論文

査読有り 筆頭著者 国際誌
2019年4月15日

The juvenility-associated long noncoding RNA Gm14230 maintains cellular juvenescence

Journal of Cell Science
  • Ayami Tano
  • ,
  • Yosuke Kadota
  • ,
  • Takao Morimune
  • ,
  • Faidruz Azura Jam
  • ,
  • Haruka Yukiue
  • ,
  • Jean-Pierre Bellier
  • ,
  • Tatsuyuki Sokoda
  • ,
  • Yoshihiro Maruo
  • ,
  • Ikuo Tooyama
  • ,
  • Masaki Mori

132
8
開始ページ
jcs227801
終了ページ
jcs227801
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1242/jcs.227801
出版者・発行元
The Company of Biologists

Juvenile animals possess distinct properties that are missing in adults. These properties include capabilities for higher growth, faster wound healing, plasticity and regeneration. However, the molecular mechanisms underlying these juvenile physiological properties are not fully understood. To obtain insight into the distinctiveness of juveniles from adults at the molecular level, we assessed long noncoding RNAs (lncRNAs) that are highly expressed selectively in juvenile cells. The noncoding elements of the transcriptome were investigated in hepatocytes and cardiomyocytes isolated from juvenile and adult mice. Here, we identified 62 juvenility-associated lncRNAs (JAlncs), which are selectively expressed in both hepatocytes and cardiomyocytes from juvenile mice. Among these common (shared) JAlncs, Gm14230 is evolutionarily conserved and is essential for cellular juvenescence. Loss of Gm14230 impairs cell growth and causes cellular senescence. Gm14230 safeguards cellular juvenescence through recruiting the histone methyltransferase Ezh2 to Tgif2, thereby repressing the functional role of Tgif2 in cellular senescence. Thus, we identify Gm14230 as a juvenility-selective lncRNA required to maintain cellular juvenescence.

リンク情報
DOI
https://doi.org/10.1242/jcs.227801
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30872457
URL
https://syndication.highwire.org/content/doi/10.1242/jcs.227801
ID情報
  • DOI : 10.1242/jcs.227801
  • ISSN : 0021-9533
  • eISSN : 1477-9137
  • PubMed ID : 30872457

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