論文

国際誌
2020年11月

Stiffness of the extracellular matrix regulates differentiation into beige adipocytes

Biochemical and Biophysical Research Communications
  • Kyoko Takata
  • ,
  • Tsuyoshi Goto
  • ,
  • Mito Kuroda
  • ,
  • Yasuhisa Kimura
  • ,
  • Ichiro Harada
  • ,
  • Kazumitsu Ueda
  • ,
  • Teruo Kawada
  • ,
  • Noriyuki Kioka

532
2
開始ページ
205
終了ページ
210
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2020.08.032
出版者・発行元
Elsevier {BV}

Beige/brite adipocytes, which express high levels of uncoupling protein 1 (UCP1) to generate heat using stored triglycerides, are induced under specific stimuli such as cold exposure in inguinal white adipose tissue (iWAT). Although extracellular microenvironments such as extracellular matrix (ECM) stiffness are known to regulate cell behaviors, including cell differentiation into adipocytes, the effect on iWAT cells is unknown. In this study, we show that rigid ECM promotes the cell spreading of iWAT-derived preadipocytes. Furthermore, the expression of UCP1 and other thermogenic genes in iWAT cells is promoted when the cells are cultured on rigid ECM. The expression of mTOR, a kinase known to regulate the differentiation to beige adipocytes, is decreased on rigid substrates. These results suggest that ECM stiffness plays an important role in the differentiation to beige adipocytes.

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2020.08.032
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32859378
ID情報
  • DOI : 10.1016/j.bbrc.2020.08.032
  • ORCIDのPut Code : 79379208
  • PubMed ID : 32859378

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