Davide Cossu

Profile Information

Affiliation: neurology, Juntendo University

Degree: PhD

J-GLOBAL ID: 201801000821761407
researchmap Member ID: B000299379

My research focuses on the role of host-pathogen interactions in the initiation and perpetuation of immune-mediated diseases, on the gut-brain axis interactions, and on the impact of mitochondrial dysfunction on neuroinflammation and neurodegeneration.

Research Interests

Research Areas

Life sciences / Immunology / neuroimmunology, microbiology

Education

Nov, 2012 - Feb, 2016

Doctoral School in Microbiology & Immunology, Biomedical Sciences, Sassari University (Italy)
May, 2012 - Feb, 2013

Secondary Level Master in Bioinformatics, Bioinformatics, Cagliari University (Italy)
Jan, 2006 - Sep, 2007

Secondary Level Master in Microbiology, Institut Universitari de Ciéncia i Tecnologia (IUCT) (Spain)
Nov, 1999 - Apr, 2005

Master of Science (MSc) in Biology, Cagliari University (Italy)
Sep, 2002 - Aug, 2003

Visiting student, Oviedo University (Spain)

Papers

The glymphatic system as a potential biomarker and therapeutic target in secondary progressive multiple sclerosis.

Yuji Tomizawa, Akifumi Hagiwara, Yasunobu Hoshino, Moto Nakaya, Koji Kamagata, Davide Cossu, Kazumasa Yokoyama, Shigeki Aoki, Nobutaka Hattori

Multiple sclerosis and related disorders, 83 105437-105437, Jan 8, 2024
Epstein–Barr Virus and Human Endogenous Retrovirus in Japanese Patients with Autoimmune Demyelinating Disorders

Davide Cossu, Yuji Tomizawa, Leonardo Antonio Sechi, Nobutaka Hattori

International Journal of Molecular Sciences, 24(24) 17151-17151, Dec 5, 2023 Peer-reviewedLead authorCorresponding author
The Role of Immune Dysfunction in Parkinson’s Disease Development

Davide Cossu, Taku Hatano, Nobutaka Hattori

International Journal of Molecular Sciences, 24(23) 16766-16766, Nov 26, 2023 Peer-reviewedLead authorCorresponding author
Correlation between antibodies against the pathogenic <scp>pHERV‐W</scp> envelope protein and the inflammatory phase of multiple sclerosis

Stefano Ruberto, Davide Cossu, Leonardo A. Sechi

Immunology, Nov 20, 2023 Peer-reviewed
Association of HLA-A*11:01, -A*24:02, and -B*18:01 with Prostate Cancer Risk: A Case-Control Study

Maria Antonietta Manca, Elena Rita Simula, Davide Cossu, Tatiana Solinas, Massimo Madonia, Roberto Cusano, Leonardo Antonio Sechi

International Journal of Molecular Sciences, 24(20) 15398-15398, Oct 20, 2023 Peer-reviewed
Influence of aging, mitochondrial dysfunction, and inflammation on Parkinson’s disease

Davide Cossu, Nobutaka Hattori

Neural Regeneration Research, 19(6) 1197-1198, Sep 22, 2023 Peer-reviewedLead authorCorresponding author
Mycobacterium avium subsp. paratuberculosis Antigens Elicit a Strong IgG4 Response in Patients with Multiple Sclerosis and Exacerbate Experimental Autoimmune Encephalomyelitis

Davide Cossu, Yuji Tomizawa, Kazumasa Yokoyama, Tamami Sakanishi, Eiichi Momotani, Leonardo A. Sechi, Nobutaka Hattori

Life, 13(7) 1437-1437, Jun 25, 2023 Peer-reviewedLead authorCorresponding author
Adjuvant Activity of <em>Mycobacterium paratuberculosis</em> in Enhancing the Immunogenicity of Autoantigens During Experimental Autoimmune Encephalomyelitis

Davide Cossu, Yuji Tomizawa, Eiichi Momotani, Kazumasa Yokoyama, Nobutaka Hattori

Journal of Visualized Experiments, (195), May 12, 2023
A Multigene-Panel Study Identifies Single Nucleotide Polymorphisms Associated with Prostate Cancer Risk

Maria Antonietta Manca, Fabio Scarpa, Davide Cossu, Elena Rita Simula, Daria Sanna, Stefano Ruberto, Marta Noli, Hajra Ashraf, Tatiana Solinas, Massimo Madonia …

International Journal of Molecular Sciences, 24(8) 7594-7594, Apr 20, 2023
Bacillus Calmette–Guérin Tokyo-172 vaccine provides age-related neuroprotection in actively induced and spontaneous experimental autoimmune encephalomyelitis models

Davide Cossu, Kazumasa Yokoyama, Tamami Sakanishi, Leonardo A Sechi, Nobutaka Hattori

Clinical and Experimental Immunology, 212(1) 70-80, Feb 6, 2023
Latent Potential of Multifunctional Selenium Nanoparticles in Neurological Diseases and Altered Gut Microbiota.

Hajra Ashraf, Davide Cossu, Stefano Ruberto, Marta Noli, Seyedesomaye Jasemi, Elena Rita Simula, Leonardo A Sechi

Materials (Basel, Switzerland), 16(2), Jan 11, 2023
Comparing clinical and imaging features of patients with MOG antibody-positivity and with and without oligoclonal bands.

Yuji Tomizawa, Yasunobu Hoshino, Ryota Kamo, Davide Cossu, Kazumasa Yokoyama, Nobutaka Hattori

Frontiers in immunology, 14 1211776-1211776, 2023
HERV-K Envelope Protein Induces Long-Lasting Production of Autoantibodies in T1DM Patients at Onset in Comparison to ZNT8 Autoantibodies.

Marta Noli, Gianfranco Meloni, Stefano Ruberto, Seyedesomaye Jasemi, Elena Rita Simula, Davide Cossu, Marco Bo, Mario Palermo, Leonardo A Sechi

Pathogens (Basel, Switzerland), 11(10), Oct 15, 2022
Autoantibodies against Proinsulin, Human Endogenous Retrovirus W (HERV-W) and Mycobacterium avium Subspecies Paratuberculosis (MAP) Slowly Decrease Years after T1DM Diagnosis

Marta Noli, Gianfranco Meloni, Elena Rita Simula, Maria Antonietta Manca, Seyedesomaye Jasemi, Stefano Ruberto, Davide Cossu, Mario Palermo, Leonardo A. Sechi

Zoonotic Diseases, 2(1) 37-43, Mar, 2022 Peer-reviewed
Age related immune modulation of experimental autoimmune encephalomyelitis in PINK1 knockout mice.

Davide Cossu, Kazumasa Yokoyama, Shigeto Sato, Sachiko Noda, Tamami Sakanishi, Leonardo Antonio Sechi, Nobutaka Hattori

Frontiers in immunology, 13 1036680-1036680, 2022
Efficacy of BCG vaccine in animal models of neurological disorders

Cossu D, Ruberto S, Yokoyama K, Hattori N, Sechi LA

Vaccine, 40(3) 432-436, Jan, 2022 Peer-reviewedLead authorCorresponding author
Editorial: A Microbial View of Central Nervous System Disorders: Interplay Between Microorganisms, Neuroinflammation and Behaviou

Cossu D, Watson RO, Farina C

Frontiers in Immunology, 12(816227), Dec, 2021 Peer-reviewedLead author
Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis.

Fumie Hayashi, Noriko Isobe, Davide Cossu, Kazumasa Yokoyama, Ayako Sakoda, Takuya Matsushita, Nobutaka Hattori, Jun-Ichi Kira

Journal of neuroimmunology, 360 577701-577701, Nov 15, 2021 Peer-reviewed
PARKIN modifies peripheral immune response and increases neuroinflammation in active experimental autoimmune encephalomyelitis (EAE).

Davide Cossu, Kazumasa Yokoyama, Shigeto Sato, Sachiko Noda, Leonardo A Sechi, Nobutaka Hattori

Journal of neuroimmunology, 359 577694-577694, Oct 15, 2021 Peer-reviewedLead author
多発性硬化症患者におけるmycobacterium avium subsp.paratuberculosis抗体の上昇

林史恵, Cossu Davide, 横山和正, 迫田礼子, 松下拓也, 服部信孝, 吉良潤一, 磯部紀子

神経免疫学, 26(1) 121-121, Oct, 2021

Misc.

MS/NMO 多発性硬化症・視神経脊髄炎患者の末梢血におけるリンパ球の解析

星野泰延, 能登大介, 横山和正, コッス・ダビデ, 服部信孝, 三宅幸子

神経免疫学, 23(1) 94-94, Sep, 2018
Comparison of humoral immunity against acid-fast bacilli lipophilic antigens in patients with Japanese MS and NMOSD

K. Yokoyama, D. Cossu, N. Hattori

MULTIPLE SCLEROSIS JOURNAL, 23 212-212, Oct, 2017
MS・NMO2 多発性硬化症・視神経脊髄炎患者の末梢血における骨髄系細胞の解析

星野泰延, 能登大介, 横山和正, コッス・ダビデ, 服部信孝, 三宅幸子

神経免疫学, 22(1) 115-115, Oct, 2017
IDENTIFICATION OF HERV-K ENV SURFACE PEPTIDES HIGHLY RECOGNIZED IN RA PATIENTS

G. L. Erre, G. Mameli, D. Cossu, S. Mura, A. Piras, M. L. Cadoni, G. Buscetta, N. Mundula, E. Colombo, M. G. Longu …

ANNALS OF THE RHEUMATIC DISEASES, 76 496-496, Jun, 2017
EBV and Mycobacterium avium subsp. paratuberculosis peptides induce a diffuse immune response against myelin basic protein and human interferon regulatory factor 5 in MS patients

J. Frau, G. Mameli, D. Cossu, G. Arru, E. Caggiu, G. Coghe, L. Lorefice, G. Fenu, M. A. Secci, M. C. Melis …

MULTIPLE SCLEROSIS JOURNAL, 21 676-676, Sep, 2015
食物アレルギーの研究と微生物の関連を考える食品を汚染する微生物に起因するアレルギー(Microbiological Research Contributes to Food Allergy Allergy induced by microorganisms contaminated in foods)

百溪英一, Cossu Davide, 大坪茂, 山本静雄, 栗林尚志, 江田栄俊

日本細菌学雑誌, 70(1) 92-92, Feb, 2015
Mycobacterium avium subsp Paratuberculosis and multiple sclerosis in Sardinian patients

E. Cocco, J. Frau, D. Cossu, G. Coghe, L. Lorefice, G. Fenu, M. Melis, M. R. Murru, C. Sardu, L. Sechi …

MULTIPLE SCLEROSIS JOURNAL, 18 369-369, Oct, 2012
Antibodies directed against mycobacterium avium paratuberculosis show a crossed reactivity with antigene beta-cellular ZnT8 in Sardinian type 1 diabetic patients

S. Masala, D. Paccagnini, D. Cossu, V. Brezar, A. Pacifico, N. Ahmed, L. Sechi, R. Mallone

DIABETES & METABOLISM, 38 A4-A4, Mar, 2012

Professional Memberships

Jun, 2022 - Present

The Japanese Society of Neuroimmunology
Jun, 2022 - Present

Italian Society of Microbiology
JAPANESE SOCIETY OF NEUROLOGY
ITALIAN NATIONAL SOCIETY OF BIOLOGIST

Research Projects

Interplay between mitophagy and pathogens in neuroinflammation

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2023 - Mar, 2026

COSSU DAVIDE
Functional analysis of astrocytes by using experimental autoimmune encephalomyelitis animal model (EAE)

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2020 - Mar, 2023

COSSU DAVIDE
international comparison of environment and genetic risk factors in MS

Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows, Grant-in-Aid for JSPS Fellows, Japan Society for the Promotion of Science, Nov, 2016 - Mar, 2018
Role of Mycobacterium avium paratuberculosis antigen in the host immune modification and pathogenesis of IBD

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2016

Momotani Eiichi, KURIBAYASHI Tadashi, Yamamoto Shizuo, Cossu Davide