論文

査読有り 国際誌
2020年2月21日

PLOD2 Is Essential to Functional Activation of Integrin β1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas.

iScience
  • Yushi Ueki
  • ,
  • Ken Saito
  • ,
  • Hidekazu Iioka
  • ,
  • Izumi Sakamoto
  • ,
  • Yasuhiro Kanda
  • ,
  • Masakiyo Sakaguchi
  • ,
  • Arata Horii
  • ,
  • Eisaku Kondo

23
2
開始ページ
100850
終了ページ
100850
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.isci.2020.100850

Identifying the specific functional regulator of integrin family molecules in cancer cells is critical because they are directly involved in tumor invasion and metastasis. Here we report high expression of PLOD2 in oropharyngeal squamous cell carcinomas (SCCs) and its critical role as a stabilizer of integrin β1, enabling integrin β1 to initiate tumor invasion/metastasis. Integrin β1 stabilized by PLOD2-mediated hydroxylation was recruited to the plasma membrane, its functional site, and accelerated tumor cell motility, leading to tumor metastasis in vivo, whereas loss of PLOD2 expression abrogated it. In accordance with molecular analysis, examination of oropharyngeal SCC tissues from patients corroborated PLOD2 expression associated with integrin β1 at the invasive front of tumor nests. PLOD2 is thus implicated as the key regulator of integrin β1 that prominently regulates tumor invasion and metastasis, and it provides important clues engendering novel therapeutics for these intractable cancers.

リンク情報
DOI
https://doi.org/10.1016/j.isci.2020.100850
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32058962
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997870
ID情報
  • DOI : 10.1016/j.isci.2020.100850
  • PubMed ID : 32058962
  • PubMed Central 記事ID : PMC6997870

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