宮下知之 (Tomoyuki Miyashita) - マイポータル

基本情報

所属: 財団法人東京都医学総合研究所認知症・高次脳機能研究分野学習・記憶プロジェクト主席研究員

学位: 農学博士(日本大学)
Ph D

研究者番号: 70270668
J-GLOBAL ID: 200901032261240480
researchmap会員ID: 0000007007

外部リンク: http://www.igakuken.or.jp/memory/

修士終了後に東京都神経科学総合研究所に就職、久保義弘研究員（現生理学研究所教授）の下で学位を取得。現在、東京都医学総合研究所（平成23年から神経研、精神研、臨床研が統合）の
学習・記憶プロジェクト（齊藤研究室）で、ショウジョウバエを用いた学習、記憶の分子メカニズムについて研究中。

研究キーワード

研究分野

ライフサイエンス / 神経科学一般 /

論文

A non-canonical on-demand dopaminergic transmission underlying olfactory aversive learning.

Minoru Saitoe, Shintaro Naganos, Tomoyuki Miyashita, Motomi Matsuno, Kohei Ueno

Neuroscience research 178 1-9 2022年5月
Dopamine modulates the optomotor response to unreliable visual stimuli in Drosophila melanogaster.

Masumi Akiba, Kentaro Sugimoto, Risa Aoki, Ryo Murakami, Tomoyuki Miyashita, Riho Hashimoto, Anna Hiranuma, Junji Yamauchi, Taro Ueno, Takako Morimoto

The European journal of neuroscience 51(3) 822-839 2019年12月13日査読有り
Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling.

Tomoyuki Miyashita, Emi Kikuchi, Junjiro Horiuchi, Minoru Saitoe

Cell reports 25(10) 2716-2728 2018年12月4日査読有り
Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.

Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M

The Journal of biological chemistry 291(11) 5473-5483 2016年3月査読有り
Long-Term Memory Formation in Drosophila Requires Training-Dependent Glial Transcription

Motomi Matsuno, Junjiro Horiuchi, Yoshihiro Yuasa, Kyoko Ofusa, Tomoyuki Miyashita, Tomoko Masuda, Minoru Saitoe

JOURNAL OF NEUROSCIENCE 35(14) 5557-5565 2015年4月査読有り
Glial Dysfunction Causes Age-Related Memory Impairment in Drosophila

Daisuke Yamazaki, Junjiro Horiuchi, Kohei Ueno, Taro Ueno, Shinjiro Saeki, Motomi Matsuno, Shintaro Naganos, Tomoyuki Miyashita, Yukinori Hirano, Hiroyuki Nishikawa, Masato Taoka, Yoshio Yamauchi, Toshiaki Isobe, Yoshiko Honda, Tohru Kodama, Tomoko Masuda, Minoru Saitoe

NEURON 84(4) 753-763 2014年11月査読有り
Fasting launches CRTC to facilitate long-term memory formation in Drosophila.

Yukinori Hirano, Tomoko Masuda, Shintaro Naganos, Motomi Matsuno, Kohei Ueno, Tomoyuki Miyashita, Junjiro Horiuchi, Minoru Saitoe

Science (New York, N.Y.) 339(6118) 443-6 2013年1月25日査読有り
Mg2+ Block of Drosophila NMDA Receptors Is Required for Long-Term Memory Formation and CREB-Dependent Gene Expression

Tomoyuki Miyashita, Yoshiaki Oda, Junjiro Horiuchi, Jerry C. P. Yin, Takako Morimoto, Minoru Saitoe

NEURON 74(5) 887-898 2012年6月査読有り
Reactive oxygen species are not involved in the onset of age-related memory impairment in Drosophila

Y. Hirano, Y. Kuriyama, T. Miyashita, J. Horiuchi, M. Saitoe

GENES BRAIN AND BEHAVIOR 11(1) 79-86 2012年2月査読有り
Acute Inhibition of PKA Activity at Old Ages Ameliorates Age-Related Memory Impairment in Drosophila

Daisuke Yamazaki, Junjiro Horiuchi, Tomoyuki Miyashita, Minoru Saitoe

JOURNAL OF NEUROSCIENCE 30(46) 15573-15577 2010年11月査読有り
Drosophila PQBP1 Regulates Learning Acquisition at Projection Neurons in Aversive Olfactory Conditioning

Takuya Tamura, Daisuke Horiuchi, Yi-Chung Chen, Masaki Sone, Tomoyuki Miyashita, Minoru Saitoe, Natsue Yoshimura, Ann-Shyn Chiang, Hitoshi Okazawa

JOURNAL OF NEUROSCIENCE 30(42) 14091-14101 2010年10月査読有り
Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73

M Hoshino, ML Qi, N Yoshimura, T Miyashita, K Tagawa, Y Wada, Y Enokido, S Marubuchi, P Harjes, N Arai, K Oyanagi, G Blandino, M Sudol, T Rich, Kanazawa, I, EE Wanker, M Saitoe, H Okazawa

JOURNAL OF CELL BIOLOGY 172(4) 589-604 2006年2月査読有り
NMDA receptors mediate olfactory learning and memory in Drosophila

SZ Xia, T Miyashita, TF Fu, WY Lin, CL Wu, L Pyzocha, IR Lin, M Saitoe, T Tully, AS Chiang

CURRENT BIOLOGY 15(7) 603-615 2005年4月査読有り
Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology

T Misaka, T Miyashita, Y Kubo

JOURNAL OF BIOLOGICAL CHEMISTRY 277(18) 15834-15842 2002年5月査読有り
Extracellular Ca2+ sensitivity of mGluR1 alpha induces an increase in the basal cAMP level by direct coupling with Gs protein in transfected CHO cells

T Miyashita, Y Kubo

RECEPTORS & CHANNELS 7(2) 77-+ 2000年査読有り
Extracellular Ca2+ sensitivity of mGluR1 alpha associated with persistent glutamate response in transfected CHO cells

T Miyashita, Y Kubo

RECEPTORS & CHANNELS 7(1) 25-40 2000年査読有り
Cloning and characterization of a bifunctional metabotropic receptor activated by both extracellular calcium and glutamate

Kaoru Kubokawa, Tomoyuki Miyashita, Hiromichi Nagasawa, Yoshihiro Kubo

FEBS Letters 392(1) 71-76 1996年8月19日査読有り
A weakly inward rectifying potassium channel of the salmon brain. Glutamate 179 in the second transmembrane domain is insufficient for strong rectification.

Kubo Y, Miyashita T, Kubokawa K

The Journal of biological chemistry 271(26) 15729-15735 1996年6月査読有り

MISC

dPQBP1 is involved in a memory trace at projection neurons

Takuya Tamura, Daisuke Horiuchi, Yi-Chung Chen, Masaki Sone, Tomoyuki Miyashita, Minoru Saitoe, Natsue Yoshimura, Ann-Shyn Chiang, Hitoshi Okazawa

NEUROSCIENCE RESEARCH 68 E186-E186 2010年
Why rest intervals are required for long-term memory formation?

Tomoyuki Miyashita, Minoru Saitoe

NEUROSCIENCE RESEARCH 65 S112-S112 2009年
Proteome analysis of nuclear proteins associated with polyglutamine disease

Mei-Ling Qi, Natsue Yoshimura, Kazuhiko Tagawa, Tomoyuki Miyashita, Hitoshi Okazawa

NEUROSCIENCE RESEARCH 55 S103-S103 2006年
Mg2+ blockade of Drosophila NMDA receptor is required for gene expression for long-term memory and synaptic plasticity

Tomoyuki Miyashita, Tetsuya Yamamoto, Minoru Saitoe

NEUROSCIENCE RESEARCH 55 S110-S110 2006年
Drosophila model for analyzing pathological function of PQBP-1 in mental retardation

Natsue Yoshimura, Daisuke Horiuchi, Tomoyuki Miyashita, Minoru Saitoe, Hitoshi Okazawa

NEUROSCIENCE RESEARCH 55 S167-S167 2006年
Isolation of a cDNA for a novel 120-kDa GTP-binding protein expressed in motor neurons in the salmon brain

K Kubokawa, T Miyashita, Y Kubo

FEBS LETTERS 431(2) 231-235 1998年7月
Structural basis for a Ca2+-Sensing functions of the metabotropic glutamate receptors

Yoshihiro Kubo, Tomoyuki Miyashita, Yoshimichi Murata

Science 279(5357) 1722-1725 1998年3月13日
Localization and developmental changes of the expression of two inward rectifying K+-channel proteins in the rat brain

Tomoyuki Miyashita, Yoshihiro Kubo

Brain Research 750(1-2) 251-263 1997年3月7日

宮下知之

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