論文

査読有り
2017年9月

Blockade of intracellular Zn2+ signaling in the basolateral amygdala affects object recognition memory via attenuation of dentate gyrus LTP

NEUROCHEMISTRY INTERNATIONAL
  • Yuki Fujise
  • ,
  • Mitsuyasu Kubota
  • ,
  • Miki Suzuki
  • ,
  • Haruna Tarnano
  • ,
  • Atsushi Takeda

108
開始ページ
1
終了ページ
6
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neuint.2017.01.014
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Hippocampus-dependent memory is modulated by the amygdala. However, it is unknown whether intracellular Zn2+ signaling in the amygdala is involved in hippocampus-dependent memory. On the basis of the evidence that intracellular Zn2+ signaling in dentate granule cells (DGC) is necessary for object recognition memory via LTP at medial perforant pathway (PP)-DGC synapses, the present study examined whether intracellular Zn2+ signaling in the amygdala influences object recognition memory via modulation of LTP at medial PP-DGC synapses. When ZnAF-2DA (100 mu M, 2 mu l) was injected into the basolateral amygdala (BLA), intracellular ZnAF-2 locally chelated intracellular Zn2+ in the amygdala. Recognition memory was affected when training of object recognition test was performed 20 min after ZnAF-2DA injection into the BLA. Twenty minutes after injection of ZnAF-2DA into the BLA, LTP induction at medial PP-DGC synapses was attenuated, while LTP induction at PP-BLA synapses was potentiated and LTP induction at BLA-DGC synapses was attenuated. These results suggest that intracellular Zn2+ signaling in the BLA is involved in BLA-associated LTP and modulates LTP at medial PP-DGC synapses, followed by modulation of object recognition memory. (C) 2017 Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.1016/j.neuint.2017.01.014
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28131899
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000406569700001&DestApp=WOS_CPL

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