Moto Fukai

J-GLOBAL         Last updated: Nov 6, 2019 at 15:05
 
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Name
Moto Fukai
Affiliation
Hokkaido University
Section
Graduate School of Medicine

Research Areas

 
 

Published Papers

 
Shimagaki T, Yoshio S, Kawai H, Sakamoto Y, Doi H, Matsuda M, Mori T, Osawa Y, Fukai M, Yoshida T, Ma Y, Akita T, Tanaka J, Taketomi A, Hanayama R, Yoshizumi T, Mori M, Kanto T
Scientific reports   9(1) 15788   Oct 2019   [Refereed]
Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, Hirano J, Zhang H, Chen DV, Ishiga H, Komoda Y, Ono C, Fukuhara T, Yamamoto M, Ikawa M, Satoh T, Akira S, Tanaka T, Moriishi K, Fukai M, Taketomi A, Yoshio S, Kanto T, Suzuki T, Okamoto T, Matsuura Y
Journal of virology   93(6)    Mar 2019   [Refereed]
Ishikawa T, Shimada S, Fukai M, Kimura T, Umemoto K, Shibata K, Fujiyoshi M, Fujiyoshi S, Hayasaka T, Kawamura N, Kobayashi N, Shimamura T, Taketomi A
Surgery today   48(12) 1081-1088   Dec 2018   [Refereed]
Sawai H, Nishida N, Khor SS, Honda M, Sugiyama M, Baba N, Yamada K, Sawada N, Tsugane S, Koike K, Kondo Y, Yatsuhashi H, Nagaoka S, Taketomi A, Fukai M, Kurosaki M, Izumi N, Kang JH, Murata K, Hino K, Nishina S, Matsumoto A, Tanaka E, Sakamoto N, Ogawa K, Yamamoto K, Tamori A, Yokosuka O, Kanda T, Sakaida I, Itoh Y, Eguchi Y, Oeda S, Mochida S, Yuen MF, Seto WK, Poovorawan Y, Posuwan N, Mizokami M, Tokunaga K
Scientific reports   8(1) 7958   May 2018   [Refereed]
Kawamata F, Patch AM, Nones K, Bond C, McKeone D, Pearson SA, Homma S, Liu C, Fennell L, Dumenil T, Hartel G, Kobayasi N, Yokoo H, Fukai M, Nishihara H, Kamiyama T, Burge ME, Karapetis CS, Taketomi A, Leggett B, Waddell N, Whitehall V
Oncotarget   9(3) 3394-3405   Jan 2018   [Refereed]
Shoji H, Yoshio S, Mano Y, Doi H, Sugiyama M, Osawa Y, Kimura K, Arai T, Itokawa N, Atsukawa M, Aoki Y, Fukai M, Taketomi A, Mizokami M, Kanto T
International journal of cancer   141(5) 1011-1017   Sep 2017   [Refereed]
Ohata T, Yokoo H, Kamiyama T, Fukai M, Aiyama T, Hatanaka Y, Hatanaka K, Wakayama K, Orimo T, Kakisaka T, Kobayashi N, Matsuno Y, Taketomi A
Cancer medicine   6(5) 1049-1061   May 2017   [Refereed]
Shimada S, Wakayama K, Fukai M, Shimamura T, Ishikawa T, Fukumori D, Shibata M, Yamashita K, Kimura T, Todo S, Ohsawa I, Taketomi A
Artificial organs   40(12) 1128-1136   Dec 2016   [Refereed]
Baba M, Takahashi M, Yamashiro K, Yokoo H, Fukai M, Sato M, Hosoda M, Kamiyama T, Taketomi A, Yamashita H
Surgery today   46(7) 843-851   Jul 2016   [Refereed]
Shoji H, Yoshio S, Mano Y, Kumagai E, Sugiyama M, Korenaga M, Arai T, Itokawa N, Atsukawa M, Aikata H, Hyogo H, Chayama K, Ohashi T, Ito K, Yoneda M, Nozaki Y, Kawaguchi T, Torimura T, Abe M, Hiasa Y, Fukai M, Kamiyama T, Taketomi A, Mizokami M, Kanto T
Scientific reports   6 28814   Jul 2016   [Refereed]
Ichikawa N, Yamashita K, Funakoshi T, Ichihara S, Fukai M, Ogura M, Kobayashi N, Zaitsu M, Yoshida T, Shibasaki S, Koshizuka Y, Tsunetoshi Y, Sato M, Einama T, Ozaki M, Umezawa K, Suzuki T, Todo S
Inflammation research : official journal of the European Histamine Research Society ... [et al.]   65(3) 245-260   Mar 2016   [Refereed]
Zaitsu M, Yamashita K, Shibasaki S, Tsunetoshi Y, Fukai M, Ogura M, Yoshida T, Igarashi R, Kobayashi N, Umezawa K, Todo S
Transplantation   99(5) 948-956   May 2015   [Refereed]
Shimada S, Fukai M, Wakayama K, Ishikawa T, Kobayashi N, Kimura T, Yamashita K, Kamiyama T, Shimamura T, Taketomi A, Todo S
Surgery today   45(7) 892-903   Jul 2015   [Refereed]
FUJIYOSHI MASATO, KUNO ATSUSHI, GOTO MASANORI, FUKAI MOTO, YOKOO HIDEKI, KAMACHI HIROFUMI, KAMIYAMA TOSHIYA, KORENAGA MASAAKI, MIZOKAMI MASASHI, NARIMATSU HISASHI, TAKETOMI AKINOBU
肝胆膵   70 39-44   Mar 2015
Fujiyoshi M, Kuno A, Gotoh M, Fukai M, Yokoo H, Kamachi H, Kamiyama T, Korenaga M, Mizokami M, Narimatsu H, Taketomi A, Hepatitis Glyco-biomarker Study Group
Journal of gastroenterology   50(11) 1134-1144   Mar 2015   [Refereed]
Kubo K, Ohnishi S, Hosono H, Fukai M, Kameya A, Higashi R, Yamada T, Onishi R, Yamahara K, Takeda H, Sakamoto N
Transplantation direct   1(4) e16   May 2015   [Refereed]
FUKAI MOTO, SHIMAMURA TSUYOSHI, TAKETOMI AKINOBU
Organ Biol   21(2) 159-165   Jul 2014
Donor shortage has been an unresolved problem in clinical transplantation. It is difficult to enlarge donor pool to the expanded criteria donor(ECD)by simple cold storage, due to the severe ischemia and reperfusion injury (IRI). Resuscitation of t...
YAMASHITA KEN'ICHIRO, WATANABE MASAAKI, KOSHIZUKA YASUYUKI, TAKAHASHI TOORU, KURATANI DAISUKE, OGURA MASAOMI, YOSHIDA TADASHI, KYOKU YO, ONO JIN, FUKAI HAJIME, KAMACHI HIROFUMI, SUZUKI TOMOMI, SHIMAMURA TSUYOSHI, TAKETOMI AKINOBU, UMEZAWA KAZUO, TODO SATORU
肝胆膵   68(4) 569-582   Apr 2014
TANIGUCHI MASAHIKO, FUKAI HAJIME, SUZUKI TATSUYA, UCHIDA KOICHIRO, FURUKAWA HIROYUKI
肝胆膵   68(4) 563-568   Apr 2014
Fukai Moto, Shimada Shingo, Wakayama Kenji, Shimamura Tsuyoshi, Yamashita Kenichiro, Todo Satoru, Taketomi Akinobu
Organ Biology   20(2) 176-180   2013
It is no doubt that a new methodology to repair grafts from extended criteria donor(ECD)is necessary in a clinical settings of organ transplantation. The superiority of organ perfusion, to cold storage, is generally accepted in ECD grafts. However...
Wakayama K, Fukai M, Yamashita K, Kimura T, Hirokata G, Shibasaki S, Fukumori D, Haga S, Sugawara M, Suzuki T, Taniguchi M, Shimamura T, Furukawa H, Ozaki M, Kamiyama T, Todo S
Transplant international : official journal of the European Society for Organ Transplantation   25(6) 696-706   Jun 2012   [Refereed]
Funakoshi T, Yamashita K, Ichikawa N, Fukai M, Suzuki T, Goto R, Oura T, Kobayashi N, Katsurada T, Ichihara S, Ozaki M, Umezawa K, Todo S
Journal of Crohn's & colitis   6(2) 215-225   Mar 2012   [Refereed]
Fukai Moto, Taketomi Akinobu, Todo Satoru
Organ Biology   19(1) 70-75   2012
Although organ cooling is beneficial for any kind of grafts, mainly by metabolic arrest, hypoxia and hypothermia concomitantly cause harmful reactions, such as ATP depletion, mitochondrial dysfunction, cytosolic Ca2+ overload, intracellular acidos...
深井 原, 嶋村 剛
医学のあゆみ   237(5) 583-591   Apr 2011   [Invited]
Fukai Moto, Todo Satoru
Organ Biology   18(1) 92-98   2011   [Invited]
Heavy water, deuterium oxide(D2O), is a stable isotope compound of H2O, causing stabilization of actin and tubulin. D2O inhibits cytosolic calcium overload via plasma membrane channel and ER. D2O stimulates ATP production by augmenting glucose upt...
Ozaki Michitaka, Haga Sanae, Morita Naoki, Fukai Moto, Todo Satoru, Ozawa Takeaki, Ohmiya Yoshihiro
Organ Biology   18(1) 134-140   2011
In order to develop an effective organ/cell preservation solution and to monitor graft function continuously and non-invasively, an innovative imaging technology to visualize cell/organ function is required. Recently, we developed molecular probes...
Suzuki T, Yamashita K, Jomen W, Ueki S, Aoyagi T, Fukai M, Furukawa H, Umezawa K, Ozaki M, Todo S
The Journal of surgical research   149(1) 69-75   Sep 2008   [Refereed]
Watanabe E, Mochizuki N, Ajima H, Ohno K, Shiino M, Umezawa K, Fukai M, Ozaki M, Furukawa H, Todo S, Kishino S
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences   871(1) 32-36   Aug 2008   [Refereed]
FUKAI Moto, HAGA Sanae, OZAKI Michitaka
臨床化学   37(2) 131-140   Apr 2008
Zhang HQ, Haga S, Fukai M, Oikawa Y, Inoue H, Ogawa W, Kano A, Maruyama A, Fu XY, Todo S, Enosawa S, Ozaki M
Hepatology research : the official journal of the Japan Society of Hepatology   38(4) 374-384   Apr 2008   [Refereed]
Haga S, Terui K, Fukai M, Oikawa Y, Irani K, Furukawa H, Todo S, Ozaki M
Journal of hepatology   48(3) 422-432   Mar 2008   [Refereed]
Magata S, Taniguchi M, Suzuki T, Shimamura T, Fukai M, Furukawa H, Fujita M, Todo S
The Journal of surgical research   139(1) 7-14   May 2007   [Refereed]
Huda KA, Guo L, Haga S, Murata H, Ogino T, Fukai M, Yagi T, Iwagaki H, Tanaka N, Ozaki M
Transplant international : official journal of the European Society for Organ Transplantation   19(5) 415-423   May 2006   [Refereed]
Fukai M, Hayashi T, Yokota R, Shimamura T, Suzuki T, Taniguchi M, Matsushita M, Furukawa H, Todo S
Free radical biology & medicine   38(10) 1372-1381   May 2005   [Refereed]
Suzuki T, Jin MB, Shimamura T, Yamashita K, Taniguchi M, Nomura M, Yokota R, Fukai M, Magata S, Horiuchi H, Fujita M, Nagashima K, Furukawa H, Todo S
Transplant international : official journal of the European Society for Organ Transplantation   17(10) 574-584   Nov 2004   [Refereed]
MISHIMA Osamu, NAKAMURA Takahisa, FUKAI Moto, IGARASHI Motomu, KONDO Hiroshi
日本臨床外科学会雑誌 = The journal of the Japan Surgical Association   64(7) 1613-1617   Jul 2003
Mishima Osamu, Fukai Moto, Yokota Ryoiti
The journal of the Japanese Association for Chest Surgery   17(5) 570-573   Jul 2003
Here we report a case of intralobar pulmonary sequestration resected by thoracoscopic surgery. A 38-year-old woman was admitted to our hospital with an abnormal shadow in the right lower lung field on chest X-ray. Chest CT and angiography were don...
Mishima Osamu, Fukai Moto, Yokota Ryoichi
The journal of the Japanese Association for Chest Surgery   17(4) 495-499   May 2003
We report two cases of postoperative bronchial fistula successfully treated by endoscopic closure with coils and fibrin glue. Patient 1 was a 65-year-old man with diabetes and old myocardial infarction. He underwent right lower lobectomy for lung ...
Mishima Osamu, Fukai Moto, Yokota Ryoichi
The journal of the Japanese Association for Chest Surgery   17(4) 505-510   May 2003
A 50-year-old man was admitted to our hospital with abdominal pain due to urinary stone. High serum levels of Ca, intact PTH. And high-sensitivity PTH suggested hyper-parathyroidism. ^<99m>Tc-MIBI scintigram showed abnormal uptake in the upper med...
Takeda K, Jin MB, Fujita M, Fukai M, Sakurai T, Nakayama M, Taniguchi M, Suzuki T, Shimamura T, Furukawa H, Todo S
Surgery   133(2) 197-206   Feb 2003   [Refereed]
嶋村 剛, 石川 博人, 深井 原, 古川 博之, 藤堂 省
Nihon Naika Gakkai Kaishi   90(1) 21-28   Jan 2001
肝移植は末期肝疾患に対する根本的治療として,世界中で年間約8,000例に施行され, 5生率は成人72%,小児80%に達している.世界的に臓器不足が問題となっており,社会的・医学的両面から様々な解決策が試みられている.本邦での脳死肝移植の問題点として,臓器提供意思表示カードの低配布率,提供施設の限定などが上げられる.また,原疾患に対する再発予防手段の進歩からレシピエント選択基準の見直しは必須である.

Conference Activities & Talks

 
柴田賢吾, 橋本咲月, 早坂孝宏, 深井原, 加藤紘一, 中薮拓哉, 島田慎吾, 小林希, 梅本浩平, 大谷晋太郎, 三野和宏, 嶋村剛, 木村太一, 武冨紹信
日本外科学会定期学術集会(Web)   Apr 2019   
大腸癌診療におけるprecision medicine ゲノム解析を利用した大腸癌原発巣およびその肝転移巣に対するprecision medicine
川俣 太, 本間 重紀, Patch Ann-Marie, 沢田 尭史, 市川 伸樹, 吉田 雅, 柴崎 晋, Waddell Nicola, Whitehall Vicki, Leggett Barbara, 深井 原, 川村 秀樹, 神山 俊哉, 武冨 紹信
日本外科学会定期学術集会抄録集   Apr 2019   
深井原, 柴田賢吾, 島田慎吾, 石川隆壽, 若山顕治, 藤好直, 小林希, 加藤紘一, 早坂孝宏, 三野和宏, 川村典生, 嶋村剛, 武冨紹信
日本外科学会定期学術集会(Web)   Apr 2019   
川俣太, 本間重紀, PATCH Ann‐marie, 沢田尭史, 市川伸樹, 吉田雅, 柴崎晋, WADDELL Nicola, WHITEHALL Vicki, LEGGETT Barbara, 深井原, 川村秀樹, 神山俊哉, 武冨紹信
日本外科学会定期学術集会(Web)   2019   
坂本譲, 由雄祥代, 河合裕成, 島垣智成, 森泰三, 松田道隆, 大澤陽介, 深井原, 神山俊哉, 考藤達哉, 武冨紹信
日本外科学会定期学術集会(Web)   Apr 2019   

Research Grants & Projects

 
脂肪肝グラフトの脂肪滴を有効利用する画期的な保護性タンパク質機能の賦活法の探索
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: Apr 2019 - Mar 2022    Investigator(s): Kenji WAKAYAMA
イメージング質量分析を用いた癌微小環境一細胞脂質プロファイルの解明
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: Apr 2019 - Mar 2022    Investigator(s): Takahiro HAYASAKA
DGKα/ζを標的とした消化器がんに対する次世代免疫療法の開発研究
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: Apr 2019 - Mar 2022    Investigator(s): Akinobu TAKETOMI
新生肝細胞創出による機能不全に陥った肝臓を蘇らせるための基礎的研究
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: Apr 2018 - Mar 2021    Investigator(s): Toshihiro MITAKA
14-3-3とNrf2の制御による革新的な心停止腎グラフトの灌流修復法の開発
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: Apr 2017 - Mar 2020    Investigator(s): Moto FUKAI
脂肪肝グラフトのミトコンドリア機能と抗酸化能を増強する画期的な肝体外灌流法の開発
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: Apr 2016 - Mar 2020    Investigator(s): Tsuyoshi SHIMAMURA
遺伝子導入を用いずに移植片のシャペロン発現を体外で調節する方法の開発
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: Apr 2015 - Mar 2017    Investigator(s): Kazuhiro MINO
シャペロン分子により生存シグナルを増強させる画期的な肝グラフト修復法の開発
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: Apr 2014 - Mar 2017    Investigator(s): Tsuyoshi SHIMAMURA
心停止下ドナーによる肝移植のための新規保存液を用いたグラフト灌流保存法の開発
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: Apr 2013 - Mar 2017    Investigator(s): Masahiko TANIGUCU
臓器不足解消を目指した画期的脂肪肝グラフト修復法の開発
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: Apr 2013 - Mar 2016    Investigator(s): Tsuyoshi SHIMAMURA
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: 2011 - 2012    Investigator(s): Furukawa HIROYUKI
We confirmed that the superiority of the novel solution over UW solution for the use of simple cold preservation in rat liver and heart, due to the inhibition of cytosolic Ca2+ overload and cytoskeletal breakdown, and stimulation of aerobic respir...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 2010 - 2012    Investigator(s): Satoru TODO
We explored the necessary condition of heavy water containing buffer for the use of simple cold preservation. The novel solution appeared to show excellent cytoprotection in various cells, and rat liver and heart, due to the inhibition of cytosoli...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: 2006 - 2007    Investigator(s): Moto FUKAI
新規保存液の1)-3)に対する細胞保護効果が明らかになった。1)肝細胞株AML12の低温(4℃)曝露による傷害、2)低温・低酸素による傷害、3)低温・低酸素/復温・再酸素化よる傷害。上記1〜3)でアポトーシスが時間依存的に進行したが、新規保存液によって著明に軽減された。また、4)同様の著明な細胞保護効果が小腸上皮細胞、気管上皮細胞でも認められた。膵頭細胞では他の細胞と比較すると保護効果がやや低かった。5)低温下での肝細胞株のグルコースの取り込みを有意に促進した。6)肝細胞株、小腸細胞株に過...