1995年1月
Effects of Rat Bile-pancreatic Juice on Fe^<2+> Induced Peroxidation of Phospholipids
Bioscience, biotechnology, and biochemistry
- ,
- ,
- ,
- ,
- 巻
- 59
- 号
- 1
- 開始ページ
- 55
- 終了ページ
- 58
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1271/bbb.59.55
- 出版者・発行元
- 社団法人日本農芸化学会
The effects of rat bile-pancreatic juice (BPJ) on Fe^<2+> induced oxidation of soybean phosphatidylcholine (PC) was monitored to investigate the influence of this digestive juice on oxidative damage in the gastrointestinal tract. A large volume of BPJ (50% in the suspension of PC, v/v) suppressed the lipid peroxidation, but a smaller volume had the reverse effect. BPJ could decompose free fatty acid hydroperoxides (FFA-OOH) at a lower concentration (〜0.2mM) completely, although its phospholipase activity liberated FFA-OOH from PC hydroperoxides. Sodium deoxycholate enhanced the Fe^<2+> induced oxidation of PC in a concentration-dependent manner when PC was suspended in the buffer. Boiled BPJ suppressed Fe^<2+> induced and peroxyl radical initiated oxidation of sodium deoxycholate micelles of soybean PC up to 〜50% (v/v). It was strongly suggested that rat BPJ had a biphasic effect on Fe^<2+> induced oxidation of phospholipids depending on the enhancement by bile salts and the inhibition by antioxidant components with radical-scavenging activity and hydroperoxide-decomposing activity.
- リンク情報
- ID情報
-
- DOI : 10.1271/bbb.59.55
- ISSN : 0916-8451
- CiNii Articles ID : 110002677368
- identifiers.cinii_nr_id : 9000004160034