論文

査読有り
2015年10月

Sox7 is dispensable for primitive endoderm differentiation from mouse ES cells

BMC DEVELOPMENTAL BIOLOGY
  • Masaki Kinoshita
  • ,
  • Daisuke Shimosato
  • ,
  • Mariko Yamane
  • ,
  • Hitoshi Niwa

15
開始ページ
37
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s12861-015-0079-4
出版者・発行元
BIOMED CENTRAL LTD

Background: Primitive endoderm is a cell lineage segregated from the epiblast in the blastocyst and gives rise to parietal and visceral endoderm. Sox7 is a member of the SoxF gene family that is specifically expressed in primitive endoderm in the late blastocyst, although its function in this cell lineage remains unclear.
Results: Here we characterize the function of Sox7 in primitive endoderm differentiation using mouse embryonic stem (ES) cells as a model system. We show that ectopic expression of Sox7 in ES cells has a marginal effect on triggering differentiation into primitive endoderm-like cells. We also show that targeted disruption of Sox7 in ES cells does not affect differentiation into primitive endoderm cells in embryoid body formation as well as by forced expression of Gata6.
Conclusions: These data indicate that Sox7 function is supplementary and not essential for this differentiation from ES cells.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1186/s12861-015-0079-4
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26475439
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000362879300001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1186/s12861-015-0079-4
  • ISSN : 1471-213X
  • PubMed ID : 26475439
  • Web of Science ID : WOS:000362879300001

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