Takahiro Muraoka

Profile Information

Affiliation: Tokyo University of Agriculture and Technology
: (Concurrent)Institute of Engineering

Degree: Ph. D.(Mar, 2007, The University of Tokyo)

J-GLOBAL ID: 201601020628903659
researchmap Member ID: B000256145

External link: https://www.muraoka-lab.com/blank-1

Research Interests

Research Areas

Nanotechnology/Materials / Biochemistry / Bio-related chemistry

Research History

Oct, 2013 - Mar, 2017

PRESTO Researcher, PRESTO(Precursory Research for Embryonic Science and Technology), Japan Science and Technology Agency
May, 2015 - Jan, 2017

Assistant Professor, School of Life Science and Technology, Tokyo Institute of Technology
May, 2008 - Apr, 2015

Assistant Professor, Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
Apr, 2007 - Apr, 2008

JSPS Researcher (Research Fellowship for Young Scientists), The Japan Society for the Promotion of Science
Jul, 2006 - Apr, 2008

Visiting Scholar, Department of Chemistry, Northwestern University
Apr, 2004 - Mar, 2007

JSPS Researcher (Young Scientists Fellowship), The Japan Society for the Promotion of Science

Education

Apr, 2004 - Mar, 2007

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Apr, 2002 - Mar, 2004

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Apr, 1998 - Mar, 2002

Faculty of Chemistry and Biotechnology, School of Engineering, The University of Tokyo

Awards

Sep, 2019

マツダ研究助成奨励賞, 選択的分子捕捉材料の開発と応用, マツダ財団

村岡貴博
Oct, 2018

公益信託第21回エスペック地球環境研究奨励賞, エスペック

村岡貴博
Oct, 2018

学長賞, 東京農工大学
Jun, 2018

一般財団法人天野エンザイム科学技術振興財団第19回酵素応用シンポジウム研究奨励賞, 天野エンザイム科学技術振興財団

村岡貴博
Aug, 2016

平成28年度東京工業大学挑戦的研究賞, 東京工業大学

村岡貴博
Jun, 2016

Japan–Taiwan Joint Seminar on Energy and Environment for Young Chemists Poster Award, Taiwan, Japan–Taiwan Joint Seminar on Energy and Environment for Young Chemists

鍋谷光太, 村岡貴博, 金原数
Apr, 2016

平成28年度科学技術分野の文部科学大臣表彰若手科学者賞, 生体から着想した刺激応答性機能性分子開発に関する研究, 文部科学省

村岡貴博
Mar, 2015

日本化学会進歩賞, 生体模倣から着想した刺激応答性機能性分子の開発, 日本化学会

村岡貴博
Sep, 2014

第8回バイオ関連化学シンポジウム講演賞, PEGの構造修飾によるタンパク質関連機能の展開, 日本化学会

村岡貴博
Apr, 2014

日本化学会第94春季年会優秀講演賞（学術）, 外部刺激応答性膜挿入分子の開発, 日本化学会

村岡貴博
Dec, 2013

「籏野奨学基金」第8回多元物質科学研究奨励賞, 生体から学び、生体への応用を指向した水中での超分子化学の展開, 東北大学多元物質科学研究所

村岡貴博
Oct, 2013

積水化学「自然に学ぶものづくり」研究助成プログラム奨励賞, タンパク質同様の熱応答性を示す水溶性機能分子の開発とタンパク質安定化への応用, 積水化学

村岡貴博
Mar, 2010

日本化学会若い世代の特別講演証, 光反応をトリガーとする分子内・分子間での動きの変換と伝達, 日本化学会

村岡貴博
Feb, 2009

井上研究奨励賞, 井上科学振興財団

村岡貴博
Mar, 2007

東京大学大学院工学系研究科長賞, 連動可能な可動部位から成る分子機械の設計, 東京大学

村岡貴博
Mar, 2006

日本化学会第86春季年会学生講演賞, 光駆動分子機械を用いた超分子的な動きの伝達, 日本化学会

村岡貴博

Papers

ROS‐Triggered Gel‐Sol Transition and Kinetics‐Controlled Cargo Release by Methionine‐Containing Peptides

Yoshika Hara, Atsuya Yaguchi, Hirotsugu Hiramatsu, Takahiro Muraoka

ChemBioChem, 24(9), May 2, 2023
Amphiphilic peptide-tagged N-cadherin forms radial glial-like fibers that enhance neuronal migration in injured brain and promote sensorimotor recovery.

Yuya Ohno, Chikako Nakajima, Itsuki Ajioka, Takahiro Muraoka, Atsuya Yaguchi, Teppei Fujioka, Saori Akimoto, Misaki Matsuo, Ahmed Lotfy, Sayuri Nakamura …

Biomaterials, 294 122003-122003, Mar, 2023
Endocytosis-Like Vesicle Fission Mediated by a Membrane-Expanding Molecular Machine Enables Virus Encapsulation for In Vivo Delivery

Noriyuki Uchida, Yunosuke Ryu, Yuichiro Takagi, Ken Yoshizawa, Kotono Suzuki, Yasutaka Anraku, Itsuki Ajioka, Naofumi Shimokawa, Masahiro Takagi, Norihisa Hoshino …

Journal of the American Chemical Society, 145(11) 6210-6220, Feb 28, 2023
Amphiphilic structured PEG derivatives suppressing protein thermal aggregation at extremely low molecular ratio

Adam Wawro, Takahiro Muraoka, Wijak Yospanya, Mayu Kawame, Yudai Nakagawa, Mihoko Ui, Pawel Antonik, Peter Crowley, Kouhei Tsumoto, Kazushi Kinbara

Feb 9, 2023
Semi-enzymatic acceleration of oxidative protein folding by N-methylated heteroaromatic thiols

Shunsuke Okada, Yosuke Matsumoto, Rikana Takahashi, Kenta Arai, Shingo Kanemura, Masaki Okumura, Takahiro Muraoka

Chemical Science, 2023
Cell-Penetrating Peptide-Peptide Nucleic Acid Conjugates as a Tool for Protein Functional Elucidation in the Native Bacterium.

Yasuhito Yokoi, Yugo Kawabuchi, Abdullah Adham Zulmajdi, Reiji Tanaka, Toshiyuki Shibata, Takahiro Muraoka, Tetsushi Mori

Molecules (Basel, Switzerland), 27(24), Dec 15, 2022
Self-assembling Molecular Medicine for the Subacute Phase of Ischemic Stroke.

Takahiro Muraoka, Itsuki Ajioka

Neurochemical research, 47(9) 2488-2498, Sep, 2022 Peer-reviewed
Stabilization of bicelles using metal-binding peptide for extended blood circulation

Yuichiro Takagi, Noriyuki Uchida, Yasutaka Anraku, Takahiro Muraoka

CHEMICAL COMMUNICATIONS, 58(33) 5164-5167, Apr, 2022
Biophysical elucidation of neural network and chemical regeneration of neural tissue

Takahiro Muraoka, Tomohide Saio, Masaki Okumura

Biophysics and Physicobiology, 2022
Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration.

Atsuya Yaguchi, Mio Oshikawa, Go Watanabe, Hirotsugu Hiramatsu, Noriyuki Uchida, Chikako Hara, Naoko Kaneko, Kazunobu Sawamoto, Takahiro Muraoka, Itsuki Ajioka

Nature communications, 12(1) 6623-6623, Nov 19, 2021
Supramolecular Transmembrane Ion Channels Formed by Multiblock Amphiphiles

Kohei Sato, Takahiro Muraoka, Kazushi Kinbara

Accounts of Chemical Research, Oct 5, 2021 Peer-reviewed
Critical Side Chain Effects of Cell-Penetrating Peptides for Transporting Oligo Peptide Nucleic Acids in Bacteria.

Go Inoue, Daichi Toyohara, Tetsushi Mori, Takahiro Muraoka

ACS applied bio materials, 4(4) 3462-3468, Apr 19, 2021
Hydrogel-Stiffening and Non-Cell Adhesive Properties of Amphiphilic Peptides with Central Alkylene Chains.

Atsuya Yaguchi, Hirotsugu Hiramatsu, Atsuya Ishida, Mio Oshikawa, Itsuki Ajioka, Takahiro Muraoka

Chemistry (Weinheim an der Bergstrasse, Germany), Apr 19, 2021
Conjugate of Thiol and Guanidyl Units with Oligoethylene Glycol Linkage for Manipulation of Oxidative Protein Folding

Shunsuke Okada, Motonori Matsusaki, Masaki Okumura, Takahiro Muraoka

Molecules, 26(4) 879-879, Feb 7, 2021
Self-assembly of Amphiphilic Peptide in Phospholipid Membrane

Anju Kawakita, Noriyuki Uchida, Yunosuke Ryu, Takahiro Muraoka

JOURNAL OF PHOTOPOLYMER SCIENCE AND TECHNOLOGY, 34(2) 155-159, 2021
Current Progress in Cross-Linked Peptide Self-Assemblies

Noriyuki Uchida, Takahiro Muraoka

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(20), Oct, 2020
A synthetic ion channel with anisotropic ligand response.

Takahiro Muraoka, Daiki Noguchi, Rinshi S Kasai, Kohei Sato, Ryo Sasaki, Kazuhito V Tabata, Toru Ekimoto, Mitsunori Ikeguchi, Kiyoto Kamagata, Norihisa Hoshino …

Nature communications, 11(1) 2924-2924, Jun 10, 2020 Peer-reviewed
New Modified Deoxythymine with Dibranched Tetraethylene Glycol Stabilizes G-Quadruplex Structures.

Hisae Tateishi-Karimata, Tatsuya Ohyama, Takahiro Muraoka, Shigenori Tanaka, Kazushi Kinbara, Naoki Sugimoto

Molecules (Basel, Switzerland), 25(3), Feb 6, 2020 Peer-reviewed
Thermo-driven self-assembly of a PEG-containing amphiphile in a bilayer membrane

Rui Li, Takahiro Muraoka, Kazushi Kinbara

RSC Advances, 2020
Reversible formation of multiple stimuli-responsive polymeric materials through processing control of trifunctional amphiphilic molecules

Takahiro Muraoka, Hidetaka Honda, Kota Nabeya, Kazushi Kinbara

Chemical Communications, 2020

Misc.

Promotion effects of aromatic compounds on oxidative protein folding

松本陽佑, 松崎元紀, 稲葉謙次, 奥村正樹, 村岡貴博, 村岡貴博

日本化学会春季年会講演予稿集(Web), 102nd, 2022
Structural Effects of Reducing Agents on Acceleration of Oxidative Protein Folding

岡田隼輔, 松崎元紀, 稲葉謙次, 奥村正樹, 村岡貴博

日本化学会春季年会講演予稿集(Web), 101st, 2021
Substituent effects of redox-active compounds for promotion of oxidative protein folding

松本陽佑, 松崎元紀, 稲葉謙次, 奥村正樹, 村岡貴博

日本化学会春季年会講演予稿集(Web), 101st, 2021
Development of Novel Thiol-Based Protein Folding Promotors

岡田隼輔, 松崎元紀, 稲葉謙次, 奥村正樹, 村岡貴博

日本化学会春季年会講演予稿集(CD-ROM), 100th, 2020
PEG化タンパク質精製法の確立に向けた新規構造化PEG分子の設計と機能解析

山田千聖, WAWRO Adam, WAWRO Adam, 黒木喜美子, 高橋愛実, 村岡貴博, 村岡貴博, 金原数, 金原数, 前仲勝実

日本生化学会大会(Web), 2017年度 [3P-0167], Dec, 2017
テトラエチレングリコール修飾核酸を活用した新しい逆転写制御法の開発

建石寿枝, 大山達也, 村岡貴博, PODBEVSEK Peter, WAWRO Adam M, 田中成典, 金原数, PLAVEC Janez, 杉本直己, 杉本直己

日本核酸医薬学会年会講演要旨集, 3rd 67, Jul 1, 2017
テトラエチレングリコール修飾塩基をもつ四重鎖構造を用いた逆転写反応制御

建石寿枝, 大山達也, 村岡貴博, PODBEVSEK Peter, 田中成典, 金原数, PLAVEC Janez, 杉本直己, 杉本直己

日本核酸医薬学会年会講演要旨集, 2nd 93, Nov 1, 2016
Cover Picture: G-Quadruplexes with Tetra(ethylene glycol)-Modified Deoxythymidines are Resistant to Nucleases and Inhibit HIV-1 Reverse Transcriptase (ChemBioChem 15/2016)

Hisae Tateishi-Karimata, Takahiro Muraoka, Kazushi Kinbara, Naoki Sugimoto

ChemBioChem, 17(15) 1385, Aug 3, 2016
テトラエチレングリコール修飾によるDNA四重鎖の安定化機構の解明

大山達也, 建石寿枝, 田中成典, 村岡貴博, 金原数, 杉本直己, 杉本直己

分子科学討論会講演プログラム&要旨(Web), 10th, 2016
PEG化タンパク質の精製に向けた新規PEG化試薬の設計

山田千聖, Wawro Adam, 黒木喜美子, 高橋愛実, 村岡貴博, 金原数, 前仲勝実

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [2P0459]-[2P0459], Dec, 2015
Enhancement of Protein Thermostability by Structured PEG

89(1) 9-14, Jan, 2015
7pAQ-3 Molecular phase separation in a cell-sized vesicle

Ishii Takero, Kawasaki Shunichi, Muraoka Takahiro, Kinbara Kazushi, Nagai Ken H., Hamada Tsutomu

Meeting abstracts of the Physical Society of Japan, 69(2) 195-195, Aug 22, 2014
A Structured Monodisperse PEG for the Effective Suppression of Protein Aggregation

Takahiro Muraoka, Kota Adachi, Mihoko Ui, Shunichi Kawasaki, Nabanita Sadhukhan, Haruki Obara, Hidehito Tochio, Masahiro Shirakawa, Kazushi Kinbara

Angewandte Chemie International Edition, 52(9) 2430-2434, 2013
Development and Functionalization of Structural Mimics of Multipass Transmembrane Proteins

Takahiro Muraoka, Kazushi Kinbara

有機合成化学協会誌, 71(10) 1045-1050, 2013
Development of photoresponsive supramolecular machines inspired by biological molecular systems

Takahiro Muraoka, Kazushi Kinbara

Journal of Photochemistry and Photobiology C: Photochemistry Reviews, 13(2) 136-147, 2012
Ion permeation by a folded multiblock amphiphilic oligomer achieved by hierarchical construction of self-assembled nanopores.

Takahiro Muraoka, Tatsuya Shima, Tsutomu Hamada, Masamune Morita, Masahiro Takagi, Kazuhito V Tabata, Hiroyuki Noji, Kazushi Kinbara

Journal of the American Chemical Society, 134(48) 19788-19794, 2012
Mimicking Multipass Transmembrane Proteins: Synthesis, Assembly and Folding of Alternating Amphiphilic Multiblock Molecules in Liposomal Membranes

Takahiro Muraoka, Tatsuya Shima, Tsutomu Hamada, Masamune Morita, Masahiro Takagi, Kazushi Kinbara

Chemical Communications, 47(1) 194-196, 2011
AEI 80-Experimental peptide assembly and application

Honggang Cui, Eugene Tommy Pashuck, Takahiro Muraoka, Andrew Cheetham, Samuel I. Stupp

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 236, Aug, 2008
Chiral Ferrocenes as Novel Rotary Modules for Molecular Machines

Kazushi Kinbara, Takahiro Muraoka, Takuzo Aida

Org. Biomol. Chem., 1871-1876, 2008
Reversible Operation of Chiral Molecular Scissors by Redox and UV Light

Takahiro Muraoka, Kazushi Kinbara, Takuzo Aida

Chemical Communications, 1441-1443, 2007

Books and Other Publications

Molecular Technology for Membrane Functionalization in Molecular Technology, Volume 2: Life Innovation

Michio Murakoshi, Takahiro Muraoka

Wiley, Dec 10, 2018

Presentations

Macroscopic Membrane Deformation by Stimuli-responsive Functional Molecules

Takahiro Muraoka

pi-EJ 2019, Nov 13, 2019 Invited
Development of Membrane Penetrating Substances for Bacteria

Go Inoue, Daichi Toyohara, Tetsushi Mori, Takahiro Muraoka

pi-EJ 2019, Nov 13, 2019
Morphological Changes of Self-assembled Structures by Single-Bond Rotating Motion

Yunosuke Ryu, Naofumi Shimokawa, Masahiro Takagi, Takahiro Muraoka

pi-EJ 2019, Nov 13, 2019
All-atom molecular dynamics simulations of artificial ion channels

Takahiro Osamura, Toru Ekimoto, Tsutomu Yamane, Takahiro Muraoka, Kazushi Kinbara, Mitsunori Ikeguchi

情報計算化学生物学会（CBI学会2019年大会）, Oct 22, 2019
Development of Membrane Penetrating Substances for Microbes

Go Inoue, Daichi Toyohara, Tetsushi Mori, Takahiro Muraoka

CSJ化学フェスタ, Oct 16, 2019
Redoxで発動するタンパク質フォールディング

村岡貴博

高分子討論会, Sep 26, 2019, 高分子学会 Invited
All-atom molecular dynamics simulations of artificial ion channels

長村隆大, 浴本亨, 山根努, 村岡貴博, 金原数, 池口満徳

生物物理学会, Sep 24, 2019
Acceleration of oxidative protein folding by newly-developed redox molecules

松崎元紀, 岡田隼輔, 荒井堅太, 日高雄二, 稲葉謙次, 村岡貴博, 奥村正樹

第92回日本生化学会大会, Sep 18, 2019
分子の動きから発想するバイオ材料化学

村岡貴博

東京大学工学部応用化学科野地研究室セミナー, Sep 18, 2019 Invited
微生物膜透過性を有するペプチドの探索と評価

村岡貴博, 井上豪, 豊原大智, モリテツシ

日本微生物生態学会, Sep 12, 2019
Identification of factors hindering cell-penetrating peptide permeabilization

Yuki Shibuya, Daichi Toyohara, Yunosuke Ryu, Takahiro Muraoka, Tetsushi Mori

Marine Biotechnology Conference 2019, Sep 9, 2019
Cell-penetrating-peptides potentially enhances biomolecule delivery in bacteria

Daichi Toyohara, Yasuhito Yokoi, Go Inoue, Takahiro Muraoka, Tetsushi Mori

Marine Biotechnology Conference 2019, Sep 9, 2019
Synthetic Promotors of Oxidative Protein Folding

Takahiro Muraoka

10th RSC-CSJ Joint Symposium – Chemistry for Complex Biological Systems –, Sep 7, 2019
Development of Membrane Penetrating Substances for Microbes

Go Inoue, Daichi Toyohara, Tetsushi Mori, Takahiro Muraoka

バイオ関連化学シンポジウム, Sep 5, 2019
ウレア基を付与したチオールによる酸化的タンパク質フォールディングの促進

村岡貴博, 岡田隼輔, 松崎元紀, 荒井堅太, 日高雄二, 稲葉謙次, 奥村正樹

バイオ関連化学シンポジウム, Sep 4, 2019
ペプチド集合体の形態と動的特性に与えるグリシン置換の効果

石田敦也, 味岡逸樹, 渡辺豪, 村岡貴博

バイオ関連化学シンポジウム, Sep 4, 2019
Development of Redox Molecules Accelerating Oxidative Protein Folding

Shunsuke Okada, Motonori Matsusaki, Kenta Arai, Yuji Hidaka, Kenji Inaba, Masaki Okumura, Takahiro Muraoka

バイオ関連化学シンポジウム, Sep 4, 2019
Morphological Changes of Self-assembled Structures by Single-bond Rotating Motion

Yunosuke Ryu, Naofumi Shimokawa, Masahiro Takagi, Takahiro Muraoka

バイオ関連化学シンポジウム, Sep 4, 2019
タンパク質を安定化する低分子の新設計

村岡貴博

有機合成化学協会関東支部ミニシンポジウムー湘南2019ー, Jul 6, 2019, 有機合成化学協会関東支部 Invited
Protein Folding Acceleration by Redox-Active Molecules

Takahiro Muraoka

東京大学工学系研究科化学生命工学専攻講演会「化学と生命のかけはし」, Jul 5, 2019, 東京大学工学系研究科化学生命工学専攻 Invited

Professional Memberships

Research Projects

Development of kinetics-controlling molecules for construction of asymmetric structures

Grants-in-Aid for Scientific Research, Grant-in-Aid for Transformative Research Areas (B), Japan Society for the Promotion of Science, Aug, 2021 - Mar, 2024
Organization of kinetics-driven supramolecular chemistry

Grants-in-Aid for Scientific Research, Grant-in-Aid for Transformative Research Areas (B), Japan Society for the Promotion of Science, Aug, 2021 - Mar, 2024
Kinetics-Driven Supramolecular Chemistry

Grants-in-Aid for Scientific Research, Grant-in-Aid for Transformative Research Areas (B), Japan Society for the Promotion of Science, Aug, 2021 - Mar, 2024
光トランスフェクション法の開発

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jul, 2021 - Mar, 2024

村岡貴博
Development of a novel biomolecule delivery system for the establishment of high productivity mutant strains

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2021 - Mar, 2023
物質輸送光発動分子システムの構築と応用

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2021 - Mar, 2022

村岡貴博
Biomimetic Development of Oxidative Protein Folding Promotors

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Muraoka Takahiro
動的多次元場を構築する機能性分子開発

若手研究(A), 2017 - 2019
多様な刺激に応答するπ組織体の応用

新学術領域研究（研究領域提案型）, 2017 - 2018
タンパク質疾患治療技術を指向したタンパク質機能を肩代わりする合成分子の開発

commissioned research, 国立研究開発法人科学技術振興機構, Feb, 2017 - Mar, 2017
多様な刺激に応答するπ組織体の構築

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2015 - Mar, 2017

村岡貴博
Development of structured PEGs and applications to protein stabilization

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Muraoka Takahiro
Development of structured PEG for protein manipulation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

MURAOKA Takahiro
Development of Photoresponsive Bioactive Molecules

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2009 - 2010

MURAOKA Takahiro

Industrial Property Rights

Social Activities

タンパク質合成へ基礎技術

日経産業新聞, 6面, May 31, 2019 - May 31, 2019

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Misc.

Books and Other Publications

Presentations

Professional Memberships

Research Projects

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