya Nishiyama, Takeharu Sakamoto, Kiyoshi Yamaguchi, Seira Hatakeyama, Eigo Shimizu, Kotoe Katayama, Yasuhiro Yamada, Satoshi Yamazaki, Kanako Iwasaki, Chika Miyoshi, Hiromasa Funato, Masashi Yanagisawa, Hiroo Ueno, Seiya Imoto, Yoichi Furukawa, Nobuaki Yoshida, Kouji Matsushima, Hiroki R Ueda, Atsushi Miyajima, Makoto Nakanishi

Cell metabolism 32(5) 814-828 2020年11月3日査読有り
NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility.

Daiji Kiyozumi, Taichi Noda, Ryo Yamaguchi, Tomohiro Tobita, Takafumi Matsumura, Kentaro Shimada, Mayo Kodani, Takashi Kohda, Yoshitaka Fujihara, Manabu Ozawa, Zhifeng Yu, Gabriella Miklossy, Kurt M Bohren, Masato Horie, Masaru Okabe, Martin M Matzuk, Masahito Ikawa

Science (New York, N.Y.) 368(6495) 1132-1135 2020年6月5日査読有り
RNA-binding protein Ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with Nanos3

Manami SENOO, Hiroshi HOZOJI, Yu ISHIKAWA-YAMAUCHI, Takashi TAKIJIRI, Sho OHTA, Tomoyo UKAI, Mio KABATA, Takuya YAMAMOTO, Yasuhiro YAMADA, Masahito IKAWA, Manabu OZAWA

Journal of Reproduction and Development 66(5) 459-467 2020年査読有り最終著者責任著者
Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas.

Shingo Komura, Kenji Ito, Sho Ohta, Tomoyo Ukai, Mio Kabata, Fumiaki Itakura, Katsunori Semi, Yutaka Matsuda, Kyoichi Hashimoto, Hirofumi Shibata, Masamitsu Sone, Norihide Jo, Kazuya Sekiguchi, Takatoshi Ohno, Haruhiko Akiyama, Katsuji Shimizu, Knut Woltjen, Manabu Ozawa, Junya Toguchida, Takuya Yamamoto, Yasuhiro Yamada

Nature communications 10(1) 3999-3999 2019年9月5日査読有り
PTBP1 contributes to spermatogenesis through regulation of proliferation in spermatogonia.

Senoo M, Takijiri T, Yoshida N, Ozawa M, Ikawa M

The Journal of reproduction and development 65(1) 37-46 2019年2月査読有り責任著者
RNA binding protein Ptbp1 is essential for BCR-mediated antibody production.

Sasanuma H, Ozawa M, Yoshida N

International immunology 31(3) 157-166 2018年11月査読有り
WNT regulation of embryonic development likely involves pathways independent of nuclear CTNNB1

Paula Tribulo, James I. Moss, Manabu Ozawa, Zongliang Jiang, Xiuchun (Cindy) Tian, Peter J. Hansen

REPRODUCTION 153(4) 405-419 2017年4月査読有り
Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex

Xiaochang Zhang, Ming Hui Chen, Xuebing Wu, Andrew Kodani, Jean Fan, Ryan Doan, Manabu Ozawa, Jacqueline Ma, Nobuaki Yoshida, Jeremy F. Reiter, Douglas L. Black, Peter V. Kharchenko, Phillip A. Sharp, Christopher A. Walsh

CELL 166(5) 1147-+ 2016年8月査読有り
Regulation of gene expression in the bovine blastocyst by colony stimulating factor 2

Manabu Ozawa, Miki Sakatani, Kyle B. Dobbs, Jasmine Kannampuzha-Francis, Peter J. Hansen

BMC Research Notes 9(1) 250 2016年4月29日査読有り筆頭著者

もっとみる

MISC

ヒストン脱メチル化酵素Kdm2aは精原細胞の自己複製と分化のバランスを調整する

小沢学, 川上絵里, 徳永暁憲, 坂本怜子, 吉田進昭

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 88回・38回 [4T20L-10(3P0929)] 2015年12月
Developmental changes in thermoprotective actions of insulin-like growth factor-1 on the preimplantation bovine embryo (vol 332, pg 170, 2011)

A. Q. Bonilla, U. Oliveira, M. Ozawa, E. M. Newsom, M. C. Lucy, P. J. Hansen

MOLECULAR AND CELLULAR ENDOCRINOLOGY 413(C) 248-248 2015年9月
Regulation of Pluripotency of Inner Cell Mass and Growth and Differentiation of Trophectoderm of the Bovine Embryo by Colony Stimulating Factor 2 (vol 89, pg 141, 2013)

Kyle B. Dobbs, Firdous A. Khan, Miki Sakatani, James I. Moss, Manabu Ozawa, Alan D. Ealy, Peter J. Hansen

BIOLOGY OF REPRODUCTION 91(5) 2014年11月
Importance of culture conditions during the morula-to-blastocyst period on capacity of inner cell-mass cells of bovine blastocysts for establishment of self-renewing pluripotent cells (vol 78, pg 1243, 2012)

M. Ozawa, M. Sakatani, K. E. Hankowski, N. Terada, K. B. Dobbs, P. J. Hansen

THERIOGENOLOGY 81(7) 1004-1004 2014年4月
A novel method for purification of inner cell mass and trophectoderm cells from blastocysts using magnetic activated cell sorting (vol 95, pg 799, 2011)

Manabu Ozawa

FERTILITY AND STERILITY 101(3) 884-884 2014年3月
ヒストン脱メチル化酵素Kdm2aによる精子形成の制御機序

小沢学, 川上絵里, 徳永暁憲, 坂本怜子, 吉田進昭

The Journal of Reproduction and Development 59(Suppl.) j84-j84 2013年8月
DEVELOPMENTAL CHANGES IN THERMOPROTECTIVE ACTIONS OF INSULIN-LIKE GROWTH FACTOR-1 ON THE PREIMPLANTATION BOVINE EMBRYO

A. Q. S. Bonilla, L. J. Oliveira, M. Ozawa, E. M. Newsom, M. C. Lucy, P. J. Hansen

REPRODUCTION FERTILITY AND DEVELOPMENT 23(1) 165-166 2011年
A NOVEL METHOD FOR PURIFICATION OF INNER CELL MASS AND TROPHECTODERM CELLS FROM BOVINE BLASTOCYSTS USING MAGNETIC ACTIVATED CELL SORTING

M. Ozawa, P. J. Hansen

REPRODUCTION FERTILITY AND DEVELOPMENT 23(1) 174-175 2011年
Actions of Insulin-Like Growth Factor I to Increase Development of Bovine Embryos to the Blastocyst Stage

Aline Quadros Santos Bonilla, Manabu Ozawa, Peter J. Hansen

BIOLOGY OF REPRODUCTION 93-93 2010年
FGF2 Promotes Primitive Endoderm Development in Bovine Blastocysts

Qi-En Yang, Sarah D. Fields, Kun Zhang, Manabu Ozawa, Sally E. Johnson, Alan D. Ealy

BIOLOGY OF REPRODUCTION 90-90 2010年
Expression Profiling of Fibroblast Growth Factor Receptors (FGFRs) and FGF4, and Their Roles During Pre- and Pen-Implantation Embryonic Development in the Bovine.

Manabu Ozawa, Alan D. Ealy

BIOLOGY OF REPRODUCTION 106-106 2010年
Cumulus Cells Enclosed Oocyte Acquires a Capacity to Synthesize Glutathione Through FSH Stimulation via GJCs in Cumulus-Oocyte-Complexes in Pigs

Manabu Ozawa, Takashi Nagai, Tamas Somtai, Michiko Nakai, Naoki Macdoman, Hitoshi Miyazaki, Hiroyuki Kaneko, Junko Noguchi, Kazuhiro Kikuchi

BIOLOGY OF REPRODUCTION 111-111 2009年
Alleviation of maternal hyperthermia-induced early embryonic death by administration of DL-alpha-tocopherol acetate accompanied by a reduction of physiological oxidative stress in mice

M. Ozawa, N. Sakamoto, K. Yokotani-Tomita, A. Morimoto, D. Ijiri, M. Hirabayashi, A. Ushitani, K. Yukio

REPRODUCTION IN DOMESTIC ANIMALS 43 208-208 2008年7月
Polyploidy in porcine embryos produced in vitro

T. Somfai, M. Ozawa, J. Noguchi, H. Kaneko, M. Nakai, N. Maedomari, T. Nagai, K. Kikuchi

REPRODUCTION IN DOMESTIC ANIMALS 43 7-8 2008年7月
Effect of cytoplast volume on fertilization and embryo development in porcine M-II oocytes reconstructed with karyoplasts and cytoplasts obtained by the 'centri-fusion' method

N. Maedomari, K. Kikuchi, M. Fahrudin, N. Nakai, M. Ozawa, T. Somfai, J. Ito, J. Noguchi, H. Kaneko, T. Nagai, N. Kashiwazaki

REPRODUCTION FERTILITY AND DEVELOPMENT 20(1) 102-102 2008年
Development of evenly and unevenly cleaved two-cell porcine embryos

D. N. Q. Thanh, K. Kikuchi, T. Somfai, M. Ozawa, M. Nakai, N. Maedomari, B. X. Nguyen, T. Nagai

REPRODUCTION FERTILITY AND DEVELOPMENT 20(1) 188-189 2008年
Effects of cysteine in IVM media on in vitro maturation under low oxygen tension, in vitro fertilization, and in vitro culture of porcine oocytes

N. V. Linh, D. N. Q. Thanh, M. Ozawa, B. X. Nguyen, K. Kikuchi, T. Nagai

REPRODUCTION FERTILITY AND DEVELOPMENT 20(1) 203-203 2008年
Delayed cleavage of pig embryos after intracytoplasmic sperm injection (ICSI) relates to an ability of blastocyst development

Michiko Nakai, Tamas Somfai, Manabu Ozawa, Naoki Maedomari, Junko Noguchi, Hiroyuki Kaneko, Naomi Kashiwazaki, Kazuhiro Kikuchi

BIOLOGY OF REPRODUCTION 303-304 2008年
Production of live piglets by cryopreservation of in vitro-produced porcine zygotes

T. Somfai, N. Kashiwazaki, M. Ozawa, J. Noguchi, H. Kaneko, M. Nakai, N. Maedomari, T. Nagai, K. Kikuchi

REPRODUCTION FERTILITY AND DEVELOPMENT 20(1) 127-127 2008年
遠心・融合核置換ブタ卵の細胞質量増加による体外受精および胚発生の改善

前泊直樹, 前泊直樹, 菊地和弘, 中井美智子, 小沢学, ソムファイタマス, 伊藤潤哉, 野口純子, 金子浩之, 永井卓, 柏崎直巳

Journal of Reproduction and Development 53(Supplement) 2007年

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小沢学

基本情報

研究キーワード

研究分野

経歴

学歴

受賞

論文

MISC

所属学協会

メニュー

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