阪口政清 (Masakiyo Sakaguchi) - マイポータル

基本情報

所属: 岡山大学学術研究院医歯薬学域教授

学位: 博士(医学）(2001年3月岡山大学)

J-GLOBAL ID: 200901055163308042
researchmap会員ID: 5000094923

外部リンク: https://www.okayama-u.ac.jp/user/cellbiol/

研究キーワード

研究分野

経歴

2001年4月 - 2004年3月

日本学術振興会特別研究員（PD）
2004年4月 - 2005年3月

岡山大学大学院医歯学総合研究科, 細胞生物学, 助手
2005年4月 - 2007年3月

岡山大学大学院医歯薬学総合研究科, 細胞生物学, 助手
2007年4月 - 2008年4月

岡山大学大学院医歯薬学総合研究科, 細胞生物学, 助教
2008年5月 - 2013年12月

岡山大学大学院医歯薬学総合研究科, 細胞生物学, 准教授
2014年1月 - 2018年6月

岡山大学大学院医歯薬学総合研究科, 細胞生物学, 独立准教授
2018年7月 - 2021年3月

岡山大学大学院医歯薬学総合研究科, 細胞生物学, 教授
2021年4月 - 現在

岡山大学学術研究院医歯薬学域, 細胞生物学, 教授

委員歴

2024年4月 - 現在

日本組織培養学会, 評議員
2020年1月 - 現在

日本癌学会, 評議員
2023年8月 - 2023年9月

日本組織培養学会第95回大会, 大会長
2017年7月 - 2017年7月

日本組織培養学会第90回大会, プログラム運営委員
2004年

日本組織培養学会, 大会運営補助

受賞

2025年3月

The Springer Nature Editor of Distinction Award, In Vitro Cellular & Developmental Biology - Animal (Springer Nature)
2022年4月

長瀬研究振興賞, 公益財団法人長瀬科学技術振興財団
2021年3月

Acta Medica Okayama Best Reviewer Award
2017年6月

医学賞（結城賞）, 岡山大学
2017年5月

優秀研究者賞, ウエスコ財団
2014年5月

医歯薬学分野学術奨励賞, 公益財団法人山陽放送学術文化財団
2010年1月

若手トップリサーチャー研究奨励賞, 岡山大学
2003年7月

ITO-EN, Ltd. Scholar-in-Training Award, American Association for Cancer Research (AACR)
2001年6月

医学賞（結城賞）, 岡山大学
2000年6月

Student Award, American Society for In Vitro Biology (SIVB)

主要な論文

222

An S100A8/A9 Neutralizing Antibody Potently Ameliorates Contact Hypersensitivity and Atopic Dermatitis Symptoms.

Yuma Gohara, Rie Kinoshita, Nahoko Tomonobu, Fan Jiang, Yukiko Matsunaga, Yuki Hashimoto, Tomoko Honjo, Ken-Ichi Yamamoto, Hitoshi Murata, Toshiki Ochi …

The Journal of investigative dermatology 145(8) 1930-1945 2025年8月査読有り最終著者責任著者
Enhanced design of pCMViR-TSC plasmid vector for sustainably high cargo gene expression in mammalian cells.

Masakiyo Sakaguchi, Rie Kinoshita, Nahoko Tomonobu, Yoshihiko Sakaguchi, Junichiro Futami, Akira Yamauchi, Hitoshi Murata, Ken-Ichi Yamamoto, Tetta Takahashi, Yuma Gohara …

In vitro cellular & developmental biology. Animal 60(10) 1215-1227 2024年12月査読有り筆頭著者責任著者
Dissection of the signal transduction machinery responsible for the lysyl oxidase-like 4-mediated increase in invasive motility in triple-negative breast cancer cells: mechanistic insight into the integrin-β1-NF-κB-MMP9 axis.

Fan Jiang, Youyi Chen, Nahoko Tomonobu, Rie Kinoshita, Ni Luh Gede Yoni Komalasari, Carlos Ichiro Kasano-Camones, Kazumi Ninomiya, Hitoshi Murata, Ken-Ichi Yamamoto, Yuma Gohara …

Frontiers in oncology 14 1371307-1371307 2024年5月28日査読有り最終著者責任著者
Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface.

Tetta Takahashi, Nahoko Tomonobu, Rie Kinoshita, Ken-Ichi Yamamoto, Hitoshi Murata, Ni Luh Gede Yoni Komalasari, Youyi Chen, Fan Jiang, Yuma Gohara, Toshiki Ochi …

Frontiers in oncology 14 1371342-1371342 2024年3月26日査読有り最終著者責任著者
Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells.

Yuma Gohara, Nahoko Tomonobu, Rie Kinoshita, Junichiro Futami, Léna Audebert, Youyi Chen, Ni Luh Gede Yoni Komalasari, Fan Jiang, Chikako Yoshizawa, Hitoshi Murata …

Journal of molecular medicine (Berlin, Germany) 101(4) 431-447 2023年4月査読有り最終著者責任著者
LOXL1 and LOXL4 are novel target genes of the Zn2+-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells.

Daisuke Hirabayashi, Ken-Ichi Yamamoto, Akihiro Maruyama, Nahoko Tomonobu, Rie Kinoshita, Youyi Chen, Ni Luh Gede Yoni Komalasari, Hitoshi Murata, Yuma Gohara, Fan Jiang …

Frontiers in oncology 13 1142886-1142886 2023年2月23日査読有り最終著者責任著者
Toll-like receptor 4 promotes bladder cancer progression upon S100A8/A9 binding, which requires TIRAP-mediated TPL2 activation.

Acosta Gonzalez Herik Rodrigo, Nahoko Tomonobu, Haruka Yoneda, Rie Kinoshita, Yosuke Mitsui, Takuya Sadahira, Shin-Ichi Terawaki, Yuma Gohara, Ni Luh Gede Yoni Komalasari, Fan Jiang …

Biochemical and biophysical research communications 634 83-91 2022年12月17日査読有り最終著者責任著者
Histidine-Rich Glycoprotein Suppresses the S100A8/A9-Mediated Organotropic Metastasis of Melanoma Cells.

Nahoko Tomonobu, Rie Kinoshita, Hidenori Wake, Yusuke Inoue, I Made Winarsa Ruma, Ken Suzawa, Yuma Gohara, Ni Luh Gede Yoni Komalasari, Fan Jiang, Hitoshi Murata …

International journal of molecular sciences 23(18) 10300-10300 2022年9月7日査読有り最終著者責任著者
The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis

Kota Araki, Rie Kinoshita, Nahoko Tomonobu, Yuma Gohara, Shuta Tomida, Yuta Takahashi, Satoru Senoo, Akihiko Taniguchi, Junko Itano, Ken-ichi Yamamoto …

Journal of Molecular Medicine 99(1) 131-145 2020年11月9日査読有り最終著者責任著者
Neuroplastinβ-mediated upregulation of solute carrier family 22 member 18 antisense (SLC22A18AS) plays a crucial role in the epithelial-mesenchymal transition, leading to lung cancer cells' enhanced motility

Karolina Bajkowska, I. Wayan Sumardika, Nahoko Tomonobu, Youyi Chen, Ken-ichi Yamamoto, Rie Kinoshita, Hitoshi Murata, Ni Luh Gede Yoni Komalasari, Fan Jiang, Akira Yamauchi …

Biochemistry and Biophysics Reports 22 100768-100768 2020年7月査読有り最終著者責任著者
Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level

Nahoko Tomonobu, Ni Luh Gede Yoni Komalasari, I Wayan Sumardika, Fan Jiang, Youyi Chen, Ken-ichi Yamamoto, Rie Kinoshita, Hitoshi Murata, Yusuke Inoue, Masakiyo Sakaguchi

Chemico-Biological Interactions 324 109085-109085 2020年6月査読有り最終著者責任著者
exMCAM-Fc, an S100A8/A9-mediated-metastasis blocker, efficiently reduced the number of circulating tumor cells that appeared in the blood flow

Nahoko Tomonobu, Rie Kinoshita, Masakiyo Sakaguchi

Molecular Biology Reports 47(6) 4879-4883 2020年5月7日査読有り最終著者責任著者
S100 Soil Sensor Receptors and Molecular Targeting Therapy Against Them in Cancer Metastasis

Nahoko Tomonobu, Rie Kinoshita, Masakiyo Sakaguchi

Translational Oncology 13(4) 100753-100753 2020年4月査読有り最終著者責任著者
Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts

Yosuke Mitsui, Nahoko Tomonobu, Masami Watanabe, Rie Kinoshita, I Wayan Sumardika, Chen Youyi, Hitoshi Murata, Ken-ichi Yamamoto, Takuya Sadahira, Acosta Gonzalez Herik Rodrigo …

Oncology Research 27(8) 945-956 2019年8月8日査読有り最終著者責任著者
Convenient methodology for extraction and subsequent selective propagation of mouse melanocytes in culture from adult mouse skin tissue

Nahoko Tomonobu, Rie Kinoshita, I. Wayan Sumardika, Youyi Chen, Yusuke Inoue, Akira Yamauchi, Ken-ichi Yamamoto, Hitoshi Murata, Masakiyo Sakaguchi

Biochemistry and Biophysics Reports 18 100619-100619 2019年7月査読有り最終著者責任著者
Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness

Youyi Chen, I Wayan Sumardika, Nahoko Tomonobu, Rie Kinoshita, Yusuke Inoue, Hidekazu Iioka, Yosuke Mitsui, Ken Saito, I Made Winarsa Ruma, Hiroki Sato …

Neoplasia 21(7) 627-640 2019年7月査読有り最終著者責任著者
Extracellular S100A11 Plays a Critical Role in Spread of the Fibroblast Population in Pancreatic Cancers

Hitoshi Takamatsu, Ken-ichi Yamamoto, Nahoko Tomonobu, Hitoshi Murata, Yusuke Inoue, Akira Yamauchi, I Wayan Sumardika, Youyi Chen, Rie Kinoshita, Masahiro Yamamura …

Oncology Research 27(6) 713-727 2019年6月21日査読有り最終著者責任著者
Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion

Youyi Chen, I Wayan Sumardika, Nahoko Tomonobu, I Made Winarsa Ruma, Rie Kinoshita, Eisaku Kondo, Yusuke Inoue, Hiroki Sato, Akira Yamauchi, Hitoshi Murata …

Cancer Letters 452 178-190 2019年6月査読有り最終著者責任著者
Neuroplastin‐β mediates S100A8/A9‐induced lung cancer disseminative progression

I Wayan Sumardika, Youyi Chen, Nahoko Tomonobu, Rie Kinoshita, I Made Winarsa Ruma, Hiroki Sato, Eisaku Kondo, Yusuke Inoue, Akira Yamauchi, Hitoshi Murata …

Molecular Carcinogenesis 58(6) 980-995 2019年2月27日査読有り最終著者責任著者
Newly developed anti‐S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis

Rie Kinoshita, Hiroki Sato, Akira Yamauchi, Yuta Takahashi, Yusuke Inoue, I Wayan Sumardika, Youyi Chen, Nahoko Tomonobu, Kota Araki, Kazuhiko Shien …

International Journal of Cancer 145(2) 569-575 2018年12月14日査読有り最終著者責任著者
exSSSRs (extracellular S100 soil sensor receptors)‐Fc fusion proteins work as prominent decoys to S100A8/A9‐induced lung tropic cancer metastasis

Rie Kinoshita, Hiroki Sato, Akira Yamauchi, Yuta Takahashi, Yusuke Inoue, I. Wayan Sumardika, Youyi Chen, Nahoko Tomonobu, Kota Araki, Kazuhiko Shien …

International Journal of Cancer 144(12) 3138-3145 2018年12月4日査読有り最終著者責任著者
Embigin Promotes Prostate Cancer Progression by S100A4-Dependent and-Independent Mechanisms

I Made Winarsa Ruma, Rie Kinoshita, Nahoko Tomonobu, Yusuke Inoue, Eisaku Kondo, Akira Yamauchi, Hiroki Sato, I Wayan Sumardika, Youyi Chen, Ken-Ichi Yamamoto …

Cancers 10(7) 2018年7月23日査読有り最終著者責任著者
β-1,3-Galactosyl- O-Glycosyl-Glycoprotein-1,6-N-Acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility

I Wayan Sumardika, Chen Youyi, Eisaku Kondo, Yusuke Inoue, I Made Winarsa Ruma, Hitoshi Murata, Rie Kinoshita, Ken-Ichi Yamamoto, Shuta Tomida, Kazuhiko Shien …

Oncology Research 26(3) 431-444 2018年4月10日査読有り最終著者責任著者
Identification of a novel component leading to anti-tumor activity besides the major ingredient cordycepin in Cordyceps militaris extract

Takeharu Wada, I. Wayan Sumardika, Shingo Saito, I. Made Winarsa Ruma, Eisaku Kondo, Masami Shibukawa, Masakiyo Sakaguchi

Journal of Chromatography B 1061 209-219 2017年9月査読有り最終著者責任著者
Expression of tumor suppressor REIC/Dkk-3 by a newly improved adenovirus vector with insertion of a hTERT promoter at the 3′-side of the transgene

Endy Widya Putranto, Rie Kinoshita, Masami Watanabe, Takuya Sadahira, Hitoshi Murata, Ken-Ichi Yamamoto, Junichiro Futami, Ken Kataoka, Yusuke Inoue, I. Made Winarsa Ruma …

Oncology Letters 14(1) 1041-1048 2017年5月17日査読有り最終著者責任著者
Robust cancer-specific gene expression by a novel cassette with hTERT and CMV promoter elements

Masakiyo Sakaguchi, Takuya Sadahira, Hideo Ueki, Rie Kinoshita, Hitoshi Murata, Ken-Ichi Yamamoto, Junichiro Futami, Yasutomo Nasu, Kazuhiko Ochiai, Hiromi Kumon …

Oncology Reports 38(2) 1108-1114 2017年2月査読有り筆頭著者
S100-SPECT uncovers cellular and molecular events of pre-metastatic niche formation and following organ-specific cancer metastasis

Masakiyo Sakaguchi

Theranostics 7(10) 2649-2651 2017年査読有り招待有り筆頭著者最終著者責任著者
Identification of an S100A8 Receptor Neuroplastin-β and its Heterodimer Formation with EMMPRIN

Masakiyo Sakaguchi, Mami Yamamoto, Masashi Miyai, Tatsuo Maeda, Junichiro Hiruma, Hitoshi Murata, Rie Kinoshita, I Made Winarsa Ruma, Endy Widya Putranto, Yusuke Inoue …

Journal of Investigative Dermatology 136(11) 2240-2250 2016年11月査読有り筆頭著者責任著者
MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-κB and ROS formation upon ligand binding

I. Made, Winarsa Ruma, ndy Widya Putranto, Eisaku Kondo, Hitoshi Murata, Masami Watanabe, Peng Huang, Rie Kinoshita, Junichiro Futami, Yusuke Inoue …

Clinical and Experimental Metastasis 33(6) 609-27 2016年8月査読有り最終著者責任著者
DNAX-activating Protein 10 (DAP10) Membrane Adaptor Associates with Receptor for Advanced Glycation End Products (RAGE) and Modulates the RAGE-triggered Signaling Pathway in Human Keratinocytes

Masakiyo Sakaguchi, Hitoshi Murata, Yumi Aoyama, Toshihiko Hibino, Endy Widya Putranto, I. Made Winarsa Ruma, Yusuke Inoue, Yoshihiko Sakaguchi, Ken-ichi Yamamoto, Rie Kinoshita …

Journal of Biological Chemistry 289(34) 23389-23402 2014年8月査読有り筆頭著者責任著者
Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells

I. Made Winarsa Ruma, Endy Widya Putranto, Eisaku Kondo, Risayo Watanabe, Ken Saito, Yusuke Inoue, Ken-Ichi Yamamoto, Susumu Nakata, Masaji Kaihata, Hitoshi Murata …

International Journal of Oncology 45(1) 209-218 2014年7月査読有り最終著者責任著者
Dramatic Increase in Expression of a Transgene by Insertion of Promoters Downstream of the Cargo Gene

Masakiyo Sakaguchi, Masami Watanabe, Rie Kinoshita, Haruki Kaku, Hideo Ueki, Junichiro Futami, Hitoshi Murata, Yusuke Inoue, Shun-Ai Li, Peng Huang …

Molecular Biotechnology 56(7) 621-630 2014年2月14日査読有り筆頭著者責任著者
Inhibition of RAGE signaling through the intracellular delivery of inhibitor peptides by PEI cationization

Endy Widya Putranto, Hitoshi Murata, Ken-Ichi Yamamoto, Ken Kataoka, Hidenori Yamada, Jun-Ichiro Futami, Masakiyo Sakaguchi, Nam-Ho Huh

International Journal of Molecular Medicine 32(4) 938-944 2013年10月査読有り責任著者
Coxsackie and adenovirus receptor is a critical regulator for the survival and growth of oral squamous carcinoma cells

K Saito, M Sakaguchi, H Iioka, M Matsui, H Nakanishi, N H Huh, E Kondo

Oncogene 33(10) 1274-1286 2013年3月18日査読有り筆頭著者
S100A11, a dual growth regulator of epidermal keratinocytes

Masakiyo Sakaguchi, Nam-ho Huh

Amino Acids 41(4) 797-807 2011年10月査読有り筆頭著者
A Novel Tumor Suppressor, REIC/Dkk-3 Gene Identified by Our In Vitro Transformation Model of Normal Human Fibroblasts Works as a Potent Therapeutic Anti-tumor Agent

Masakiyo Sakaguchi, Nam-ho Huh, Masayoshi Namba

Advances in Experimental Medicine and Biology 209-215 2011年8月11日査読有り筆頭著者
TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding

Masakiyo Sakaguchi, Hitoshi Murata, Ken-ichi Yamamoto, Tomoyuki Ono, Yoshihiko Sakaguchi, Akira Motoyama, Toshihiko Hibino, Ken Kataoka, Nam-ho Huh

PLoS ONE 6(8) e23132-e23132 2011年8月1日査読有り筆頭著者
Overexpression of REIC/Dkk-3 in Normal Fibroblasts Suppresses Tumor Growth via Induction of Interleukin-7

Masakiyo Sakaguchi, Ken Kataoka, Fernando Abarzua, Ryuta Tanimoto, Masami Watanabe, Hitoshi Murata, Swe Swe Than, Kaoru Kurose, Yuji Kashiwakura, Kazuhiko Ochiai …

Journal of Biological Chemistry 284(21) 14236-14244 2009年5月査読有り筆頭著者
S100A11, an Dual Mediator for Growth Regulation of Human Keratinocytes

Masakiyo Sakaguchi, Hiroyuki Sonegawa, Hitoshi Murata, Midori Kitazoe, Jun-ichiro Futami, Ken Kataoka, Hidenori Yamada, Nam-ho Huh

Molecular Biology of the Cell 19(1) 78-85 2008年1月査読有り筆頭著者
Truncation of Annexin A1 Is a Regulatory Lever for Linking Epidermal Growth Factor Signaling with Cytosolic Phospholipase A2 in Normal and Malignant Squamous Epithelial Cells

Masakiyo Sakaguchi, Hitoshi Murata, Hiroyuki Sonegawa, Yoshihiko Sakaguchi, Jun-ichiro Futami, Midori Kitazoe, Hidenori Yamada, Nam-ho Huh

Journal of Biological Chemistry 282(49) 35679-35686 2007年12月査読有り筆頭著者
Bifurcated converging pathways for high Ca ² +- and TGFβ-induced inhibition of growth of normal human keratinocytes

Masakiyo Sakaguchi, Hiroyuki Sonegawa, Takamasa Nukui, Yoshihiko Sakaguchi, Masahiro Miyazaki, Masayoshi Namba, Nam-ho Huh

Proceedings of the National Academy of Sciences 102(39) 13921-13926 2005年9月19日査読有り筆頭著者
Targeted disruption of transcriptional regulatory function of p53 by a novel efficient method for introducing a decoy oligonucleotide into nuclei

Masakiyo Sakaguchi, Takamasa Nukui, Hiroyuki Sonegawa, Hitoshi Murata, Junichiro Futami, Hidenori Yamada, Nam-ho Huh

Nucleic Acids Research 33(9) e88-e88 2005年5月16日査読有り筆頭著者
PKCα mediates TGFβ-induced growth inhibition of human keratinocytes via phosphorylation of S100C/A11

Masakiyo Sakaguchi, Masahiro Miyazaki, Hiroyuki Sonegawa, Mariko Kashiwagi, Motoi Ohba, Toshio Kuroki, Masayoshi Namba, Nam-ho Huh

The Journal of Cell Biology 164(7) 979-984 2004年3月29日査読有り筆頭著者
S100C/A11 is a key mediator of Ca2+-induced growth inhibition of human epidermal keratinocytes

Masakiyo Sakaguchi, Masahiro Miyazaki, Mikiro Takaishi, Yoshihiko Sakaguchi, Eiichi Makino, Noriyuki Kataoka, Hidenori Yamada, Masayoshi Namba, Nam-ho Huh

The Journal of Cell Biology 163(4) 825-835 2003年11月17日査読有り筆頭著者
Involvement of Arachidonic Acid in Nonimmunologic Production of Superoxide in Mast Cells

Masakiyo Sakaguchi, Nobuyuki Fukuishi, Kazuyo Teramoto, Masahiro Miyazaki, Nam-ho Huh, Masayoshi Namba, Masaaki Akagi

International Archives of Allergy and Immunology 130(4) 288-299 2003年5月9日査読有り筆頭著者責任著者
Up-regulation of S100C in normal human fibroblasts in the process of aging in vitro

Masakiyo Sakaguchi, Masahiro Miyazaki, Tadashi Kondo, Masayoshi Namba

Experimental Gerontology 36(8) 1317-1325 2001年8月査読有り筆頭著者
Identification of a phosphoprotein that is downregulated in immortalized human fibroblasts

Masakiyo Sakaguchi, Masahiro Miyazaki, Tadashi Kondo, Toshiya Tsuji, Hirosuke Kouchi, Masayoshi Namba

Electrophoresis 22(1) 155-160 2001年1月査読有り筆頭著者
Loss of Nuclear Localization of the S100C Protein in Immortalized Human Fibroblasts

M. Sakaguchi, H. Yamada, T. Tsuji, Y. Inoue, M. Miyazaki, T. Tanaka, M. Namba

Radiation Research 155(1) 208-214 2001年1月査読有り筆頭著者
Relationship between Contact Inhibition and Intranuclear S100c of Normal Human Fibroblasts

Masakiyo Sakaguchi, Masahiro Miyazaki, Yusuke Inoue, Toshiya Tsuji, Hirosuke Kouchi, Toshio Tanaka, Hidenori Yamada, Masayoshi Namba

The Journal of Cell Biology 149(6) 1193-1206 2000年6月12日査読有り筆頭著者
Transferrin synthesized in cultured human fibroblasts is associated with tubulins and has iron binding capacity

Masakiyo Sakaguchi, Tadashi Kondo, Hong Pu, Masayoshi Namba

Cell Structure and Function 24(1) 5-9 1999年査読有り筆頭著者

もっとみる

主要なMISC

191

Two arms of TGFβ signaling

Masakiyo Sakaguchi

Journal of Cell Biology 164(7) 951-951 2004年3月29日査読有り筆頭著者
A contact-inhibition signal

Masakiyo Sakaguchi

Journal of Cell Biology 149(6) 1-1 2000年6月12日査読有り筆頭著者