Narufumi Kitamura

Profile Information

Affiliation: Associate Professor, -

Degree: Ph.D in Engineering(Sep, 2011, Kyoto University)

Researcher number: 50624912
J-GLOBAL ID: 201801003506004974
researchmap Member ID: B000318667

External link: https://www.medphys.med.tohoku.ac.jp/

Research Interests

Research Areas

Research History

Jun, 2021 - Present

Associate Professor, Department of Medical Physics, Graduate School of Medicine, Tohoku University
Feb, 2019 - May, 2021

Lecturer, Department of Medical Physics, Graduate School of Medicine, Tohoku University
Apr, 2017 - Jan, 2019

Assistant Professor, Department of Medical Physics, Graduate School of Medicine, Tohoku University
Oct, 2013 - Mar, 2017

Assistant Professor, Department of Surgical Oncology, Graduate School of Medicine, Tohoku University
Oct, 2011 - Oct, 2013

Postdoctoral fellow, Department of Reparative Materials, Institute for Frontier Medical Sciences, Kyoto University
Apr, 2006 - Sep, 2007

KASYU CO., LTD.

Education

Oct, 2008 - Sep, 2011

Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University
Oct, 2007 - Sep, 2008

Department of Chemical Engineering, Graduate School of Engineering, Kyoto University
Apr, 2005 - Mar, 2006

Department of Chemical Engineering, Graduate School of Engineering, Kyoto University
Apr, 2000 - Mar, 2005

Undergraduate School of Industrial Chemistry, Faculty of Engineering, Kyoto University

Papers

Mitochondrial dynamics as a novel treatment strategy for triple-negative breast cancer.

Yuechen Wang, Narumi Harada-Shoji, Narufumi Kitamura, Yuto Yamazaki, Akiko Ebata, Masakazu Amari, Mika Watanabe, Minoru Miyashita, Hiroshi Tada, Takaaki Abe …

Cancer medicine, 13(2) e6987, Jan, 2024
Clinical Significance of ABCG2/BCRP Quantified by Fluorescent Nanoparticles in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

Hiroshi Tada, Kohsuke Gonda, Narufumi Kitamura, Takanori Ishida

Cancers, 15(8) 2365-2365, Apr 18, 2023 Peer-reviewed
Development of gold-coated magnetic nanoparticles as a theranostic agent for magnetic hyperthermia and CT imaging applications

Loi Tonthat, Mone Kimura, Tomoyuki Ogawa, Narufumi Kitamura, Yoshio Kobayashi, Kohsuke Gonda, Shin Yabukami

AIP Advances, 13(2) 025239-025239, Feb 1, 2023 Peer-reviewed
X-ray irradiation negatively affects immune responses in the lymphatic network

Sawa Kanabuchi, Narufumi Kitamura, Mayumi Takano-Kasuya, Tomoya Inose, Chihiro Nishidate, Mizuki Yamanashi, Makoto Kudo, Tatsuki Ito, Naho Ito, Hiroshi Okamoto …

Microvascular Research, 104511-104511, Feb, 2023 Peer-reviewed
Development of X-ray contrast agents using single nanometer-sized gold nanoparticles and lactoferrin complex and their application in vascular imaging

Tomoya Inose, Narufumi Kitamura, Mayumi Takano-Kasuya, Masayuki Tokunaga, Norikazu Une, Chihiro Kato, Mayu Tayama, Yukina Kobayashi, Noriko Yamauchi, Daisuke Nagao …

Colloids and Surfaces B: Biointerfaces, 203 111732-111732, Jul, 2021 Peer-reviewed
The anti-angiogenic agent lenvatinib induces tumor vessel normalization and enhances radiosensitivity in hepatocellular tumors

Norikazu Une, Mayumi Takano-Kasuya, Narufumi Kitamura, Mineto Ohta, Tomoya Inose, Chihiro Kato, Ryuichi Nishimura, Hiroshi Tada, Shigehito Miyagi, Takanori Ishida …

Medical Oncology, 38(6) 60-60, Jun, 2021 Peer-reviewed
【蛍光イメージングと癌治療】蛍光イメージングによる抗体医薬の創薬支援および薬効予測診断

権田幸祐, 根岸洋, 高野真由美, 北村成史, 古澤直子, 中野寧, 多田寛, 石田孝宣

癌と化学療法, 48(2) 170-175, Feb, 2021
[Supporting Technology for Development of Antibody Drug and Diagnostic Method to Predict Response to the Drug, by Using Fluorescence Imaging].

Kohsuke Gonda, Hiroshi Negishi, Mayumi Takano-Kasuya, Narufumi Kitamura, Naoko Furusawa, Yasushi Nakano, Hiroshi Tada, Takanori Ishida

Gan to kagaku ryoho. Cancer & chemotherapy, 48(2) 170-175, Feb, 2021
Heterogeneous Drug Efficacy of an Antibody-Drug Conjugate Visualized Using Simultaneous Imaging of Its Delivery and Intracellular Damage in Living Tumor Tissues

Kohsuke Gonda, Hiroshi Negishi, Mayumi Takano-Kasuya, Narufumi Kitamura, Naoko Furusawa, Yasushi Nakano, Yoh Hamada, Masayuki Tokunaga, Hideo Higuchi, Hiroshi Tada …

TRANSLATIONAL ONCOLOGY, 13(6) 100764-100764, Jun, 2020 Peer-reviewed
A millisecond structured illumination microscope for super-resolution live cell imaging

Tomu Suzuki, Shinji Kajimoto, Narufumi Kitamura, Mayumi Takano-Kasuya, Naoko Furusawa, Yasushi Nakano, Hiroshi Fukumura, Kohsuke Gonda, Takakazu Nakabayashi

Applied Physics Express, 13(4) 045002 (4 page), Mar, 2020 Peer-reviewed
核外ERαの定量分析に基づくHR+/HER2乳癌の内分泌療法抵抗性の予測(Prediction of endocrine therapy resistance in HR+/HER2 breast cancer based on quantitative analysis of extranuclear ERα)

北村成史, 多田寛, 濱田庸, 宮下穣, 原田成美, 濱中洋平, 坪井洸樹, 大内憲明, 林慎一, 石田孝宣 …

日本癌学会総会記事, 78回 J-1030, Sep, 2019
Automated Quantification of Extranuclear ERα using Phosphor-integrated Dots for Predicting Endocrine Therapy Resistance in HR+/HER2- Breast Cancer.

Zhaorong Guo, Hiroshi Tada, Narufumi Kitamura, Yoh Hamada, Minoru Miyashita, Narumi Harada-Shoji, Akiko Sato, Yohei Hamanaka, Kouki Tsuboi, Nobuhisa Harada …

Cancers, 11(4), Apr 12, 2019 Peer-reviewed
Quantitative analyses of amount and localization of radiosensitizer gold nanoparticles interacting with cancer cells to optimize radiation therapy

Keiichiro Hatoyama, Narufumi Kitamura, Mayumi Takano-Kasuya, Masayuki Tokunaga, Takahiro Oikawa, Mineto Ohta, Yoh Hamada, Hiroshi Tada, Yoshio Kobayashi, Takashi Kamei …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 508(4) 1093-1100, Jan, 2019 Peer-reviewed
Quantitative diagnosis of HER2 protein expressing breast cancer by single-particle quantum dot imaging

Minoru Miyashita, Kohsuke Gonda, Hiroshi Tada, Mika Watanabe, Narufumi Kitamura, Takashi Kamei, Hironobu Sasano, Takanori Ishida, Noriaki Ohuchi

CANCER MEDICINE, 5(10) 2813-2824, Oct, 2016 Peer-reviewed
X-ray computed tomography imaging of a tumor with high sensitivity using gold nanoparticles conjugated to a cancer-specific antibody via polyethylene glycol chains on their surface

Tomohiko Nakagawa, Kohsuke Gonda, Takashi Kamei, Liman Cong, Yoh Hamada, Narufumi Kitamura, Hiroshi Tada, Takanori Ishida, Takuji Aimiya, Naoko Furusawa …

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, 17(1) 387-397, 2016 Peer-reviewed
Interaction between cells and poly(ethylene glycol)-lipid conjugates

Toru Itagaki, Yusuke Arima, Rei Kuwabara, Narufumi Kitamura, Hiroo Iwata

COLLOIDS AND SURFACES B-BIOINTERFACES, 135 765-773, Nov, 2015 Peer-reviewed
A DNA hybridization system for labeling of neural stem cells with SPIO nanoparticles for MRI monitoring post-transplantation

Edgar Y. Egawa, Narufumi Kitamura, Ryusuke Nakai, Yusuke Arima, Hiroo Iwata

BIOMATERIALS, 54 158-167, Jun, 2015 Peer-reviewed
Highly Sensitive Imaging of Cancer with Functional Nanoparticles

Kohsuke Gonda, Yoh Hamada, Narufumi Kitamura, Hiroshi Tada, Minoru Miyashita, Takashi Kamei, Takanori Ishida, Noriaki Ohuchi

JOURNAL OF PHOTOPOLYMER SCIENCE AND TECHNOLOGY, 28(6) 731-736, 2015 Peer-reviewed
Labeling of islet cells with iron oxide nanoparticles through DNA hybridization for highly sensitive detection by MRI

Narufumi Kitamura, Ryusuke Nakai, Haruyasu Kohda, Keiko Furuta-Okamoto, Hiroo Iwata

BIOORGANIC & MEDICINAL CHEMISTRY, 21(22) 7175-7181, Nov, 2013 Peer-reviewed
Heat-initiated detection for reduced glutathione with F-19 NMR probes based on modified gold nanoparticles

Narufumi Kitamura, Kazuo Tanaka, Yoshiki Chujo

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 23(1) 281-286, Jan, 2013 Peer-reviewed

Misc.

Nanomedicine Using Photosensitive Nanoparticles

西館智尋, 金野智浩, 坂本武琉, 木下菜月, 鳥井猛流, 橋本佳樹, 川内敬子, 三好大輔, 今井陽介, 小林芳男 …

ナノ学会大会講演予稿集, 20th, 2022
Visualization of Biological Information and Quantitative Evaluation of Pathological Conditions Using Functional Nanoparticles

Narufumi Kitamura, Hiroshi Tada, Mayumi Takano-Kasuya, Yoshio Kobayashi, Takanori Ishida, Takasi Kamei, Kohsuke Gonda

化学工業, 72(4) 258-267, Apr, 2021 Lead author
血管新生阻害剤に対する薬剤耐性を回避する新たな腫瘍兵糧攻め療法の開発

加藤智尋, 北村成史, 徳永正之, 濱田庸, 鳩山恵一朗, 高野真由美, 福原武志, 今井陽介, 権田幸祐

日本心血管内分泌代謝学会学術総会プログラム及び抄録集, 23rd, 2019
Quantification of protein heterodimers by using fluorescent nanoparticles for breast cancer diagnosis

Narufumi Kitamura, Hiroshi Tada, Kohsuke Gonda

CANCER SCIENCE, 109 521-521, Dec, 2018
乳がん診断技術への応用を指向した蛍光ナノ粒子によるタンパク質ヘテロダイマーの定量(Quantification of protein heterodimers by using fluorescent nanoparticles for breast cancer diagnosis)

北村成史, 多田寛, 権田幸祐

日本癌学会総会記事, 77回 557-557, Sep, 2018
Prognostic value of nuclear and non-nuclear estrogen receptor expression by immunohistochemistry with phosphor-integrated dots in hormone receptor-positive early breast cancer

Zhaorong Guo, Hiroshi Tada, Narufumi Kitamura, Yoh Hamada, Shin-ichi Hayashi, Noriaki Ohuchi, Kosuke Gonda, Takanori Ishida

CANCER RESEARCH, 78(13), Jul, 2018
金ナノ粒子を用いたがん転移リンパ節への光熱療法の開発

及川隆洋, 権田幸祐, 高野真由美, 猪瀬智也, 徳永正之, 北村成史, 小林芳男, 鳩山恵一朗, 小野寺優, 石田裕嵩 …

日本外科学会定期学術集会抄録集, 118回 2119-2119, Apr, 2018
腫瘍血管に対するVEGF標的薬の効果を高感度4次元X線CTイメージングで解析する

徳永正之, 北村成史, 濱田庸, 高野真由美, 今井陽介, 権田幸祐

日本心血管内分泌代謝学会学術総会プログラム及び抄録集, 21st 110, 2017
新規蛍光ナノ粒子を用いた乳癌バイオマーカーの高感度定量評価

郭ショウ蓉, 多田寛, 北村成史, 濱田庸, 権田幸祐, 大内憲明

日本癌学会総会記事, 75回 P-2156, Oct, 2016
Development and evaluation of labeled islet cells using iron oxide nanoparticles and DNA hybridization.

Nakai R, Kitamura N, Iwata Hi

Joint Annual Meeting ISMRM & ESMRMB 2014, 2014 Peer-reviewed

Teaching Experience

Apr, 2022 - Present

Information and data literacy (Tohoku Universit)
Oct, 2020 - Present

Topics and Discussions "Design and syhthesis of functional nanoparticles for bioimaging" (Tohoku University)
Oct, 2018 - Present

Tequniques in Nuclear Medicine (Tohoku University)
Oct, 2018 - Present

Fundamentals of Electrical Engineering (Tohoku University)
Apr, 2018 - Present

Experiments on Radiochemistry (Tohoku University)
Apr, 2019 - Sep, 2021

Information Science Basics A (Tohoku University)
Oct, 2019 - Feb, 2020

Biochemistry (Tohoku University)

Professional Memberships

Research Projects

非標準的遺伝子四重鎖への効果的薬剤送達を基盤とする新規光線力学療法の開発

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

北村成史, 石田孝宣, 亀井尚, 多田寛, 金野智浩, 権田幸祐
プロテオーム・メタボローム解析による乳癌の新規悪性度評価と代謝標的治療効果予測

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

多田寛, 権田幸祐, 石田孝宣, 原田成美, 北村成史
リンパネットワークのメカノバイオ解析に基づくリンパ節転移機序の解明と診断技術開発

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

高野真由美, 北村成史, 権田幸祐
放射線治療に有用なアブスコパル効果の発現機序解明と応用

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2025

権田幸祐, 多田寛, 北村成史
Development of new cancer therapy by tumor blood vessel-specific radiation therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2022

GONDA Kohsuke
Development of early-stage cancer detection method and radiotherapy using ultra-small gold nanoparticles

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Kitamura Narufumi
Clinical significance of ABCG2/BCRP quantified by fluorescence nanoparticle in breast cancer patients undergoing neoadjuvant chemotherapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2022

TADA Hiroshi
Detection of HER family dimers and prediction of anticancer drug efficacy based on single particle imaging

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019

Kitamura Narufumi
Three dimensional tissue regeneration through multipoint molecular weak association

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2016

IWATA Hiroo, OKAMOTO Yukihiro, KITAMURA Narufumi, ARIMA Yusuke
Development of direct monitoring method for transplanted cells by MRI based on cell-labeling with SPIO

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

KITAMURA Narufumi

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