論文

査読有り
2021年7月15日

Essential roles of plexin-B3+ oligodendrocyte precursor cells in the pathogenesis of Alzheimer’s disease

Communications Biology
  • Naomi Nihonmatsu-Kikuchi
  • ,
  • Xiu-Jun Yu
  • ,
  • Yoshiki Matsuda
  • ,
  • Nobuyuki Ozawa
  • ,
  • Taeko Ito
  • ,
  • Kazuhito Satou
  • ,
  • Tadashi Kaname
  • ,
  • Yasushi Iwasaki
  • ,
  • Akio Akagi
  • ,
  • Mari Yoshida
  • ,
  • Shuta Toru
  • ,
  • Katsuiku Hirokawa
  • ,
  • Akihiko Takashima
  • ,
  • Masato Hasegawa
  • ,
  • Toshiki Uchihara
  • ,
  • Yoshitaka Tatebayashi

4
870
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s42003-021-02404-7
出版者・発行元
Springer Science and Business Media LLC

<title>Abstract</title>The role of oligodendrocyte lineage cells, the largest glial population in the adult central nervous system (CNS), in the pathogenesis of Alzheimer’s disease (AD) remains elusive. Here, we developed a culture method for adult oligodendrocyte progenitor cells (aOPCs). Fibroblast growth factor 2 (FGF2) promotes survival and proliferation of NG2+ aOPCs in a serum-free defined medium; a subpopulation (~5%) of plexin-B3+ aOPCs was also found. FGF2 withdrawal decreased NG2+, but increased plexin-B3+ aOPCs and Aβ1-42 secretion. Plexin-B3+ aOPCs were distributed throughout the adult rat brain, although less densely than NG2+ aOPCs. Spreading depolarization induced delayed cortical plexin-B3+ aOPC gliosis in the ipsilateral remote cortex. Furthermore, extracellular Aβ1-42 accumulation was occasionally found around plexin-B3+ aOPCs near the lesions. In AD brains, virtually all cortical SPs were immunostained for plexin-B3, and plexin-B3 levels increased significantly in the Sarkosyl-soluble fractions. These findings suggest that plexin-B3+ aOPCs may play essential roles in AD pathogenesis, as natural Aβ-secreting cells.

リンク情報
DOI
https://doi.org/10.1038/s42003-021-02404-7
URL
http://www.nature.com/articles/s42003-021-02404-7.pdf
URL
http://www.nature.com/articles/s42003-021-02404-7
ID情報
  • DOI : 10.1038/s42003-021-02404-7
  • eISSN : 2399-3642
  • ORCIDのPut Code : 97019664

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