Mouri Yasuhiro

Profile Information

Affiliation: 徳島大学

J-GLOBAL ID: 201801015411828617
researchmap Member ID: B000303035

Research Areas

Life sciences / Immunology /

Papers

Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma.

Shengjian Jin, Takaaki Tsunematsu, Taigo Horiguchi, Yasuhiro Mouri, Wenhua Shao, Keiko Miyoshi, Hiroko Hagita, Motoharu Sarubo, Natsumi Fujiwara, Guangying Qi …

Cancer medicine, Nov 20, 2023
歯周病原菌由来細胞外小胞を介した肺炎発症メカニズムの解明

吉田佳世, 吉田賀弥, 瀬山真莉子, 芽形真奈, 藤原奈津美, 水澤典子, 毛利安宏, 工藤保誠, 尾崎和美

日本歯周病学会会誌, 65(春季特別) 137-137, Apr, 2023
Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma.

Shao Wenhua, Takaaki Tsunematsu, Masaaki Umeda, Hiroaki Tawara, Natsumi Fujiwara, Yasuhiro Mouri, Rieko Arakaki, Naozumi Ishimaru, Yasusei Kudo

Cancer medicine, 12(7) 8510-8525, Jan 23, 2023
miR-155-5p can be involved in acquisition of osseointegration on titanium surface

Yoshiko Yamamura, Keiko Miyoshi, Yasuhiro Mouri, Yasusei Kudo, Youji Miyamoto

In Vitro Cellular & Developmental Biology - Animal, 58(8) 693-701, Sep 2, 2022
The role of partial-EMT in the progression of head and neck squamous cell carcinoma.

Satoru Kisoda, Yasuhiro Mouri, Naoya Kitamura, Tetsuya Yamamoto, Keiko Miyoshi, Yasusei Kudo

Journal of oral biosciences, 64(2) 176-182, Jun, 2022
Conversion from epithelial to partial-EMT phenotype by Fusobacterium nucleatum infection promotes invasion of oral cancer cells

Wenhua Shao, Natsumi Fujiwara, Yasuhiro Mouri, Satoru Kisoda, Kayo Yoshida, Kaya Yoshida, Hiromichi Yumoto, Kazumi Ozaki, Naozumi Ishimaru, Yasusei Kudo

Scientific Reports, 11(1), Dec, 2021
The Soluble Factor from Oral Cancer Cell Lines Inhibits Interferon-γ Production by OK-432 via the CD40/CD40 Ligand Pathway.

Go Ohe, Yasusei Kudo, Kumiko Kamada, Yasuhiro Mouri, Natsumi Takamaru, Keiko Kudoh, Naito Kurio, Youji Miyamoto

Cancers, 13(13), Jun 30, 2021
Prognostic value of partial EMT-related genes in head and neck squamous cell carcinoma by a bioinformatic analysis.

Satoru Kisoda, Wenhua Shao, Natsumi Fujiwara, Yasuhiro Mouri, Takaaki Tsunematsu, Shengjian Jin, Rieko Arakaki, Naozumi Ishimaru, Yasusei Kudo

Oral diseases, Apr 11, 2020 Peer-reviewed
Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).

Hitoshi Nishijima, Tatsuya Kajimoto, Yoshiki Matsuoka, Yasuhiro Mouri, Junko Morimoto, Minoru Matsumoto, Hiroshi Kawano, Yasuhiko Nishioka, Hisanori Uehara, Keisuke Izumi …

Journal of autoimmunity, 86 75-92, Jan, 2018 Peer-reviewed
Mode of Tolerance Induction and Requirement for Aire Are Governed by the Cell Types That Express Self-Antigen and Those That Present Antigen.

Yasuhiro Mouri, Yoshihiro Ueda, Tomoyoshi Yamano, Minoru Matsumoto, Koichi Tsuneyama, Tatsuo Kinashi, Mitsuru Matsumoto

Journal of immunology (Baltimore, Md. : 1950), 199(12) 3959-3971, Dec 15, 2017 Peer-reviewed
Aire Expression Is Inherent to Most Medullary Thymic Epithelial Cells during Their Differentiation Program.

Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Fumiko Hirota, Ryoko Morita, Yasuhiro Mouri, Yasuhiko Nishioka, Mitsuru Matsumoto

Journal of immunology (Baltimore, Md. : 1950), 195(11) 5149-58, Dec 1, 2015 Peer-reviewed
Ectopic Aire Expression in the Thymic Cortex Reveals Inherent Properties of Aire as a Tolerogenic Factor within the Medulla.

Hitoshi Nishijima, Satsuki Kitano, Hitoshi Miyachi, Junko Morimoto, Hiroshi Kawano, Fumiko Hirota, Ryoko Morita, Yasuhiro Mouri, Kiyoshi Masuda, Issei Imoto …

Journal of immunology (Baltimore, Md. : 1950), 195(10) 4641-9, Nov 15, 2015 Peer-reviewed
NF-κB-inducing kinase in thymic stroma establishes central tolerance by orchestrating cross-talk with not only thymocytes but also dendritic cells.

Yasuhiro Mouri, Hitoshi Nishijima, Hiroshi Kawano, Fumiko Hirota, Nobuo Sakaguchi, Junko Morimoto, Mitsuru Matsumoto

Journal of immunology (Baltimore, Md. : 1950), 193(9) 4356-67, Nov 1, 2014 Peer-reviewed
Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program.

Yumiko Nishikawa, Hitoshi Nishijima, Minoru Matsumoto, Junko Morimoto, Fumiko Hirota, Satoru Takahashi, Hervé Luche, Hans Joerg Fehling, Yasuhiro Mouri, Mitsuru Matsumoto

Journal of immunology (Baltimore, Md. : 1950), 192(6) 2585-92, Mar 15, 2014 Peer-reviewed
Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling.

Sumiko Yoshida, Ken-Ichi Aihara, Yasumasa Ikeda, Yuka Sumitomo-Ueda, Ryoko Uemoto, Kazue Ishikawa, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Yasuhiro Mouri …

Circulation, 128(1) 60-71, Jul 2, 2013 Peer-reviewed
AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化

西嶋仁, 毛利安宏, 西川裕美子, 松本満

生化学, 85(7) 600-600, Jul, 2013
Which model better fits the role of aire in the establishment of self-tolerance: the transcription model or the maturation model?

Mitsuru Matsumoto, Yumiko Nishikawa, Hitoshi Nishijima, Junko Morimoto, Minoru Matsumoto, Yasuhiro Mouri

Frontiers in immunology, 4 210-210, 2013 Peer-reviewed
先端医学講座 Aireと自己免疫疾患

松本満, 西嶋仁, 西川裕美子, 毛利安宏

アレルギーの臨床, 32(9) 848-852, Aug, 2012
Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.

Yasuhiro Mouri, Masashi Yano, Miho Shinzawa, Yusuke Shimo, Fumiko Hirota, Yumiko Nishikawa, Takuro Nii, Hiroshi Kiyonari, Takaya Abe, Hisanori Uehara …

Journal of immunology (Baltimore, Md. : 1950), 186(9) 5047-57, May 1, 2011 Peer-reviewed
Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation.

Yumiko Nishikawa, Fumiko Hirota, Masashi Yano, Hiroyuki Kitajima, Jun-ichi Miyazaki, Hiroshi Kawamoto, Yasuhiro Mouri, Mitsuru Matsumoto

The Journal of experimental medicine, 207(5) 963-71, May 10, 2010 Peer-reviewed

Misc.

Mechanisms underlying the establishment of T-cell tolerance in the thymus

60(1) 72-77, Jul, 2013
Temporal fate-mapping study reveals essential roles of Aire in the maturation program of Aire-expressing cell lineage

Mitsuru Matsumoto, Yumiko Nishikawa, Yasuhiro Mouri, Hitoshi Nishijima

JOURNAL OF IMMUNOLOGY, 190, May, 2013
Role of lymphotoxin for thymic organogenesis

58(2) 234-238, Aug, 2012
Role of AIRE in the differentiation program of thymic epithelial cells in the medulla

Clinical immunology & allergology, 56(1) 90-96, Jul, 2011
ROLES OF NIK IN THYMIC EPITHELIAL CELLS FOR THE ESTABLISHMENT OF CENTRAL TOLERANCE

Yasuhiro Mouri, Masashi Yano, Mitsuru Matsumoto

ADVANCES IN TNF FAMILY RESEARCH, 691 772-773, 2011
Thymic organogenesis controlled by NF-kappaB activating factors

Masashi Ya, Yasuhiro Mouri, Mitsuru Matsumoto

CLINICAL IMMUNOLOGY, 123 S123-S123, 2007

Research Projects

歯周病が惹起する全身炎症性疾患の機序解明と酸化ストレス制御による予防法確立

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2023 - Mar, 2026

高石和美, 工藤保誠, 川人伸次, 湯本浩通, 毛利安宏, 木下浩之
RNA修飾による糖脂質分解酵素活性制御機構の解明とゴーシェ病克服への挑戦

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2026

三好圭子, 萩田浩子, 堀口大吾, 毛利安宏
Investigation of novel oral cancer-specific molecular targets based on genetic diversity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2026
Investigation of the pathophysiology of oral cancer caused by Fusobacterium nucleatum infection

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
The identification of genes involved in the maintenance and regeneration of salivary gland stem / progenitor cells and application to new xerostomia treatment

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
口腔がんにおける免疫環境構築機構の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

毛利安宏, 工藤保誠
Investigation of novel molecular targets for oral cancer stem cells and establishment of novel oral cancer treatment strategy

Grants-in-Aid for Scientific Research, Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)), Japan Society for the Promotion of Science, Oct, 2021 - Mar, 2025
Elucidation of the pathogenesis of autoimmune disease through the functional study of AIRE

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

MATSUMOTO Mitsuru
Analysis of thymic antigen presenting cells regulated by Aire in the negative selection

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

MOURI Yasuhiro
Studies aiming the establishing self-tolerance for the cure of autoimmune disease

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

MATSUMOTO Mitsuru, NISHIJIMA Hitoshi, MOURI Yasuhiro
Analysis of negative selection regulated by medullary thymic epithelial cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

MOURI Yasuhiro
Approaches to the pathogenesis of psoriasis, an intractable human skin disorder

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2010 - 2012

MOURI Yasuhiro
Transgenic mouse approaches to the pathogenesis of hereditary type of human autoimmune disease

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2009 - 2011

MATSUMOTO Mitsuru, NISHIKAWA Yumiko, MOURI Yasuhiro

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