論文

査読有り 筆頭著者
2012年10月

Clinical correlates associated with cognitive dysfunction in people with schizophrenia

PSYCHIATRY AND CLINICAL NEUROSCIENCES
  • Tsunehiko Tanaka
  • Masahito Tomotake
  • Yoshinori Ueoka
  • Yasuhiro Kaneda
  • Kyoko Taniguchi
  • Masahito Nakataki
  • Shusuke Numata
  • Shinya Tayoshi
  • Ken Yamauchi
  • Satsuki Sumitani
  • Takashi Ohmori
  • Shu-ichi Ueno
  • Tetsuro Ohmori
  • 全て表示

66
6
開始ページ
491
終了ページ
498
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1440-1819.2012.02390.x
出版者・発行元
WILEY-BLACKWELL

Aims The purpose of the present study was to investigate the correlation between cognitive function and clinical variables in people with schizophrenia. Methods The subjects were 61 stabilized outpatients with schizophrenia (DSM-IV). Their mean age was 40.1 (SD?=?12.2) years. All subjects gave written informed consent to participate in the research. Cognitive function was evaluated using the Brief Assessment of Cognition in Schizophrenia. Clinical symptoms were assessed using the Positive and Negative Syndrome Scale, the Calgary Depression Scale for Schizophrenia, and the Drug-Induced Extrapyramidal Symptoms Scale. Results The Positive and Negative Syndrome Scale Negative syndrome score was significantly correlated with verbal memory score (r?=?-0.37, P?<?0.01), working memory score (r?=?0.38, P?<?0.01), attention and speed of information processing score (r?=?-0.51, P?<?0.01), verbal fluency score (r?=?-0.39, P?<?0.01), and composite score (r?=?-0.54, P?<?0.01). In addition, the Drug-Induced Extrapyramidal Symptoms Scale score was significantly correlated with attention and speed of information processing (r?=?-0.45, P?<?0.01), and composite score (r?=?-0.41, P?<?0. 01). Dose of antipsychotics and anti-Parkinson drugs was not significantly correlated with the Brief Assessment of Cognition in Schizophrenia scores. Conclusions These results indicate that cognitive dysfunction of people with schizophrenia might be associated with negative and drug-induced extrapyramidal symptoms, suggesting that their minimization would be important for improving cognitive dysfunction.

リンク情報
DOI
https://doi.org/10.1111/j.1440-1819.2012.02390.x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23066766
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000310031200004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/j.1440-1819.2012.02390.x
  • ISSN : 1323-1316
  • eISSN : 1440-1819
  • PubMed ID : 23066766
  • Web of Science ID : WOS:000310031200004

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