論文

査読有り 国際誌
2022年4月

Disrupted social memory ensembles in the ventral hippocampus underlie social amnesia in autism-associated Shank3 mutant mice.

Molecular psychiatry
  • Kentaro Tao
  • ,
  • Myung Chung
  • ,
  • Akiyuki Watarai
  • ,
  • Ziyan Huang
  • ,
  • Mu-Yun Wang
  • ,
  • Teruhiro Okuyama

27
4
開始ページ
2095
終了ページ
2105
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41380-021-01430-5

The ability to remember conspecifics is critical for adaptive cognitive functioning and social communication, and impairments of this ability are hallmarks of autism spectrum disorders (ASDs). Although hippocampal ventral CA1 (vCA1) neurons are known to store social memories, how their activities are coordinated remains unclear. Here we show that vCA1 social memory neurons, characterized by enhanced activity in response to memorized individuals, were preferentially reactivated during sharp-wave ripples (SPW-Rs). Spike sequences of these social replays reflected the temporal orders of neuronal activities within theta cycles during social experiences. In ASD model Shank3 knockout mice, the proportion of social memory neurons was reduced, and neuronal ensemble spike sequences during SPW-Rs were disrupted, which correlated with impaired discriminatory social behavior. These results suggest that SPW-R-mediated sequential reactivation of neuronal ensembles is a canonical mechanism for coordinating hippocampus-dependent social memories and its disruption underlie the pathophysiology of social memory defects associated with ASD.

リンク情報
DOI
https://doi.org/10.1038/s41380-021-01430-5
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/35115700
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126818
ID情報
  • DOI : 10.1038/s41380-021-01430-5
  • PubMed ID : 35115700
  • PubMed Central 記事ID : PMC9126818

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