Jan 17, 2022
Effluent N‐terminal expressed in renal cell carcinoma/mesothelin predicts increased peritoneal permeability in patients undergoing peritoneal dialysis
Therapeutic Apheresis and Dialysis
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- Volume
- 26
- Number
- 5
- First page
- 1014
- Last page
- 1022
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1111/1744-9987.13786
- Publisher
- Wiley
INTRODUCTION: We investigated whether N-terminal and C-terminal products of expressed in renal cell carcinoma/mesothelin (N-ERC and C-ERC) in peritoneal effluent can predict peritoneal permeability in patients undergoing peritoneal dialysis (PD). METHODS: Thirty-seven peritoneal effluent samples were obtained from 26 PD patients. High transport status was determined by the peritoneal equilibration test as a dialysate/plasma ratio of creatinine (D/P Cr) ≥ 0.81. Effluent cancer antigen 125 (CA125) was used as a reference. RESULTS: Effluent N-ERC concentration was better correlated with D/P Cr than effluent C-ERC or CA125 concentration. In multivariate analyses, effluent N-ERC and C-ERC, but not CA125, were significant predictors of high transport status after adjusting for age, PD duration, and residual renal Kt/V. ROC analysis showed that effluent N-ERC was the best predictor of high transport status among those three biomarkers. CONCLUSION: Effluent N-ERC predicts increased peritoneal permeability in patients undergoing PD.
- Link information
- ID information
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- DOI : 10.1111/1744-9987.13786
- ISSN : 1744-9979
- eISSN : 1744-9987
- Pubmed ID : 34962348