2005年8月
Farnesylation of retinal transducin underlies its translocation during light adaptation
NEURON
- 巻
- 47
- 号
- 4
- 開始ページ
- 529
- 終了ページ
- 539
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neuron.2005.07.025
- 出版者・発行元
- CELL PRESS
G proteins are posttranslationally modified by isoprenylation: either farnesylation or geranylgeranylation. The gamma subunit of retinal transducin (T alpha/T beta gamma) is selectively farnesylated, and the farnesylation is required for light signaling mediated by transducin in rod cells. However, whether and how this selective isoprenylation regulates cellular functions remain poorly understood. Here we report that knockin mice expressing geranylgeranylated T gamma showed normal rod responses to dim flashes under dark-adapted conditions but exhibited impaired properties in light adaptation. Of note, geranylgeranylation of T gamma suppressed light-induced transition of T beta gamma from membrane to cytosol, and also attenuated its light-dependent translocation from the outer segment to the inner region, an event contributing to retinal light adaptation. These results indicate that, while the farnesylation of transducin is interchangeable with the geranylgeranylation in terms of the light signaling, the selective farnesylation is important for visual sensitivity regulation by providing sufficient but not excessive membrane anchoring of T beta gamma.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.neuron.2005.07.025
- CiNii Articles
- http://ci.nii.ac.jp/naid/30010680819
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/16102536
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000231411100010&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1016/j.neuron.2005.07.025
- ISSN : 0896-6273
- CiNii Articles ID : 30010680819
- PubMed ID : 16102536
- Web of Science ID : WOS:000231411100010