2016年8月
Nonrandom Germline Transmission of Mouse spermatogonial Stem Cells
DEVELOPMENTAL CELL
- ,
- ,
- 巻
- 38
- 号
- 3
- 開始ページ
- 248
- 終了ページ
- 261
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.devcel.2016.07.011
- 出版者・発行元
- CELL PRESS
Genes are thought to be transmitted to offspring by random fertilization of a small number of oocytes with numerous spermatozoa. Here we analyzed the dynamics of male germline transmission by genetic marking and transplantation of spermatogonial stem cells (SSCs). We found that offspring deriving from a small number of specific SSCs appear within a limited time. Interestingly, the same SSC clones reappear later with an average functional lifespan of similar to 124.4 days. Cyclic offspring production from SSCs was not caused by changes in SSC self renewal activity because lineage-tracing analyses suggested that all SSCs actively proliferated. Selection appears to occur during the differentiating spermatogonia stage, when extensive apoptosis was observed. The pattern of germline transmission could be predicted using a mathematical model in which SSCs repeat cycles of transient spermatogenic burst and refractory periods. Thus, spermatogenesis is a regulated process whereby specific SSC clones are repeatedly recruited for fertilization with long-term cycles.
- リンク情報
- ID情報
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- DOI : 10.1016/j.devcel.2016.07.011
- ISSN : 1534-5807
- eISSN : 1878-1551
- J-Global ID : 201702209383296200
- Web of Science ID : WOS:000381246500005