Yamamori Tomoko

Profile Information

Degree: 博士 (理学)(同志社大学)

Other name(s) (e.g. nickname): Morita Tomoko
J-GLOBAL ID: 201401093964049595
researchmap Member ID: B000239208

External link

Research Areas

Life sciences / Tumor biology /

Papers

CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade

Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Ryo Kamata, Gaku Yamamoto, Tatsunori Minamide, Chiaki Mashima, Miyuki Yoshiya, Yuta Sakae, Toyohiro Yamauchi …

Nature Communications, 14(1), Nov 18, 2023 Peer-reviewedLead author
Abstract 2048: Property analysis of chromosomal instability-adapted cells using multi-omics approaches

Tomoko Yamamori Morita, Hiroshi Haeno, Hideki Makinoshima, Ayako Suzuki, Susumu S. Kobayashi, Akihiro Ohashi

Cancer Research, 81(13_Supplement) 2048-2048, Jul 1, 2021
Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells.

Yumi Fujimoto, Tomoko Yamamori Morita, Akihiro Ohashi, Hiroshi Haeno, Yumi Hakozaki, Masanori Fujii, Yukie Kashima, Susumu S Kobayashi, Toru Mukohara

Scientific reports, 10(1) 21762-21762, Dec 10, 2020 Peer-reviewedLead author
Multi-omics approaches to clarify adaptive mechanisms of cancer cells to antiproliferative effects by chromosomal instability

T. Y. Morita, H. Haeno, H. Makinoshima, A. Suzuki, S. S. Kobayashi, A. Ohashi

European Journal of Cancer, 138 S31, Oct, 2020
ZAK inhibitor PLX4720 promotes extrusion of transformed cells via cell competition

Takeshi Maruyama, Ayana Sasaki, Sayuri Iijima, Shiyu Ayukawa, Nobuhito Goda, Keisuke Tazuru, Norikazu Hashimoto, Takashi Hayashi, Kei Kozawa, Nanami Sato …

iScience, 101327-101327, Jun, 2020 Peer-reviewed
Autophagy-dependent regulation of tumor metastasis by myeloid cells

Masahisa Jinushi, Tomoko Morita, Zhihang Xu, Ichiro Kinoshita, Hirotoshi Dosaka-Akita, Hideo Yagita, Yutaka Kawakami

PLOS ONE, 12(7) e0179357, Jul, 2017 Peer-reviewed
Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

Shunsuke Kon, Kojiro Ishibashi, Hiroto Katoh, Sho Kitamoto, Takanobu Shirai, Shinya Tanaka, Mihoko Kajita, Susumu Ishikawa, Hajime Yamauchi, Yuta Yako …

NATURE CELL BIOLOGY, 19(5) 530-+, May, 2017 Peer-reviewed
Plectin is a novel regulator for apical extrusion of RasV12-transformed cells

Ailijiang Kadeer, Takeshi Maruyama, Mihoko Kajita, Tomoko Morita, Ayana Sasaki, Atsuko Ohoka, Susumu Ishikawa, Masaya Ikegawa, Takashi Shimada, Yasuyuki Fujita

SCIENTIFIC REPORTS, 7 44328, Mar, 2017 Peer-reviewed
Novel chemoimmunotherapeutic strategy for hepatocellular carcinoma based on a genome-wide association study

Kaku Goto, Dorcas A. Annan, Tomoko Morita, Wenwen Li, Ryosuke Muroyama, Yasuo Matsubara, Sayaka Ito, Ryo Nakagawa, Yasushi Tanoue, Masahisa Jinushi …

SCIENTIFIC REPORTS, 6 38407, Dec, 2016 Peer-reviewed
The cell competition-based high-throughput screening identifies small compounds that promote the elimination of RasV12-transformed cells from epithelia

Hajime Yamauchi, Takanori Matsumaru, Tomoko Morita, Susumu Ishikawa, Katsumi Maenaka, Ichigaku Takigawa, Kentaro Semba, Shunsuke Kon, Yasuyuki Fujita

SCIENTIFIC REPORTS, 5 15336, Oct, 2015 Peer-reviewed
The Coordinated Actions of TIM-3 on Cancer and Myeloid Cells in the Regulation of Tumorigenicity and Clinical Prognosis in Clear Cell Renal Cell Carcinomas

Yoshihiro Komohara, Tomoko Morita, Dorcas A. Annan, Hasita Horlad, Koji Ohnishi, Sohsuke Yamada, Toshiyuki Nakayama, Shohei Kitada, Shinya Suzu, Ichiro Kinoshita …

CANCER IMMUNOLOGY RESEARCH, 3(9) 999-1007, Sep, 2015 Peer-reviewed
The casein kinase 2-Nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression

Yoshiki Tsuchiya, Hiroaki Taniguchi, Yoshiyuki Ito, Tomoko Morit, M. Rezaul Karim, Norihito Ohtake, Kousuke Fukagai, Takao Ito, Shota Okamuro, Shun-Ichiro Iemura …

Molecular and Cellular Biology, 33(17) 3461-3472, 2013 Peer-reviewed
Dual Regulation of the Transcriptional Activity of Nrf1 by beta-TrCP- and Hrd1-Dependent Degradation Mechanisms

Yoshiki Tsuchiya, Tomoko Morita, Mehee Kim, Shun-ichiro Iemura, Tohru Natsume, Masayuki Yamamoto, Akira Kobayashi

MOLECULAR AND CELLULAR BIOLOGY, 31(22) 4500-4512, Nov, 2011 Peer-reviewedLead author
Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction

Akira Kobayashi, Takako Tsukide, Tomohiro Miyasaka, Tomoko Morita, Tatsuya Mizoroki, Yoshiro Saito, Yasuo Ihara, Akihiko Takashima, Noriko Noguchi, Akiyoshi Fukamizu …

GENES TO CELLS, 16(6) 692-703, Jun, 2011 Peer-reviewed

Presentations

BRCA2非翻訳領域上に存在する新規生殖細胞系列突然変異のメカニズム解析

山盛(森田)智子, 箱崎優美, 藤本祐未, 齋藤仁志, 鹿島幸恵, 鎌田諒, 眞島千晶, 清野透, 堀居拓郎, 牛尼美年子, 平岡弓枝, 榮雄大, 仲尾岳大, 原野謙一, 古川孝広, 藤井誠志, 桑田健, 吉田輝彦, 向原徹, 大橋紹宏

第46回日本分子生物学会年会, Dec 8, 2023
新規クラスター化合物Ag5の細胞死誘導メカニズムの解明

鎌田諒, 山内豊大, 齋藤仁志, 榮雄大, 山盛智子, Fernando Dominguez、Ross, Breckenridge、Martin Treder, 大橋紹宏

第46回日本分子生物学会年会, Dec 6, 2023
CENP-E阻害剤は染色体不均等分配を惹起し小核形成とcGAS-STING経路を活性化する

鎌田諒, 齋藤仁志, 箱崎優美, 鹿島幸恵, 山本岳, 眞島千晶, 山盛智子, PinyiLu, 大橋紹宏

第46回日本分子生物学会年会, Dec 6, 2023
CTNNB1・PIK3CA共存遺伝子変異を持つ子宮体癌におけるWnt/β-Cateninシグナルの抗腫瘍効果

仲尾岳大, 齋藤仁志, 鎌田諒, 山本岳, 山内豊大, 山盛(森田) 智子, 上井美里, 眞島千晶, 向原徹, 大橋紹宏

第82回日本癌学会学術総会, Sep, 2023
ROSをターゲットとした新規クラスター化合物Ag5の細胞死メカニズム

鎌田諒, 山内豊大, 齋藤仁志, 榮雄大, 山盛智子, Fernando Dominguez, Ross Breckenridge, Martin Treder, 大橋紹宏

第82回日本癌学会学術総会, Sep, 2023
Abstract 301: CENP-E inhibitors activate cGAS-STING pathway by inducing chromosome misalignment and micronucleation after mitotic slippage

Ryo Kamata, Hitoshi Saito, Yumi Hakozaki, Yukie Kashima, Tomoko Yamamori Morita, Pinyi Lu, Akihiro Ohashi

Cancer Research, Apr 4, 2023, American Association for Cancer Research (AACR)
Abstract 5687: CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors

Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Kosuke Tanaka, Tatsunori Minamide, Chiaki Mashima, Yumi Hakozaki, Shun-ichiro Kageyama, Akito Nakamura, Eric Lightcap, Huifeng Niu, Karuppiah Kannan, Akihiro Ohashi

Cancer Research, Jun 15, 2022, American Association for Cancer Research (AACR)
Abstract 5635: Combined MEK and mitophagy inhibition promotes mtDNA-mediated innate immunity in KRAS-mutant cancer

Kosuke Tanaka, Tomoko Yamamori Morita, Yumi Hakozaki, Miyuki Yoshiya, Chiaki Mashima, Jie Liu, Shun-ichiro Kageyama, Akihiro Ohashi, Susumu Kobayashi

Cancer Research, Jun 15, 2022, American Association for Cancer Research (AACR)
RIG-I pathway regulates radiotherapy-induced immune response in cancer cells

Junyan Du, Riu Yamashita, Yumi Hakozaki, Ohashi Akihiro, Tomoko Morita, Kosuke Tanaka, Katsuya Tsuchihara, Shunichiro Kageyama

Dec, 2021
CDC7阻害剤はDNA複製ストレスを介した炎症反応を惹起し、免疫チェックポイント阻害剤の感受性を高める

山盛智子, Yu Jie, 鹿島幸恵, 田中広祐, 南出竜典, 箱崎優美, 影山俊一郎, Akito Nakamura, Lightcap Eric, Niu Huifeng, Kannan Karuppiah, 大橋紹宏

第44回日本分子生物学会年会, Dec, 2021
Abstract P029: CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors

Tomoko Y. Morita, Jie Yu, Yukie Kashima, Kosuke Tanaka, Yumi Hakozaki, Shun-ichiro Kageyama, Akito Nakamura, Eric Lightcap, Huifeng Niu, Karuppiah Kannan, Akihiro Ohashi

Molecular Cancer Therapeutics, Dec 1, 2021, American Association for Cancer Research (AACR)
Abstract 1030: CENP-E inhibition generates micronucleus formation activating the cGAS-STING pathway in cancer cells

Yumi Hakozaki, Yukie Kashima, Tomoko Y. Morita, Kosuke Tanaka, Susumu S. Kobayashi, Akihiro Ohashi

Cancer Research, Jul 1, 2021, American Association for Cancer Research (AACR)
Abstract 2048: Property analysis of chromosomal instability-adapted cells using multi-omics approaches

Tomoko Yamamori Morita, Hiroshi Haeno, Hideki Makinoshima, Ayako Suzuki, Susumu S. Kobayashi, Akihiro Ohashi

Cancer Research, Jul 1, 2021, American Association for Cancer Research (AACR)
Adaptation to chromosomal instability-mediated antiproliferative stresses causes metabolic modification in cancer cells

Tomoko M. Yamamori, Akihiro Ohashi, Hiroshi Haeno, Hideki Makinoshima, Ayako Suzuki, Susumu Kobayashi

Oct, 2020
Multi-omics approaches to clarify adaptive mechanisms of cancer cells to antiproliferative effects by chromosomal instability

T.Y. Morita, H. Haeno, H. Makinoshima, A. Suzuki, S.S. Kobayashi, A. Ohashi

European Journal of Cancer, Oct, 2020, Elsevier BV

Professional Memberships

Sep, 2021 - Present

日本分子生物学会
Dec, 2020 - Present

American Association for Cancer Research
Apr, 2020 - Present

Japanese Cancer Association

Research Projects

染色体不安定性を有する細胞の細胞死回避メカニズムの解明

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2021 - Mar, 2024

山盛智子
SA-T cell

Japan Health Research Promotion Bureau, Apr, 2022 - Mar, 2024
Elucidation of the mechanism for determining the winner of cell competition among cancer cells with genetic diversity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2019 - Mar, 2021

Yamamori Morita Tomoko
The development of novel cancer therapeutic/diagnostic drugs targeting cell competition.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Morita Tomoko

Profile Information

Research Areas

Papers

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Professional Memberships

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