論文

国際誌
2020年6月18日

Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse.

Nature communications
  • Anastasiia Bondarieva
  • ,
  • Kavya Raveendran
  • ,
  • Vladyslav Telychko
  • ,
  • H B D Prasada Rao
  • ,
  • Ramya Ravindranathan
  • ,
  • Chrysoula Zorzompokou
  • ,
  • Friederike Finsterbusch
  • ,
  • Ihsan Dereli
  • ,
  • Frantzeskos Papanikos
  • ,
  • Daniel Tränkner
  • ,
  • Alexander Schleiffer
  • ,
  • Ji-Feng Fei
  • ,
  • Anna Klimova
  • ,
  • Masaru Ito
  • ,
  • Dhananjaya S Kulkarni
  • ,
  • Ingo Roeder
  • ,
  • Neil Hunter
  • ,
  • Attila Tóth

11
1
開始ページ
3101
終了ページ
3101
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41467-020-16885-3

Orderly chromosome segregation is enabled by crossovers between homologous chromosomes in the first meiotic division. Crossovers arise from recombination-mediated repair of programmed DNA double-strand breaks (DSBs). Multiple DSBs initiate recombination, and most are repaired without crossover formation, although one or more generate crossovers on each chromosome. Although the underlying mechanisms are ill-defined, the differentiation and maturation of crossover-specific recombination intermediates requires the cyclin-like CNTD1. Here, we identify PRR19 as a partner of CNTD1. We find that, like CNTD1, PRR19 is required for timely DSB repair and the formation of crossover-specific recombination complexes. PRR19 and CNTD1 co-localise at crossover sites, physically interact, and are interdependent for accumulation, indicating a PRR19-CNTD1 partnership in crossing over. Further, we show that CNTD1 interacts with a cyclin-dependent kinase, CDK2, which also accumulates in crossover-specific recombination complexes. Thus, the PRR19-CNTD1 complex may enable crossover differentiation by regulating CDK2.

リンク情報
DOI
https://doi.org/10.1038/s41467-020-16885-3
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32555348
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303132
ID情報
  • DOI : 10.1038/s41467-020-16885-3
  • PubMed ID : 32555348
  • PubMed Central 記事ID : PMC7303132

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