2000年9月
Treatment of surgically induced acute liver failure with transplantation of highly differentiated immortalized human hepatocytes
CELL TRANSPLANTATION
- 巻
- 9
- 号
- 5
- 開始ページ
- 733
- 終了ページ
- 735
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- COGNIZANT COMMUNICATION CORP
Primary human hepatocytes are an ideal source of hepatic function in bioartficial liver (BAL), but the shortage of human livers available for hepatocyte isolation limits this modality. To resolve this issue, primary human fetal hepatocytes were immortalized using simian virus 40 large T antigen. One of the immortal cell lines, OUMS-29, showed highly differentiated liver functions. Intrasplenic transplantation of OUMS-29 cells protected 90% hepatectomized rats from hyperammonemia and significantly prolonged their survival. Essentially unlimited availability of OUMS-29 cells supports their clinical use for BAL treatment.
- リンク情報
- ID情報
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- ISSN : 0963-6897
- Web of Science ID : WOS:000165702700024