2008年11月
Potentiation of the Antidepressant-Like Effect of Fluoxetine by Aripiprazole in the Mouse Tail Suspension Test
JOURNAL OF PHARMACOLOGICAL SCIENCES
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- 巻
- 108
- 号
- 3
- 開始ページ
- 381
- 終了ページ
- 384
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1254/jphs.08201SC
- 出版者・発行元
- JAPANESE PHARMACOLOGICAL SOC
We examined the effect of the novel atypical antipsychotic drug aripiprazole alone or in combination with the selective serotonin reuptake inhibitor fluoxetine in the mouse tail, Suspension test. We also investigated the effect of aripiprazole on glucose metabolism. Combined treatment with aripiprazole and a sub-effective dose Of fluoxetine significantly decreased the duration of immobility in the tail suspension test. Aripiprazole by itself did not affect the duration of immobility. While olanzapine significantly increased blood glucose level in the glucose tolerance test, aripiprazole did not affect glucose metabolism. We suggest that aripiprazole augments the antidepressant-like effect of fluoxetine without affecting glucose metabolism.
- リンク情報
- ID情報
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- DOI : 10.1254/jphs.08201SC
- ISSN : 1347-8613
- PubMed ID : 18987428
- Web of Science ID : WOS:000261353400018