Mimi Adachi

Profile Information

Affiliation: Professor (Professor and Chairman), Faculty of Medicine, Teikyo University

Degree: 医学博士(東京医科歯科大学)

J-GLOBAL ID: 201301002467394200
researchmap Member ID: B000232916

External link: http://kaken.nii.ac.jp/d/r/10323693.ja.html

Research Interests

Research Areas

Research History

Apr, 2020 - Present

Professor (Professor and Chairman), Department of Biochemistry, Teikyo University School of Medicine
Dec, 2018 - Present

School of Medicine, Teikyo University
Apr, 2013 - Nov, 2018

Associate Professor, Department of Biochemistry, Teikyo University School of Medicine
Apr, 2013 - Nov, 2018

School of Medicine, Teikyo University
Apr, 2010 - Mar, 2013

Lecturer, Department of Biochemistry, Teikyo University School of Medicine
Apr, 2010 - Mar, 2013

School of Medicine, Teikyo University
Jan, 2009 - Mar, 2010

Visiting Scientist, Department of Molecular Biology, Cell Biology and Biochemistry Laboratories for Molecular Medicine, Brown University
Apr, 2007 - Mar, 2010

Medical Research Institute, Tokyo Medical and Dental University
Jan, 2000 - Mar, 2010

Assistant Professor, Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University
Jan, 2000 - Mar, 2007

Medical Research Institute, Tokyo Medical and Dental University
Apr, 1997 - Jan, 2000

Fellow, Grant-in-Aid for Japan Society for the Promotion of Science (JSPS)
Apr, 1997 - Jan, 2000

特別研究員, 文部省学術振興会
Apr, 1996 - Mar, 1997

Medical Doctor, the 2nd Department of Internal Medicine, Tokyo Medical and Dental University
Apr, 1996 - Mar, 1997

Tokyo Medical and Dental University
Jun, 1991 - Mar, 1992

Medical Doctor, the Department of Internal Medicine, Tsuchiura General Hospital
Jun, 1991 - Mar, 1992

研修医, 内科, 土浦協同病院内科
May, 1990 - May, 1991

Resident, the 2nd Department of Internal Medicine, Tokyo Medical and Dental University
May, 1990 - May, 1991

Tokyo Medical and Dental University

Education

Apr, 1992 - Mar, 1996

PhD., Internal Medicine, Tokyo Medical and Dental University
Apr, 1992 - Mar, 1996

Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Mar, 1996

医学博士
Apr, 1984 - Mar, 1990

M.D., Tokyo Medical and Dental University
Apr, 1984 - Mar, 1990

School of Medicine, Faculty of Medicine, Tokyo Medical and Dental University

Awards

Apr, 2004

東京医科歯科大学研究奨励賞, 東京医科歯科大学

安達三美

Papers

Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway.

Miho Akimoto, Takao Susa, Noriyuki Okudaira, Nobuko Koshikawa, Harumi Hisaki, Masayoshi Iizuka, Hiroko Okinaga, Keizo Takenaga, Tomoki Okazaki, Mimi Tamamori-Adachi

Proceedings of the National Academy of Sciences of the United States of America, 120(18) e2218033120, May 2, 2023 Peer-reviewed
A Novel LncRNA PTH-AS Upregulates Interferon-Related DNA damage resistance Signature genes and Promotes Metastasis in Human Breast Cancer Xenografts.

Miho Akimoto, Takao Susa, Noriyuki Okudaira, Harumi Hisaki, Masayoshi Iizuka, Hiroko Okinaga, Tomoki Okazaki, Mimi Tamamori-Adachi

The Journal of biological chemistry, 102065-102065, May 23, 2022 Peer-reviewed
Resveratrol blocks retrotransposition of LINE-1 through PPAR α and sirtuin-6.

Noriyuki Okudaira, Yukihito Ishizaka, Mimi Tamamori-Adachi

Scientific reports, 12(1) 7772-7772, May 11, 2022 Peer-reviewed
ヒト前立腺癌細胞にてDHTで抑制されるHOXC9はARの阻害因子として機能する

諏佐崇生, 秋元美穂, 奥平准之, 飯塚眞由, 岡崎具樹, 安達三美

日本内分泌学会雑誌, 98(1) 295-295, Apr, 2022
25(OH)D3 stimulates the expression of vitamin D target genes in renal tubular cells when Cyp27b1 is abrogated.

Takahiro Kikuyama, Takao Susa, Mimi Tamamori-Adachi, Masayoshi Iizuka, Miho Akimoto, Hiroko Okinaga, Yoshihide Fujigaki, Shunya Uchida, Shigeru Shibata, Tomoki Okazaki

The Journal of steroid biochemistry and molecular biology, 199 105593-105593, Jan 13, 2020 Peer-reviewed
Without 1α-hydroxylation, the gene expression profile of 25(OH)D3 treatment overlaps deeply with that of 1,25(OH)2D3 in prostate cancer cells

Takao Susa, Masayoshi Iizuka, Hiroko Okinaga, Mimi Tamamori-Adachi, Tomoki Okazaki

Scientific Reports, 8(1) 9024, Dec 1, 2018 Peer-reviewed
DNA damage response induced by Etoposide promotes steroidogenesis via GADD45A in cultured adrenal cells.

Tamamori-Adachi M, Koga A, Susa T, Fujii H, Tsuchiya M, Okinaga H, Hisaki H, Iizuka M, Kitajima S, Okazaki T

Scientific reports, 8(1) 9636, Jun, 2018 Peer-reviewed
ヒト前立腺癌LNCaP細胞における25(OH)D3のビタミンD3活性の評価

諏佐崇生, 飯塚眞由, 安達三美, 岡崎具樹

日本内分泌学会雑誌, 94(1) 369-369, Apr, 2018
ヒト前立腺癌LNCaP細胞において25(OH)D3は1,25(OH)2D3の標的遺伝子と類似した遺伝子群を制御する

諏佐崇生, 飯塚眞由, 安達三美, 岡崎具樹

生命科学系学会合同年次大会, 2017年度 [2P-0434], Dec, 2017
Intrinsic ubiquitin E3 ligase activity of histone acetyltransferase Hbo1 for estrogen receptor alpha

Masayoshi Iizuka, Takao Susa, Mimi Tamamori-Adachi, Hiroko Okinaga, Tomoki Okazaki

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 93(7) 498-510, Jul, 2017 Peer-reviewed
An Excess of CYP24A1, Lack of CaSR, and a Novel lncRNA Near the PTH Gene Characterize an Ectopic PTH-Producing Tumor.

Kosuke Uchida, Yuji Tanaka, Hitoshi Ichikawa, Masato Watanabe, Sachiyo Mitani, Koji Morita, Hiroko Fujii, Mayumi Ishikawa, Gen Yoshino, Hiroko Okinaga …

Journal of the Endocrine Society, 1(6) 691-711, Jun 1, 2017 Peer-reviewed
Wild-type and Specific Mutant Androgen Receptor Mediates Transcription via 17 beta-Estradiol in Sex Hormone-sensitive Cancer Cells

Takao Susa, Reina Ikaga, Takashi Kajitani, Masayoshi Iizuka, Hiroko Okinaga, Mimi Tamamori-Adachi, Tomoki Okazaki

JOURNAL OF CELLULAR PHYSIOLOGY, 230(7) 1594-1606, Jul, 2015 Peer-reviewed
Marked Cortisol Production by Intracrine ACTH in GIP-Treated Cultured Adrenal Cells in Which the GIP Receptor Was Exogenously Introduced

Hiroko Fujii, Mimi Tamamori-Adachi, Kousuke Uchida, Takao Susa, Takashi Nakakura, Haruo Hagiwara, Masayoshi Iizuka, Hiroko Okinaga, Yuji Tanaka, Tomoki Okazaki

PLOS ONE, 9(10) e110543, Oct, 2014 Peer-reviewed
Histone acetyltransferase Hbo1 destabilizes estrogen receptor α by ubiquitination and modulates proliferation of breast cancers.

Masayoshi Iizuka, Takao Susa, Yoshihisa Takahashi, Mimi Tamamori-Adachi, Takashi Kajitani, Hiroko Okinaga, Toshio Fukusato, Tomoki Okazaki

Cancer science, 104(12) 1647-55, Dec, 2013 Peer-reviewed
Histone acetyltransferase Hbo1 destabilizes estrogen receptor a by ubiquitination and modulates proliferation of breast cancers

Masayoshi Iizuka, Takao Susa, Yoshihisa Takahashi, Mimi Tamamori-Adachi, Takashi Kajitani, Hiroko Okinaga, Toshio Fukusato, Tomoki Okazaki

CANCER SCIENCE, 104(12) 1647-1655, Dec, 2013 Peer-reviewed
Primary polydipsia, but not accumulated ceramide, causes lethal renal damage in saposin D-deficient mice

Harumi Hisaki, Junko Matsuda, Keiko Tadano-Aritomi, Shunya Uchida, Hiroko Okinaga, Makoto Miyagawa, Mimi Tamamori-Adachi, Masayoshi Iizuka, Tomoki Okazaki

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 303(7) F1049-F1059, Oct, 2012 Peer-reviewed
Primary polydipsia, but not accumulated ceramide, causes lethal renal damage in saposin D-deficient mice

Harumi Hisaki, Junko Matsuda, Keiko Tadano-Aritomi, Shunya Uchida, Hiroko Okinaga, Makoto Miyagawa, Mimi Tamamori-Adachi, Masayoshi Iizuka, Tomoki Okazaki

American Journal of Physiology - Renal Physiology, 303(7) F1049-F1059, Oct 1, 2012 Peer-reviewed
Degradation of p21(Cip1) through Anaphase-promoting Complex/Cyclosome and Its Activator Cdc20 (APC/C-Cdc20) Ubiquitin Ligase Complex-mediated Ubiquitylation Is Inhibited by Cyclin-dependent Kinase 2 in Cardiomyocytes

Kazuhiko Yamada, Mimi Tamamori-Adachi, Ikuko Goto, Masayoshi Iizuka, Takashi Yasukawa, Teijiro Aso, Tomoki Okazaki, Shigetaka Kitajima

JOURNAL OF BIOLOGICAL CHEMISTRY, 286(51) 44057-44066, Dec, 2011 Peer-reviewed
Nuclear protein accumulation in cellular senescence and organismal aging revealed with a novel single-cell resolution fluorescence microscopy assay

Marco De Cecco, Jessie Jeyapalan, Xiaoai Zhao, Mimi Tamamori-Adachi, John M. Sedivy

AGING-US, 3(10) 955-967, Oct, 2011 Peer-reviewed
Systems Analysis of ATF3 in Stress Response and Cancer Reveals Opposing Effects on Pro-Apoptotic Genes in p53 Pathway

Yujiro Tanaka, Aya Nakamura, Masaki Suimye Morioka, Shoko Inoue, Mimi Tamamori-Adachi, Kazuhiko Yamada, Kenji Taketani, Junya Kawauchi, Miki Tanaka-Okamoto, Jun Miyoshi …

PLOS ONE, 6(10) e26848, Oct, 2011 Peer-reviewed

Misc.

ヒト前立腺癌LNCaP細胞における25(OH)D3のビタミンD3活性の評価

諏佐崇生, 飯塚眞由, 安達三美, 岡崎具樹

日本内分泌学会雑誌, 94(1) 369-369, Apr, 2018
Marked Cortisol Production By Intracrine ACTH in Gip-Treated Cultured Adrenal Cells in Which Gip Receptor Was Exogenously Introduced

Hiroko Fujii, Mimi Tamamori-Adachi, Takao Susa, Masayoshi Iizuka, Yuji Tanaka, Tomoki Okazaki

ENDOCRINE REVIEWS, 35(3), Jun, 2014
Aberrant, but Physiological, Interactions Between the Non-Mutated Androgen Receptor and E2 in Several Sex Hormone-Responsive Cancer Cells

Takao Susa, Reina Ikaga, Takashi Kajitani, Masayoshi Iizuka, Mimi Tamamori-Adachi, Tomoki Okazaki

ENDOCRINE REVIEWS, 35(3), Jun, 2014
Serine 21 Phosphorylation of GSK-3 alpha Mediates Myocyte Proliferation through CyclinD1/E2F Pathway under Pressure Overload

Takahisa Matsuda, Pelyong Zhai, Chull Hong, Shumin Gao, Bin Tian, Kazumichi Goto, Mimi Tamamori-Adachi, Hiromitsu Takagi, Junichi Sadoshima

CIRCULATION, 118(18) S327-S327, Oct, 2008
Important Role of Basic Fibroblast Growth Factor Signaling and p27kip1 in Adult Cardiomyocyte Cell Cycle Regulation

Yasuhiro Maejima, Mimi Tamamori-Adachi, Kazuhiko Yamada, Susumu Adachi, Shigetaka Kitajima, Mitsuaki Isobe

CIRCULATION, 118(18) S429-S429, Oct, 2008
Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation

S Kitajima, K Tamura, H Bayin, S Adachi, Guney, I, MT Adachi, Y Tanaka, JM Sedivy

FASEB JOURNAL, 20(4) A37-A37, Mar, 2006
Nuclear localization signal-tagged cyclin D1/cdk4/skp2 gene transfer prevents left ventricular dysfunction and heart failure after myocardial infarction in rats

H Takagi, T Hidaka, U Koshimizu, N Inomata, M Tamamori-Adachi, J Kawauchi, S Kitajima

CIRCULATION, 112(17) U145-U145, Oct, 2005
CyclinD1 and CDK4 induce hypertrophy through phosphorylation of RNA polymerase II C-terminal domain in neonatal rat cardiomyocytes

K Nobori, M Tamamori-Adachi, H Ito, K Hayashida, J Kawauchi, S Adachi, M Isobe, S Kitajima

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 35(11) A27-A27, Nov, 2003
Nitric oxide inhibits hypoxia/reoxygenation-induced myocardial apoptosis by modulating cyclin A-associated kinase activity

Y Maejima, S Adachi, K Morikawa, K Nobori, M Tamamori-Adachi, M Isobe, H Ito

CIRCULATION, 108(17) 64-64, Oct, 2003
Overexpression of ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes

K Nobori, H Ito, M Tamamori-Adachi, S Adachi, Y Ono, Y Maejima, J Kawauchi, S Kitajima, M Isobe

CIRCULATION, 106(19) 92-93, Nov, 2002
Induction of cardiac muscle cell proliferatrion by transport of cyclin D1/CDK4 to nucleus

M Tamamori-Adachi, H Ito, S Adachi, M Hiroe, J Kawauchi, M Shimizu, S Kitajima, M Ikeda

CIRCULATION, 106(19) 204-204, Nov, 2002
Transcriptional repressor ATF3 protects human umbilical vein endothelial cells from TNF-alpha-induced apoptosis through down-regulation of p53 transcription

J Kawauchi, K Nobori, M Tamamori-Adachi, M Sunamori, S Kitajima

CIRCULATION, 106(19) 288-288, Nov, 2002
Expression of transcriptional repressor ATF3 in human atherosclerosis: Co-localization and significance in cell death of vascular endothelial cells

T Nawa, MT Nawa, MT Adachi, Uchimura, I, K Fujisawa, A Tanaka, F Numano, S Kitajima

DIABETES, 50 A162-A162, Jun, 2001
Endothelin-1 supresses nitric oxide induced caspase-3 activation and antagonizes apoptosis in cardiomyocytes

M Hiroe, M Shichiri, S Ishiyama, T Shimojo, S Abe, S Adachi, M Tamamori, H Ito, Y Hirata, F Marumo

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35(2) 170A-170A, Feb, 2000
Angiotensin II- or endothelin-1-induced cardiomyocyte hypertrophy is regulated by G1 cyclin-cdk complex via Rb phosphorylation

T Nozato, H Ito, M Tamamori, Y Ono, T Shimojo, S Adachi, S Abe, F Marumo, M Hiroe

CIRCULATION, 100(18) 353-353, Nov, 1999
Overexpression of cdk inhibitor p16(INK4) by adenovirus vector inhibits cardiac hypertrophy induced by aortic banding in rats

H Ito, M Watatanbe, T Nozato, M Tamamori, S Adachi, H Tanaka, M Sunamori, F Marumo, M Hiroe

CIRCULATION, 100(18) 688-689, Nov, 1999
Cyclin D1 is a key factor in hypertrophy of cardiomyocytes

T Notato, H Ito, M Tamamori, S Adachi, S Abe, F Marumo, M Hiroe

CIRCULATION, 98(17) 626-626, Oct, 1998
Involvement of G1 cell cycle regulators in the development of cardiomyocyte hypertrophy

M Tamamori, H Ito, M Ikeda, S Adachi, S Abe, H Akimoto, F Marumo, M Hiroe

CIRCULATION, 94(8) 910-910, Oct, 1996
ROLE OF HEPARIN-LIKE MOLECULES IN THE REGULATION OF CARDIAC-HYPERTROPHY

H AKIMOTO, H ITO, S ADACHI, H FUJISAKI, M TANAKA, M HATA, F MARUMO, M HIROE

CIRCULATION, 92(8) 299-299, Oct, 1995
MILD HYPOXIA-INDUCED HYPERTROPHY OF CARDIAC MYOCYTES IS INHIBITED BY RECEPTOR ANTAGONIST FOR ENDOTHELIN BUT NOT FOR ANGIOTENSIN

H ITO, M HIROE, M TANAKA, S ADACHI, H AKIMOTO, M HATA, MH LIN, F MARUMO

CIRCULATION, 90(4) 371-371, Oct, 1994

Books and Other Publications

実験医学2013年12月増刊号老化・寿命研究の最前線

安達(玉盛)三美, 岡崎具樹, Kleiling JA, Sedivy JM (Role: Contributor, 個体でみられる細胞老化)

羊土社, 2013
心筋症を識る・診る・治す

安達三美 (Role: Contributor, Topics 心筋細胞の再分裂誘導は可能か)

文光堂, 2007
キーワードで理解する細胞周期イラストマップ

安達三美, 北嶋繁孝 (Role: Contributor, 再生と細胞周期)

羊土社, 2005
分子細胞治療

安達三美, 北嶋繁孝 (Role: Contributor, 心筋細胞の再生を目指した細胞周期機構の解明)

先端医学社, 2004
発生における細胞増殖制御

池田正明, 安達三美 (Role: Contributor, 心筋の増殖停止機構)

シュプリンガー・フェアラーク東京, 2004
「実験医学」Vol. 21 No. 5（増刊）

池田正明, 安達三美 (Role: Contributor, サイクリンD1の核移行制御と心筋細胞の増殖)

羊土社, 2003
心臓における生命現象の分子生物学

玉盛三美, 伊藤宏 (Role: Contributor, 心筋細胞と細胞周期)

メディカルレビュー社, 2001
細胞外マトリックス研究法（４）

玉盛三美, 伊藤宏 (Role: Contributor, 組織からの細胞分離と培養系の確立、心筋細胞、心線維芽細胞)

コラーゲン技術研修会, 1999

Research Projects

副腎の老化の制御による個体老化のコントロールと健康長寿を目指す研究

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

安達三美
糖質コルチコイド制御による、老化のコントロールを目指す研究

基盤研究C, 科研費, Apr, 2019 - Mar, 2022

安達三美
加齢による糖質コルチコイド合成系の変化と老化への影響の解析

基盤研究C, 科研費, 2015 - 2018

安達三美
老化組織におけるヘテロクロマチン構造の解析と新規バイオマーカーの探索

基盤研究C, 科研費, 2011 - 2014

安達三美
細胞周期制御因子による心筋再生療法の開発を目指した研究

基盤研究C, 科研費, 2007 - 2008

安達三美
bZip型転写抑制因子ATF3の細胞増殖と細胞死デコードシステムの解析

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

北嶋繁孝, 安達三美
c-Myc標的遺伝子ATF3の細胞増殖と発がんに関する研究

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

北嶋繁孝, 安達三美
サイクリンD1の心筋特異的核内発現によるヒト心筋細胞再生法の開発

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2005 - 2006

北嶋繁孝, 砂盛誠, 磯部光章, 安達三美
心筋再分裂誘導の分子機構と再生治療への応用に関する研究

基盤研究C, 科研費, 2005 - 2006

安達三美
心筋の再生を目指した細胞周期機構の解明

基盤研究C, 科研費, 2003 - 2004

安達三美
Alternations of Transcriptional Regulation in Oral Cancers and Analysis of Tumor Suppressive functions of p300 Transcriptional Co-activator

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2003

IKEDA Masa-aki, IKEDA Yayoi, ADACHI Mimi
心筋細胞の増殖抑制メカニズムの解明：心筋再生を目指して

報彰基金研究奨励, 財団法人武田化学振興財団, 2003

安達三美
心筋細胞における細胞周期の解明；心筋細胞の再生を目指して

奨励研究A, 科研費, 2001 - 2002

安達三美
Alternations of the Transcriptional Co-activator p300 in Oral Cancers and Its Novel Role in Tumor Suppression

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1998 - 2000

IKEDA Masa-aki, IKEDA Yayoi, ADACHI Mimi
心筋細胞肥大における細胞周期制御機構の関与について

特別研究員奨励費, 科研費, 1997 - 1999

安達三美

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Papers

Misc.

Books and Other Publications

Research Projects

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