Masakuni Serizawa - My portal

Profile Information

Affiliation: Shizuoka Cancer Center,Research Institute

Degree: 博士（工学）(信州大学)

Researcher number: 00569915
J-GLOBAL ID: 201801021323593642
researchmap Member ID: B000332243

External link: https://www.scchr.jp/researchinstitute/dept_intro/new_medicine_lab.html

Research Interests

Research Areas

Professional Memberships

Papers

Genetic alterations of driver genes as independent prognostic factors for disease-free survival in patients with resected non-small cell lung cancer.

Ono A, Isaka M, Serizawa M, Omae K, Kojima H, Nakashima K, Omori S, Wakuda K, Kenmotsu H, Naito T …

Lung cancer (Amsterdam, Netherlands), 128 152-157, Feb, 2019 Peer-reviewed
Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations

Keiichi Hatakeyama, Keiichi Ohshima, Takeshi Nagashima, Shumpei Ohnami, Sumiko Ohnami, Masakuni Serizawa, Yuji Shimoda, Koji Maruyama, Yasuto Akiyama, Kenichi Urakami …

Scientific Reports, 8(1) 8700, Dec 1, 2018 Peer-reviewed
PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue.

Tomoya Yokota, Masakuni Serizawa, Ayumu Hosokawa, Kimihide Kusafuka, Keita Mori, Toshiro Sugiyama, Yasuhiro Tsubosa, Yasuhiro Koh

BMC cancer, 18(1) 826-826, Aug 16, 2018 Peer-reviewed
Tumor mutational burden analysis of 2,000 Japanese cancer genomes using whole exome and targeted gene panel sequencing

Keiichi Hatakeyama, Takeshi Nagashima, Kenichi Urakami, Keiichi Ohshima, Masakuni Serizawa, Sumiko Ohnami, Yuji Shimoda, Shumpei Ohnami, Koji Maruyama, Akane Naruoka …

Biomedical Research (Japan), 39(3) 159-167, 2018 Peer-reviewed
Comparison of Clinically Relevant Mutation Profiles Between Preoperative Biopsy and Corresponding Surgically Resected Specimens in Japanese Patients With Non-Small-cell Lung Cancer by Amplicon-based Massively Parallel Sequencing

Mitsuhiro Isaka, Masakuni Serizawa, Hirotsugu Kenmotsu, Yasuhiro Koh, Shoji Takahashi, Tomohiro Maniwa, Kazushige Wakuda, Akira Ono, Tateaki Naito, Haruyasu Murakami …

CLINICAL LUNG CANCER, 18(5) 519-+, Sep, 2017 Peer-reviewed
Comprehensive characterization of genes associated with the TP53 signal transduction pathway in various tumors

Shumpei Ohnami, Keiichi Ohshima, Takeshi Nagashima, Kenichi Urakami, Yuji Shimoda, Junko Saito, Akane Naruoka, Keiichi Hatakeyama, Tohru Mochizuki, Masakuni Serizawa …

MOLECULAR AND CELLULAR BIOCHEMISTRY, 431(1-2) 75-85, Jul, 2017 Peer-reviewed
Plasma epidermal growth factor receptor mutation testing with a chip-based digital PCR system in patients with advanced non-small cell lung cancer

Norimitsu Kasahara, Hirotsugu Kenmotsu, Masakuni Serizawa, Rina Umehara, Akira Ono, Yasushi Hisamatsu, Kazushige Wakuda, Shota Omori, Kazuhisa Nakashima, Tetsuhiko Taira …

LUNG CANCER, 106 138-144, Apr, 2017 Peer-reviewed
Whole exome sequencing detects variants of genes that mediate response to anticancer drugs

Sumiko Ohnami, Takeshi Nagashima, Kenichi Urakami, Yuji Shimoda, Fukumi Kamada, Junko Saito, Akane Naruoka, Masakuni Serizawa, Yoko Masuda, Shumpei Ohnami …

JOURNAL OF TOXICOLOGICAL SCIENCES, 42(2) 137-144, Apr, 2017 Peer-reviewed
Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplificationdependent overexpression in 1,454 solid tumors

Keiichi Ohshima, Keiichi Hatakeyama, Takeshi Nagashima, Yuko Watanabe, Kaori Kanto, Yuki Doi, Tomomi Ide, Yuji Shimoda, Tomoe Tanabe, Sumiko Ohnami …

SCIENTIFIC REPORTS, 7(1) 641, Apr, 2017 Peer-reviewed
Comprehensive analysis of gene mutation and expression profiles in neuroendocrine carcinomas of the stomach

Rie Makuuchi, Masanori Terashima, Masatoshi Kusuhara, Takashi Nakajima, Masakuni Serizawa, Keiichi Hatakeyama, Keiichi Ohshima, Kenichi Urakami, Ken Yamaguchi

BIOMEDICAL RESEARCH-TOKYO, 38(1) 19-27, 2017 Peer-reviewed
Metabolic profiling of gemcitabine- and paclitaxel-treated immortalized human pancreatic cell lines with K-RAS(G12D)

Akiko Todaka, Rina Umehara, Keiko Sasaki, Masakuni Serizawa, Kenichi Urakami, Masatoshi Kusuhara, Ken Yamaguchi, Hirofumi Yasui

BIOMEDICAL RESEARCH-TOKYO, 38(1) 29-40, 2017 Peer-reviewed
Germline and somatic genetic changes in multicentric tumors obtained from a patient with multiple endocrine neoplasia type 1.

Naruoka A, Ohnami S, Nagashima T, Serizawa M, Ohshima K, Ohnami S, Urakami K, Horiuchi Y, Kiyozumi Y, Abe M …

Human genome variation, 4 17013, 2017 Peer-reviewed
Frequency of EGFR T790M mutation and multimutational profiles of rebiopsy samples from non-small cell lung cancer developing acquired resistance to EGFR tyrosine kinase inhibitors in Japanese patients

Ryo Ko, Hirotsugu Kenmotsu, Masakuni Serizawa, Yasuhiro Koh, Kazushige Wakuda, Akira Ono, Tetsuhiko Taira, Tateaki Naito, Haruyasu Murakami, Mitsuhiro Isaka …

BMC CANCER, 16(1) 864, Nov, 2016 Peer-reviewed
Drastic initial response and subsequent response to two ALK inhibitors in a patient with a highly aggressive ALK-rearranged inflammatory myofibroblastic tumor arising in the pleural cavity

Akira Ono, Haruyasu Murakami, Masakuni Serizawa, Kazushige Wakuda, Hirotsugu Kenmotsu, Tateaki Naito, Tetsuhiko Taira, Yasuhiro Koh, Yasuhisa Ohde, Takashi Nakajima …

LUNG CANCER, 99 151-154, Sep, 2016 Peer-reviewed
Prospective Analysis of Oncogenic Driver Mutations and Environmental Factors: Japan Molecular Epidemiology for Lung Cancer Study

Tomoya Kawaguchi, Yasuhiro Koh, Masahiko Ando, Norimasa Ito, Sadanori Takeo, Hirofumi Adachi, Tsutomu Tagawa, Seiichi Kakegawa, Motohiro Yamashita, Kazuhiko Kataoka …

JOURNAL OF CLINICAL ONCOLOGY, 34(19) 2247-+, Jul, 2016 Peer-reviewed
Novel Tumor-specific Mutations in Receptor Tyrosine Kinase Subdomain IX Significantly Reduce Extracellular Signal-regulated Kinase Activity

Masakuni Serizawa, Masatoshi Kusuhara, Sumiko Ohnami, Takeshi Nagashima, Yuji Shimoda, Keiichi Ohshima, Tohru Mochizuki, Kenichi Urakami, Ken Yamaguchi

ANTICANCER RESEARCH, 36(6) 2733-2744, Jun, 2016 Peer-reviewed
Next generation sequencing approach for detecting 491 fusion genes from human cancer

Kenichi Urakami, Yuji Shimoda, Keiichi Ohshima, Takeshi Nagashima, Masakuni Serizawa, Tomoe Tanabe, Junko Saito, Tamiko Usui, Yuko Watanabe, Akane Naruoka …

BIOMEDICAL RESEARCH-TOKYO, 37(1) 51-62, 2016 Peer-reviewed
Prevalence of low-penetrant germline TP53 D49H mutation in Japanese cancer patients

Ken Yamaguchi, Kenichi Urakami, Takeshi Nagashima, Yuji Shimoda, Shumpei Ohnami, Sumiko Ohnami, Keiichi Ohshima, Tohru Mochizuki, Keiichi Hatakeyama, Masakuni Serizawa …

BIOMEDICAL RESEARCH-TOKYO, 37(4) 259-264, 2016 Peer-reviewed
Optimizing an ion semiconductor sequencing data analysis method to identify somatic mutations in the genomes of cancer cells in clinical tissue samples

Takeshi Nagashima, Yuji Shimoda, Tomoe Tanabe, Akane Naruoka, Junko Saito, Masakuni Serizawa, Keiichi Ohshima, Kenichi Urakami, Sumiko Ohnami, Shumpei Ohnami …

BIOMEDICAL RESEARCH-TOKYO, 37(6) 359-366, 2016 Peer-reviewed
Integrated next-generation sequencing analysis of whole exome and 409 cancer-related genes

Yuji Shimoda, Takeshi Nagashima, Kenichi Urakami, Tomoe Tanabe, Junko Saito, Akane Naruoka, Masakuni Serizawa, Tohru Mochizuki, Keiichi Ohshima, Sumiko Ohnami …

BIOMEDICAL RESEARCH-TOKYO, 37(6) 367-379, 2016 Peer-reviewed

Awards

2011

平成23年度海外派遣研究助成金, がん研究振興財団

芹澤昌邦

Misc.

バイオバンクと個別化医療

芹澤昌邦, 洪泰浩

PROGRESS IN MEDICINE, 31(11) 2575-2580, 2011

Research Projects

がんゲノム解析で蓄積する機能未知遺伝子変異の臨床活用にむけた変異機能推定法の構築

科研費基盤(C), 日本学術振興会, Apr, 2019 - Mar, 2022

芹澤昌邦
肺癌治療におけるEGFR-TKI耐性克服にむけた代謝経路を標的とする治療法の開発

科研費基盤(C), 日本学術振興会, Apr, 2015 - Mar, 2018

芹澤昌邦
非小細胞肺癌におけるEGFR-TKI治療耐性化後の転移に関する新規分子機序の解明

科研費若手研究(B), 日本学術振興会, Apr, 2013 - Mar, 2015

芹澤昌邦
胸部悪性腫瘍における分子生物学的診断の試みと新規バイオマーカーの探索研究

科研費基盤(C), 日本学術振興会, Apr, 2012 - Mar, 2015

山本信之
GLUT1を新規治療効果予測マーカーに用いた肺がんの個別化医療の実現にむけた研究

科研費若手研究(B), 日本学術振興会, Apr, 2011 - Mar, 2013

芹澤昌邦
枯草菌における転写制御系についての解析

特別研究員奨励費, 日本学術振興会, Apr, 2003 - Mar, 2005

芹澤昌邦