論文

査読有り
2015年8月

Excess influx of Zn2+ into dentate granule cells affects object recognition memory via attenuated LTP

NEUROCHEMISTRY INTERNATIONAL
  • Miki Suzuki
  • ,
  • Yuki Fujise
  • ,
  • Yuka Tsuchiya
  • ,
  • Haruna Tamano
  • ,
  • Atsushi Takeda

87
開始ページ
60
終了ページ
65
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neuint.2015.05.006
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

The influx of extracellular Zn2+ into dentate granule cells is nonessential for dentate gyrus long-term potentiation (LTP) and the physiological significance of extracellular Zn2+ dynamics is unknown in the dentate gyrus. Excess increase in extracellular Zn2+ in the hippocampal CM, which is induced with excitation of zincergic neurons, induces memory deficit via excess influx of Zn2+ into CA1 pyramidal cells. In the present study, it was examined whether extracellular Zn2+ induces object recognition memory deficit via excess influx of Zn2+ into dentate granule cells. KC1 (100 mM, 2 mu l) was locally injected into the dentate gyrus. The increase in intracellular Zn2+ in dentate granule cells induced with high K+ was blocked by co-injection of CaEDTA and CNQX, an extracellular Zn2+ chelator and an AMPA receptor antagonist, respectively, suggesting that high K+ increases the influx of Zn2+ into dentate granule cells via AMPA receptor activation. Dentate gyrus LTP induction was attenuated 1 h after KC1 injection into the dentate gyrus and also attenuated when KC1 was injected 5 min after the induction. Memory deficit was induced when training of object recognition test was performed 1 h after KC1 injection into the dentate gyrus and also induced when KC1 was injected 5 min after the training. High K+-induced impairments of LTP and memory were rescued by co-injection of CaEDTA. These results indicate that excess influx of Zn2+ into dentate granule cells via AMPA receptor activation affects object recognition memory via attenuated LTP induction. Even in the dentate gyrus where is scarcely innervated by zincergic neurons, it is likely that extracellular Zn2+ homeostasis is strictly regulated for cognition. (C) 2015 Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 26

リンク情報
DOI
https://doi.org/10.1016/j.neuint.2015.05.006
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26044210
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000359330400006&DestApp=WOS_CPL

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