原田睦生 (Mutsuo Harada) - マイポータル

基本情報

所属: 東京大学

研究者番号: 90431642
J-GLOBAL ID: 202001017712242694
researchmap会員ID: R000005010

論文

Low-carbohydrate diets containing plant-derived fat but not animal-derived fat ameliorate heart failure.

Satoshi Bujo, Haruhiro Toko, Kaoru Ito, Satoshi Koyama, Masato Ishizuka, Masahiko Umei, Haruka Yanagisawa-Murakami, Jiaxi Guo, Bowen Zhai, Chunxia Zhao, Risa Kishikawa, Norifumi Takeda, Kensuke Tsushima, Yuichi Ikeda, Eiki Takimoto, Hiroyuki Morita, Mutsuo Harada, Issei Komuro

Scientific reports 13(1) 3987-3987 2023年3月9日
Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury

Pang Yen Liu, Nobuaki Fukuma, Yukio Hiroi, Akiko Kunita, Hiroyuki Tokiwa, Kazutaka Ueda, Taro Kariya, Genri Numata, Yusuke Adachi, Miyu Tajima, Masayuki Toyoda, Yuxin Li, Kensuke Noma, Mutsuo Harada, Haruhiro Toko, Tetsuo Ushiku, Yoshimitsu Kanai, Eiki Takimoto, James K. Liao, Issei Komuro

JACC: Basic to Translational Science 8(1) 55-67 2023年1月
Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction

Shintaro Yamada, Toshiyuki Ko, Satoshi Hatsuse, Seitaro Nomura, Bo Zhang, Zhehao Dai, Shunsuke Inoue, Masayuki Kubota, Kosuke Sawami, Takanobu Yamada, Tatsuro Sassa, Mikako Katagiri, Kanna Fujita, Manami Katoh, Masamichi Ito, Mutsuo Harada, Haruhiro Toko, Norifumi Takeda, Hiroyuki Morita, Hiroyuki Aburatani, Issei Komuro

Nature Cardiovascular Research 1(11) 1072-1083 2022年11月17日
Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis.

Toshiyuki Ko, Seitaro Nomura, Shintaro Yamada, Kanna Fujita, Takanori Fujita, Masahiro Satoh, Chio Oka, Manami Katoh, Masamichi Ito, Mikako Katagiri, Tatsuro Sassa, Bo Zhang, Satoshi Hatsuse, Takanobu Yamada, Mutsuo Harada, Haruhiro Toko, Eisuke Amiya, Masaru Hatano, Osamu Kinoshita, Kan Nawata, Hiroyuki Abe, Tetsuo Ushiku, Minoru Ono, Masashi Ikeuchi, Hiroyuki Morita, Hiroyuki Aburatani, Issei Komuro

Nature communications 13(1) 3275-3275 2022年6月7日
心筋細胞のβアレスチン偏向性受容体CXCR7は心筋梗塞後リモデリングを抑制する

石塚理人, 原田睦生, 野村征太郎, 候聡志, 武城怜史, 郭嘉煕, てき博文, 岸川理紗, 東口治弘, 小室一成

日本内分泌学会雑誌 97(5) 1476-1476 2022年3月
Lipin1, a Regulator of Lipid Homeostasis, Protects Heart against Ischemic Injury(和訳中)

Guo Jiaxi, Toko Haruhiro, Ueda Kazutaka, Ishizuka Masato, Adachi Yusuke, Bujo Satoshi, Otani Akira, Hashimoto Masaki, Kishikawa Risa, Zhai Bowen, Harada Mutsuo, Komuro Issei

日本循環器学会学術集会抄録集 86回 OSYIA-3 2022年3月
心筋細胞のβアレスチン偏向性受容体CXCR7は心筋梗塞後リモデリングを抑制する

石塚理人, 原田睦生, 野村征太郎, 候聡志, 武城怜史, 郭嘉煕, てき博文, 岸川理紗, 東口治弘, 小室一成

日本内分泌学会雑誌 97(5) 1476-1476 2022年3月
Three-Dimensional Visualization of Hypoxia-Induced Pulmonary Vascular Remodeling in Mice.

Takayuki Fujiwara, Norifumi Takeda, Hironori Hara, Satoshi Ishii, Genri Numata, Hiroyuki Tokiwa, Sonoko Maemura, Takaaki Suzuki, Hiroshi Takiguchi, Yoshiaki Kubota, Kinya Seo, Asuka Sakata, Seitaro Nomura, Masaru Hatano, Kazutaka Ueda, Mutsuo Harada, Haruhiro Toko, Eiki Takimoto, Hiroshi Akazawa, Satoshi Nishimura, Issei Komuro

Circulation 144(17) 1452-1455 2021年10月26日
Author Correction: CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor.

Ishizuka M, Harada M, Nomura S, Ko T, Ikeda Y, Guo J, Bujo S, Yanagisawa-Murakami H, Satoh M, Yamada S, Kumagai H, Motozawa Y, Hara H, Fujiwara T, Komuro I

Scientific reports 2021年6月
βアレスチン偏向性受容体CXCR7は心筋梗塞後リモデリングを抑制する

石塚理人, 原田睦生, 野村征太郎, 候聡志, 池田祐一, 熊谷英敏, 武城怜史, 郭嘉煕, てき博文, 東口治弘, 小室一成

血管 44(1) 40-40 2021年6月
CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor.

Masato Ishizuka, Mutsuo Harada, Seitaro Nomura, Toshiyuki Ko, Yuichi Ikeda, Jiaxi Guo, Satoshi Bujo, Haruka Yanagisawa-Murakami, Masahiro Satoh, Shintaro Yamada, Hidetoshi Kumagai, Yoshihiro Motozawa, Hironori Hara, Takayuki Fujiwara, Tatsuyuki Sato, Norifumi Takeda, Norihiko Takeda, Kinya Otsu, Hiroyuki Morita, Haruhiro Toko, Issei Komuro

Scientific reports 11(1) 3426-3426 2021年2月9日
Factors associated with left ventricular reverse remodelling after percutaneous coronary intervention in patients with left ventricular systolic dysfunction.

Yusuke Adachi, Arihiro Kiyosue, Jiro Ando, Takuya Kawahara, Satoshi Kodera, Shun Minatsuki, Hironobu Kikuchi, Toshiro Inaba, Hiroyuki Kiriyama, Kazutoshi Hirose, Hiroki Shinohara, Akihito Saito, Takayuki Fujiwara, Hironori Hara, Kazutaka Ueda, Kenichi Sakakura, Masaru Hatano, Mutsuo Harada, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Shin-Ichi Momomura, Hideo Fujita, Issei Komuro

Scientific reports 11(1) 239-239 2021年1月8日
Omega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart

Haruhiro Toko, Hiroyuki Morita, Masanori Katakura, Michio Hashimoto, Toshiyuki Ko, Satoshi Bujo, Yusuke Adachi, Kazutaka Ueda, Haruka Murakami, Masato Ishizuka, Jiaxi Guo, Chunxia Zhao, Takayuki Fujiwara, Hironori Hara, Norifumi Takeda, Eiki Takimoto, Osamu Shido, Mutsuo Harada, Issei Komuro

Scientific Reports 10(1) 2020年12月
Inhibition of transforming growth factor-β signaling in myeloid cells ameliorates aortic aneurysmal formation in Marfan syndrome

Hironori Hara, Sonoko Maemura, Takayuki Fujiwara, Norifumi Takeda, Satoshi Ishii, Hiroki Yagi, Takaaki Suzuki, Mutsuo Harada, Haruhiro Toko, Tsubasa Kanaya, Hideaki Ijichi, Harold L. Moses, Eiki Takimoto, Hiroyuki Morita, Hiroshi Akazawa, Issei Komuro

PLOS ONE 15(11) e0239908-e0239908 2020年11月11日
MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.

Lorna R Fiedler, Kathryn Chapman, Min Xie, Evie Maifoshie, Micaela Jenkins, Pelin Arabacilar Golforoush, Mohamed Bellahcene, Michela Noseda, Dörte Faust, Ashley Jarvis, Gary Newton, Marta Abreu Paiva, Mutsuo Harada, Daniel J Stuckey, Weihua Song, Josef Habib, Priyanka Narasimhan, Rehan Aqil, Devika Sanmugalingam, Robert Yan, Lorenzo Pavanello, Motoaki Sano, Sam C Wang, Robert D Sampson, Sunthar Kanayaganam, George E Taffet, Lloyd H Michael, Mark L Entman, Tse-Hua Tan, Sian E Harding, Caroline M R Low, Catherine Tralau-Stewart, Trevor Perrior, Michael D Schneider

Cell stem cell 26(3) 458-458 2020年3月5日査読有り
Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and Is Essential to cGMP-PDE5 Inhibition Efficacy.

Nobuaki Fukuma, Eiki Takimoto, Kazutaka Ueda, Pangyen Liu, Miyu Tajima, Yu Otsu, Taro Kariya, Mutsuo Harada, Haruhiro Toko, Kaori Koga, Robert M Blanton Jr, Richard H Karas, Issei Komuro

JACC. Basic to translational science 5(3) 282-295 2020年3月査読有り
A metabolic profile of routine needle biopsies identified tumor type specific metabolic signatures for breast cancer stratification: a pilot study.

Narumi Harada-Shoji, Tomoyoshi Soga, Hiroshi Tada, Minoru Miyashita, Mutsuo Harada, Gou Watanabe, Yohei Hamanaka, Akiko Sato, Takashi Suzuki, Akihiko Suzuki, Takanori Ishida

Metabolomics : Official journal of the Metabolomic Society 15(11) 147-147 2019年11月4日査読有り
Overview of the 83rd Annual Scientific Meeting of the Japanese Circulation Society - Renaissance of Cardiology for the Creation of Future Medicine.

Hiroshi Akazawa, Haruhiro Toko, Mutsuo Harada, Kazutaka Ueda, Satoshi Kodera, Arihiro Kiyosue, Katsuhito Fujiu, Masaru Hatano, Masao Daimon, Jiro Ando, Eiki Takimoto, Hiroyuki Morita, Issei Komuro

Circulation journal : official journal of the Japanese Circulation Society 83(9) 1829-1835 2019年8月23日査読有り
MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.

Lorna R Fiedler, Kathryn Chapman, Min Xie, Evie Maifoshie, Micaela Jenkins, Pelin Arabacilar Golforoush, Mohamed Bellahcene, Michela Noseda, Dörte Faust, Ashley Jarvis, Gary Newton, Marta Abreu Paiva, Mutsuo Harada, Daniel J Stuckey, Weihua Song, Josef Habib, Priyanka Narasimhan, Rehan Aqil, Devika Sanmugalingam, Robert Yan, Lorenzo Pavanello, Motoaki Sano, Sam C Wang, Robert D Sampson, Sunthar Kanayaganam, George E Taffet, Lloyd H Michael, Mark L Entman, Tse-Hua Tan, Sian E Harding, Caroline M R Low, Catherine Tralau-Stewart, Trevor Perrior, Michael D Schneider

Cell stem cell 24(4) 579-591 2019年4月4日査読有り
低炭水化物高脂質食による血管障害後血管リモデリングへの影響の検討

柳沢遥香, 東口治弘, 郭嘉煕, 武城怜史, 石塚理人, 原田睦生, 小室一成

日本栄養・食糧学会大会講演要旨集 73回 234-234 2019年4月

もっとみる

MISC

Cardioprotective Effects of Plant-derived Fat in Low Carbohydrate Diet on the Progression of Heart Failure

Satoshi Bujo, Haruhiro Toko, Mutsuo Harada, Guo Jiaxi, Masato Ishizuka, Haruka Yanagisawa-Murakami, Issei Komuro

CIRCULATION RESEARCH 125 2019年8月
糖質制限ダイエットに伴う心血管イベント増加メカニズムの解明 : 心臓に優しい食事の開発を目指して

小室一成, 瀧本英樹, 東口治弘, 原田睦生, 候聡志

食に関する助成研究調査報告書 (30) 73-78 2017年
Is Myocardin a limiting factor for cardiac programming?

Elisa Belian, Michela Noseda, Thomas Leja, Mutsuo Harada, Richard T. Lumbers, Marta S. Abreu Paiva, Nick East, Robert Sampson, Michael D. Schneider

CIRCULATION RESEARCH 111(12) E386-E386 2012年12月
Unmasking Phenotypic Micro-heterogeneities in Adult Cardiac Progenitor Cells: Clonal Analysis, Single Cell QRT-PCR, and Fate Mapping

Michela Noseda, Mutsuo Harada, Sara J. McSweeney, Elisa Belian, Thomas Leja, Iain Macaulay, Farah Al-Beidh, Marta S. Abreu Pavia, Richard T. Lumbers, Stephanie Koenemann, Robert Sampson, Sten E. Jacobsen, Michael D. Schneider

CIRCULATION 126(21) 2012年11月
FRS-102 Serum Soluble Receptor for Advanced Glycation End Product Level is Decreased in Acute Coronary Syndrome(Biomarker of Cardiovascular Disease, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Koyama Yo, Takeishi Yasuchika, Sasaki Toshiki, Niizeki Takeshi, Kitahara Tatsuro, Suzuki Satoshi, Nozaki Naoki, Hirono Osamu, Watanabe Tetsu, Nitobe Joji, Tsunoda Yuichi, Harada Mutsuo, Kubota Isao

Circulation journal : official journal of the Japanese Circulation Society 71 145-146 2007年3月1日
PJ-187 Pentraxin 3, a New Marker for Vascular Inflammation, is Increased in Patients with Unstable Angina Pectoris(Angina pectoris, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Sasaki Toshiki, Takeishi Yasuchika, Suzuki Satoshi, Koyama Yo, Niizeki Takeshi, Kitahara Tatsuro, Nozaki Naoki, Hirono Osamu, Watanabe Tetsu, Nitobe Joji, Tsunoda Yuichi, Harada Mutsuo, Kubota Isao

Circulation journal : official journal of the Japanese Circulation Society 71 518-518 2007年3月1日
FRS-033 Pentraxin 3, a New Marker for Vascular Inflammation, Predicts Adverse Clinical Outcomes in Patients with Heart Failure(Pathophysiology of Cardiovascular Disease, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Suzuki Satoshi, Takeishi Yasuchika, Niizeki Takeshi, Sasaki Toshiki, Koyama Yo, Kitahara Tatsuro, Nozaki Naoki, Hirono Osamu, Watanabe Tetsu, Nitobe Joji, Tsunoda Yuichi, Harada Mutsuo, Kubota Isao

Circulation journal : official journal of the Japanese Circulation Society 71 123-124 2007年3月1日
PE-222 Pre-operative Assessment for the Patients with Aortic Valve Stenosis by Multidetector Computed Tomography (MDCT)(CT/DSA-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Iwayama Tadateru, Nitobe Joji, Aoyagi Takuro, Katoh Shigehiko, Tamura Harutoshi, Nishiyama Satoshi, Harada Mutsuo, Tsunoda Yuichi, Watanabe Tetsu, Hirono Osamu, Nozaki Naoki, Takeishi Yasuchika, Kubota Isao

Circulation journal : official journal of the Japanese Circulation Society 71 380-380 2007年3月1日
DGK zeta prevents pressure overload-induced cardiac hypertrophy and progression to heart failure

Mutsuo Harada, Takanori Arimoto, Yasuchika Takeishi

CIRCULATION 114(18) 54-55 2006年10月
Diacylglycerol kinase-epsilon prevents cardiac hypertrophy induced by continuous administration of phenylephrine: A new specific regulator of Gq alpha signaling cascade

Takeshi Niizeki, Mutsuo Harada, Yo Koyama, Tatsuro Kitahara, Takanori Arimoto, Yasuchika Takeishi

CIRCULATION 114(18) 12-12 2006年10月
Diacylglycerol kinase zeta prevents cardiac remodeling by mechanical overload

Yasuchika Takeishi, Takeshi Niizeki, Mutsuo Harada, Takanori Arimoto, Isao Kubota

CIRCULATION RESEARCH 99(5) E32-E32 2006年9月
生理的心肥大と病的心肥大の遺伝子発現の相違

坂本昌也, 東口治弘, 鄒雲増, 赤澤宏, 佐野雅則, 原田睦生, 南野徹, 高野博之, 永井敏雄, 小室一成

日本臨床分子医学会学術総会プログラム・抄録集 40回 51-51 2003年7月
Effects of Torasemide on Heart Failure

Sakamoto Masaya, Toukou Haruhiro, Hasegawa Hiroshi, Zou Yun-zeng, Akazawa Hiroshi, Sano Masanori, Harada Mutsuo, Takano Hiroyuki, Nagai Toshio, Komuro Issei

Circulation journal : official journal of the Japanese Circulation Society 67 437-437 2003年3月1日
Heat Shock Proteins Are Upregulated in Exercised-lnduced Cardiac Hypertrophy But Not in Pressure Overload-Induced Cardiac Hypertrophy

Sakamoto Masaya, Toukou Haruhiro, Zou Yun-zeng, Akazawa Hiroshi, Sano Masanori, Harada Mutsuo, Takano Hiroyuki, Nagai Toshio, Komuro Issei

Circulation journal : official journal of the Japanese Circulation Society 67 144-144 2003年3月1日