SU MEI TZU

Profile Information

Affiliation: Institute of Development,Aging and Cancer, Tohoku University

Researcher number: 00812116
J-GLOBAL ID: 201801011606707851
researchmap Member ID: B000317469

Research Interests

Research Areas

Research History

Apr, 2018 - Present

東北大学加齢医学研究所
Jul, 2017 - Mar, 2018

東北大学加齢医学研究所
Aug, 2015 - Apr, 2017

National Taiwan University

Education

Aug, 2008 - Jun, 2015

国立台湾大学（台湾）

Papers

Fibronectin on target cells attenuates natural cytotoxicity of NK cells via myeloid immune checkpoint ILT3/LILRB4/gp49B

Fumika Itagaki, Keita Nakatsuka, Haruka Sakai, Shota Endo, Mei-Tzu Su, Toshiyuki Takai

International Immunology, 35(7) 339-348, Apr 21, 2023
LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells

Shotaro Miyamoto, Takumi Chiba, So Itoi, Mei-Tzu Su, Toshiyuki Takai

The Tohoku Journal of Experimental Medicine, 259(4) 273-284, 2023
Fibronectin-LILRB4/gp49B interaction negatively regulates osteoclastogenesis through inhibition of RANKL-induced TRAF6/TAK1/NF-kB/MAPK signaling.

Mei-Tzu Su, Karin Ono, Dai Kezuka, Shotaro Miyamoto, Yu Mori, Toshiyuki Takai

International immunology, Nov 4, 2022
Myeloid immune checkpoint ILT3/LILRB4/gp49B can co-tether fibronectin with integrin on macrophages.

So Itoi, Naoyuki Takahashi, Haruka Saito, Yusuke Miyata, Mei-Tzu Su, Dai Kezuka, Fumika Itagaki, Shota Endo, Hiroshi Fujii, Hideo Harigae …

International immunology, 34(8) 435-444, Jul 26, 2022
Co-localization of Fibronectin Receptors LILRB4/gp49B and Integrin on Dendritic Cell Surface

Naoyuki Takahashi, So Itoi, Mei-Tzu Su, Shota Endo, Toshiyuki Takai

The Tohoku Journal of Experimental Medicine, 257(3) 171-180, 2022
LILRB4 promotes tumor metastasis by regulating MDSCs and inhibiting miR-1 family miRNAs.

Mei-Tzu Su, Sakiko Kumata, Shota Endo, Yoshinori Okada, Toshiyuki Takai

Oncoimmunology, 11(1) 2060907-2060907, 2022
Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice.

Mei-Tzu Su, Masanori Inui, Yi Li Wong, Maika Takahashi, Akiko Sugahara-Tobinai, Karin Ono, Shotaro Miyamoto, Keiichi Murakami, Ari Itoh-Nakadai, Dai Kezuka …

International immunology, 33(8) 447-458, Jul 23, 2021
Suppressed humoral immunity is associated with dengue nonstructural protein NS1-elicited anti-death receptor antibody fractions in mice.

Chung-Lin Tsai, Der-Shan Sun, Mei-Tzu Su, Te-Sheng Lien, Yen-Hsu Chen, Chun-Yu Lin, Chung-Hao Huang, Chwan-Chuen King, Chen-Ru Li, Tai-Hung Chen …

Scientific reports, 10(1) 6294-6294, Apr 14, 2020
The Novel Nuclear Targeting and BFRF1-Interacting Domains of BFLF2 Are Essential for Efficient Epstein-Barr Virus Virion Release.

Yu-Ching Dai, Yen-Tzu Liao, Yi-Ting Juan, Yi-Ying Cheng, Mei-Tzu Su, Yu-Zhen Su, Hung-Chun Liu, Ching-Hwa Tsai, Chung-Pei Lee, Mei-Ru Chen

Journal of virology, 94(3), Jan 17, 2020
Gp49B is a pathogenic marker for auto-antibody-producing plasma cells in lupus-prone BXSB/Yaa mice.

Yi Li Wong, Mei-Tzu Su, Akiko Sugahara-Tobinai, So Itoi, Dai Kezuka, Shota Endo, Masanori Inui, Toshiyuki Takai

International immunology, 31(6) 397-406, May 21, 2019
Suppressive effect of dengue virus envelope protein domain III on megakaryopoiesis.

Guan-Ling Lin, Hsin-Hou Chang, Te-Sheng Lien, Po-Kong Chen, Hao Chan, Mei-Tzu Su, Chi-Yuan Liao, Der-Shan Sun

Virulence, 8(8) 1719-1731, Nov 17, 2017 Peer-reviewed
The SWI/SNF Chromatin Regulator BRG1 Modulates the Transcriptional Regulatory Activity of the Epstein-Barr Virus DNA Polymerase Processivity Factor BMRF1.

Mei-Tzu Su, Ya-Ting Wang, Yen-Ju Chen, Su-Fang Lin, Ching-Hwa Tsai, Mei-Ru Chen

Journal of virology, 91(9), May 1, 2017 Peer-reviewed
BGLF4 kinase modulates the structure and transport preference of the nuclear pore complex to facilitate nuclear import of Epstein-Barr virus lytic proteins.

Chou-Wei Chang, Chung-Pei Lee, Mei-Tzu Su, Ching-Hwa Tsai, Mei-Ru Chen

Journal of virology, 89(3) 1703-18, Feb, 2015 Peer-reviewed
Uracil DNA glycosylase BKRF3 contributes to Epstein-Barr virus DNA replication through physical interactions with proteins in viral DNA replication complex.

Mei-Tzu Su, I-Hua Liu, Chia-Wei Wu, Shu-Ming Chang, Ching-Hwa Tsai, Pei-Wen Yang, Yu-Chia Chuang, Chung-Pei Lee, Mei-Ru Chen

Journal of virology, 88(16) 8883-99, Aug, 2014 Peer-reviewed
The ESCRT machinery is recruited by the viral BFRF1 protein to the nucleus-associated membrane for the maturation of Epstein-Barr Virus.

Chung-Pei Lee, Po-Ting Liu, Hsiu-Ni Kung, Mei-Tzu Su, Huey-Huey Chua, Yu-Hsin Chang, Chou-Wei Chang, Ching-Hwa Tsai, Fu-Tong Liu, Mei-Ru Chen

PLoS pathogens, 8(9) e1002904, Sep, 2012 Peer-reviewed
Epstein-Barr virus BGLF4 kinase retards cellular S-phase progression and induces chromosomal abnormality.

Yu-Hsin Chang, Chung-Pei Lee, Mei-Tzu Su, Jiin-Tarng Wang, Jen-Yang Chen, Su-Fang Lin, Ching-Hwa Tsai, Min-Jei Hsieh, Kenzo Takada, Mei-Ru Chen

PloS one, 7(6) e39217, 2012 Peer-reviewed
Hypertonic saline enhances host defense and reduces apoptosis in burn mice by increasing toll-like receptors.

Lee-Wei Chen, Mei-Tzu Su, Pei-Hsuan Chen, Wen-Chung Liu, Ching-Mei Hsu

Shock (Augusta, Ga.), 35(1) 59-66, Jan, 2011 Peer-reviewed
Triple genetic identities for the complete hydatidiform mole, placenta and co-existing fetus after transfer of a single in vitro fertilized oocyte: case report and possible mechanisms.

Chao-Chin Hsu, I-Wen Lee, Mei-Tzu Su, Yi-Chien Lin, Christine Hsieh, Pei-Yi Chen, Hung-Wen Tsai, Pao-Lin Kuo

Human reproduction (Oxford, England), 23(12) 2686-91, Dec, 2008

Misc.

Fcγレセプター，抑制性レセプター

遠藤章太, 蘇美慈, 高井俊行

臨床免疫・アレルギー科, 73(1) 43-50, Jan, 2020 Peer-reviewedInvited
Immune regulation by PirB/LILRB2 and gp49B/LILRB4

Endo S, Su MT, Takai T

Seitai no Kagaku, 70(3) 223-229, Jun, 2019 Peer-reviewedInvited

Research Projects

A novel mechanism of fibronectin/LILRB4 immune checkpoint in the regulation of the tumor microenvironment

科学研究費助成事業, 若手研究, 日本学術振興会, Apr, 2022 - Mar, 2025

蘇美慈
The role of LILRB4 on MDSC-mediated immunosuppression in tumor environment

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

SU Mei-Tzu

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