共同研究・競争的資金等の研究課題

2019年4月 - 2022年3月

社会性記憶という「概念」を表象する海馬の神経メカニズムの解析

日本学術振興会  科学研究費助成事業  特別研究員奨励費

課題番号
19J00911
体系的課題番号
JP19J00911
配分額
(総額)
4,030,000円
(直接経費)
3,100,000円
(間接経費)
930,000円

In this study, We looked at how mouse discriminating two familiar mice. During social interactions, humans and other social animals can distinguish not only between familiar and novel conspecifics (social recognition) but also between multiple familiar individuals (social specification). Recent studies have implicated another hippocampal sub-region dorsal CA2 (dCA2) in social recognition. Using modified Opto-SDT, we found that social specification memory engrams are also stored in vCA1 while social information encoded in dCA2 becomes sharpened as it travels from dCA2 to vCA1 microcircuits within CA2, thereby acquiring a progressive increase in the specification through repeating motifs of feedforward inhibition. Both the inhibition of GABAergic inhibitory neurons in CA2 and the reduced activity of excitatory neurons by ablation of oxytocin receptors in the dCA2 to vCA1 microcircuits impair social memory specification. These results suggest that the vCA1 and the multiple feedforward inhibition motifs in the dCA2 to vCA1 microcircuits are crucial for social memory specification.

リンク情報
KAKEN
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19J00911
ID情報
  • 課題番号 : 19J00911
  • 体系的課題番号 : JP19J00911