Norikazu Ichihashi

Profile Information

Affiliation: Professor, Graduate School of Arts and Sciences, The University of Tokyo

J-GLOBAL ID: 200901096339039360
researchmap Member ID: 5000090983

Research Interests

Research Areas

Research History

Jan, 2019 - Present

Graduate School of Arts and Sciences, The University of Tokyo
Jan, 2013 - Dec, 2018

Graduate School of Information Science and Technology, Osaka University
Jan, 2010 - Jun, 2013

Japan Science and Technology Agency
Apr, 2008 - Dec, 2009

Graduate School of Information Science and Technology, Osaka University
Apr, 2006 - Mar, 2008

Japan Science and Technology Agency
2005 - 2007

JST ERATO Kaneko Complex system project

Education

Apr, 2001 - Mar, 2006

Graduate School of Pharmaceutical Sciences, The University of Tokyo
Apr, 1997 - Mar, 2001

The University of Tokyo

Committee Memberships

Awards

Papers

Emergence of linkage between cooperative RNA replicators encoding replication and metabolic enzymes through experimental evolution.

Kensuke Ueda, Ryo Mizuuchi, Norikazu Ichihashi

PLoS genetics, 19(8) e1010471, Aug 4, 2023
Minimal RNA self-reproduction discovered from a random pool of oligomers.

Ryo Mizuuchi, Norikazu Ichihashi

Chemical science, 14(28) 7656-7664, Jul 19, 2023
Investigation of Compatibility between DNA Replication, Transcription, and Translation for in Vitro Central Dogma.

Kaito Seo, Norikazu Ichihashi

ACS synthetic biology, 12(6) 1813-1822, Jun 16, 2023
Progresses in Cell-Free In Vitro Evolution.

Kaito Seo, Katsumi Hagino, Norikazu Ichihashi

Advances in biochemical engineering/biotechnology, Jun 13, 2023
In Vitro Transcription/Translation-Coupled DNA Replication through Partial Regeneration of 20 Aminoacyl-tRNA Synthetases.

Katsumi Hagino, Norikazu Ichihashi

ACS synthetic biology, 12(4) 1252-1263, Apr 21, 2023
How prebiotic complexity increases through Darwinian evolution

Kohtoh Yukawa, Ryo Mizuuchi, Norikazu Ichihashi

Current Opinion in Systems Biology, 100456-100456, Apr, 2023
Cell-free expression of RuBisCO for ATP production in the synthetic cells.

Shugo Sugii, Katsumi Hagino, Ryo Mizuuchi, Norikazu Ichihashi

Synthetic biology (Oxford, England), 8(1) ysad016, 2023
Plausible pathway for a host-parasite molecular replication network to increase its complexity through Darwinian evolution.

Rikuto Kamiura, Ryo Mizuuchi, Norikazu Ichihashi

PLoS computational biology, 18(12) e1010709, Dec, 2022
Genetic analysis of Bacillus subtilis stable L-forms obtained via long-term cultivation.

Kazuki Ohta, Tenma Shimizu, Taku Oshima, Norikazu Ichihashi

The Journal of general and applied microbiology, 69(1) 45-52, Nov 15, 2022
Experimental evidence for the correlation between RNA structural fluctuations and the frequency of beneficial mutations.

Yutaro Maeda, Ryo Mizuuchi, Shuji Shigenobu, Atsushi Shibai, Hazuki Kotani, Chikara Furusawa, Norikazu Ichihashi

RNA (New York, N.Y.), Oct 4, 2022
Transfer RNA Synthesis-Coupled Translation and DNA Replication in a Reconstituted Transcription/Translation System.

Ryota Miyachi, Yoshihiro Shimizu, Norikazu Ichihashi

ACS synthetic biology, 11(8) 2791-2799, Aug 19, 2022
Evolutionary transition from a single RNA replicator to a multiple replicator network.

Ryo Mizuuchi, Taro Furubayashi, Norikazu Ichihashi

Nature communications, 13(1) 1460-1460, Mar 18, 2022
How evolution builds up complexity?: In vitro evolution approaches to witness complexification in artificial molecular replication systems.

Taro Furubayashi, Norikazu Ichihashi

Biophysics and physicobiology, 19 1-10, 2022
Relaxed Substrate Specificity in Qβ Replicase through Long-Term In Vitro Evolution.

Kohtoh Yukawa, Ryo Mizuuchi, Norikazu Ichihashi

Life (Basel, Switzerland), 12(1), Dec 26, 2021
Continuous Cell-Free Replication and Evolution of Artificial Genomic DNA in a Compartmentalized Gene Expression System.

Hiroki Okauchi, Norikazu Ichihashi

ACS synthetic biology, 10(12) 3507-3517, Dec 17, 2021
Primitive Compartmentalization for the Sustainable Replication of Genetic Molecules.

Ryo Mizuuchi, Norikazu Ichihashi

Life (Basel, Switzerland), 11(3), Feb 28, 2021
Exchange of proteins in liposomes through streptolysin O pores.

Gakushi Tsuji, Takeshi Sunami, Masaya Oki, Norikazu Ichihashi

Chembiochem : a European journal of chemical biology, 22(11) 1966-1973, Feb 14, 2021
人工RNA複製システムの実験進化による物質から生命への複雑化プロセスの探求

Taro FURUBAYASHI, Norikazu ICHIHASHI

Seibutsu Butsuri, 61(4) 240-244, 2021
Translation-coupled RNA replication and parasitic replicators in membrane-free compartments.

Ryo Mizuuchi, Norikazu Ichihashi

Chemical communications (Cambridge, England), 56(87) 13453-13456, Nov 3, 2020
Emergence and diversification of a host-parasite RNA ecosystem through Darwinian evolution.

Taro Furubayashi, Kensuke Ueda, Yohsuke Bansho, Daisuke Motooka, Shota Nakamura, Ryo Mizuuchi, Norikazu Ichihashi

eLife, 9, Jul 21, 2020 Peer-reviewed

Misc.

How evolution builds up complexity? : In vitro evolution approaches to witness complexification in artificial molecular replication systems

Taro Furubayashi, Norikazu Ichihashi

BIOPHYSICS AND PHYSICOBIOLOGY, 19, 2022
遺伝情報が複雑化したRNAによる単純な情報をもつRNA集団への侵入

植田健介, 水内良, 松田史生, 市橋伯一

日本進化学会大会プログラム・講演要旨集(Web), 21st, 2019
協力関係にある2種類のRNA,一本化RNAの相対適応度に栄養制限条件が及ぼす影響

植田健介, 水内良, 松田史生, 市橋伯一

日本進化学会大会プログラム・講演要旨集(Web), 20th, 2018
遺伝子発現と共役するゲノムDNA複製系をin vitroで確立する

酒谷佳寛, 松田史生, 市橋伯一

日本生物工学会大会講演要旨集, 70th, 2018
実験進化により非転写後修飾リボソームRNAの翻訳活性を向上する

江田航平, 村瀬由樹, 松田史生, 市橋伯一

日本進化学会大会プログラム・講演要旨集(Web), 20th, 2018
2Dp18 Kinetic analysis of β-galactosidase and β-glucuronidase tetramerization coupled with protein translation

Matsuura Tomoaki, Hosoda kazufumi, Ichihashi Norikazu, Kazuta Yasuaki, Yomo Tetsuya

63 139-139, 2011
Importance of Translation-Replication Balance for Efficient Replication by the Self-Encoded Replicase

Norikazu Ichihashi, Tomoaki Matsuura, Hiroshi Kita, Kazufumi Hosoda, Takeshi Sunami, Koji Tsukada, Tetsuya Yomo

CHEMBIOCHEM, 9(18) 3023-3028, Dec, 2008
Importance of Translation-Replication Balance for Efficient Replication by the Self-Encoded Replicase

Norikazu Ichihashi, Tomoaki Matsuura, Hiroshi Kita, Kazufumi Hosoda, Takeshi Sunami, Koji Tsukada, Tetsuya Yomo

CHEMBIOCHEM, 9(18) 3023-3028, Dec, 2008
Replication of Genetic Information with Self-Encoded Replicase in Liposomes

Hiroshi Kita, Tomoaki Matsuura, Takeshi Sunami, Kazufumi Hosoda, Norikazu Ichihashi, Koji Tsukada, Itaru Urabe, Tetsuya Yomo

CHEMBIOCHEM, 9(15) 2403-2410, Oct, 2008
Replication of Genetic Information with Self-Encoded Replicase in Liposomes

Hiroshi Kita, Tomoaki Matsuura, Takeshi Sunami, Kazufumi Hosoda, Norikazu Ichihashi, Koji Tsukada, Itaru Urabe, Tetsuya Yomo

CHEMBIOCHEM, 9(15) 2403-2410, Oct, 2008
A novel sequence-specific RNA quantification method using nicking endonuclease, dual-labeled fluorescent DNA probe, and conformation-interchangeable oligo-DNA

Kazufumi Hosoda, Tomoaki Matsuura, Hiroshi Kita, Norikazu Ichihashi, Koji Tsukada, Itaru Urabe, Tetsuya Yomo

RNA-A PUBLICATION OF THE RNA SOCIETY, 14(3) 584-592, Mar, 2008
A novel sequence-specific RNA quantification method using nicking endonuclease, dual-labeled fluorescent DNA probe, and conformation-interchangeable oligo-DNA

Kazufumi Hosoda, Tomoaki Matsuura, Hiroshi Kita, Norikazu Ichihashi, Koji Tsukada, Itaru Urabe, Tetsuya Yomo

RNA-A PUBLICATION OF THE RNA SOCIETY, 14(3) 584-592, Mar, 2008
遺伝情報が自己複製するために必要な条件を明らかにする

2008
Kinetic analysis of the entire RNA amplification process by Q beta replicase

Kazufumi Hosoda, Tomoaki Matsuura, Hiroshi Kita, Norikazu Ichihashi, Koji Tsukada, Tetsuya Yomo

JOURNAL OF BIOLOGICAL CHEMISTRY, 282(21) 15516-15527, May, 2007
Kinetic analysis of the entire RNA amplification process by Q beta replicase

Kazufumi Hosoda, Tomoaki Matsuura, Hiroshi Kita, Norikazu Ichihashi, Koji Tsukada, Tetsuya Yomo

JOURNAL OF BIOLOGICAL CHEMISTRY, 282(21) 15516-15527, May, 2007
RNAとタンパク質からなる人工自己複製系の速度論的解析

2007
黄色ブドウ球菌DnaAの活性制御機構の普遍性と独自性

水村光, 黒川健児, 高木亨, 市橋伯一, 関水和久

日本分子生物学会年会講演要旨集, 28th, 2005
黄色ブドウ球菌dnaA変異株の分離と脂質代謝関連遺伝子による抑圧

村井長元, 黒川健児, 市橋伯一, 松尾美記, 関水和久

日本分子生物学会年会プログラム・講演要旨集, 27th, 2004
DNA複製開始蛋白DnaAと塩基性リン脂質合成酵素MprFの遺伝的相互作用

市橋伯一, 黒川健児, 関水和久

日本分子生物学会年会プログラム・講演要旨集, 26th, 2003
黄色ブドウ球菌DnaAタンパクの活性制御機構に関する研究

石井裕美子, 黒川健児, 市橋伯一, 関水和久

日本分子生物学会年会プログラム・講演要旨集, 26th, 2003

Books and Other Publications

増えるものたちの進化生物学

市橋, 伯一

筑摩書房, Apr, 2023 (ISBN: 9784480684462)
協力と裏切りの生命進化史

市橋伯一

光文社新書, 2019

Presentations

自律進化し自己増殖する分子システムの構築に向けて

市橋伯一

第6回分子サイバネティクス・第50回分子ロボティクス定例研究会, Jun 29, 2023 Invited
Development of diversity and ecological complexity in the experimental evolution of an RNA-protein replicator

Norikazu Ichihashi

Molecular Origin of Life 2023, Jun 21, 2023 Invited
作ることによって(たぶん)わかる生命機能の偶然と必然

市橋伯一

微生物コンソーシアム, May 30, 2023 Invited
無生物を進化させると生命らしさを獲得するのか？

市橋伯一

南部コロキウム, May 11, 2023 Invited
細胞外で複製し進化する人工ゲノムDNAの開発

市橋伯一

JBA講演会, Mar 15, 2023 Invited
What we can learn from creating life-like things?

Norikazu Ichihashi

Japanese-Canadian Frontiers of Science Symposium, Mar 8, 2023
自己複製分子を進化させると何が起こるのか？

市橋伯一

バイオ単分子研究会, Feb 8, 2023 Invited
How does an RNA-protein replicator develop diversity and complexity through Darwinian evolution?

NASA PCE3 workshop, Oct 19, 2022 Invited
How does an RNA-protein replicator develop diversity and complexity through Darwinian evolution?

Oct 19, 2022 Invited
どうやったら非生命から生命性が生まれるのか？

市橋伯一

生物情報若手の会, Sep 10, 2022 Invited
増殖し進化する分子システムをつくることで生命の可能性を探る

市橋伯一

極限環境生物学会シンポジウム, Jul 2, 2022 Invited
自己複製RNAの進化が生み出す寄生と共生

市橋伯一

共生進化機構先端セミナー, Jun 2, 2022 Invited
自己複製RNAを長期進化させると生命らしさが生まれるか？

市橋伯一

ExCellsセミナー, Mar 28, 2022 Invited
細胞外で複製し進化する人工ゲノムDNAの開発

市橋伯一

JBAセミナー, Feb 14, 2022 Invited
RNAの構造揺らぎから進化しやすさを予想する

市橋伯一

2021年分子生物学会年会, Dec 1, 2021 Invited
人工ゲノムRNAと寄生型RNAの長期共進化は何をもたらすのか？

市橋伯一

抗酸菌研究会, Nov 20, 2021 Invited
物質から生命へ至る合成生物学

市橋伯一

宇宙普遍生物学セミナー, Nov 4, 2021 Invited
Relaxed substrate specificity of polymerase through in vitro evolution may provide a possible scenario for the transition from the RNA world to the DNA world

Norikazu Ichihashi

JSME 2021, Nov 1, 2021 Invited
How does an RNA-protein replicator develop diversity and complexity through Darwinian evolution?

Norikazu Ichihashi

International Society for the Study of the Origin of Life, Oct 19, 2021 Invited
生物のように自己増殖する分子システムの開発に向けて

市橋伯一

2021年「自然に学ぶものづくり」フォーラム, Oct 15, 2021 Invited

Research Projects

人工細胞システムを用いた核酸医薬合成に資するポリメレースの人為進化

科学研究費助成事業学術変革領域研究(A), 学術変革領域研究(A), 日本学術振興会, Jun, 2022 - Mar, 2024

市橋伯一
Predict and regulate the evolvability from the fluctuation of RNA structure

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2022
人工RNA進化システムを用いたRNAの構造揺らぎと進化の関係の解析

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2018 - Mar, 2020

市橋伯一
Experimental evolution of an primitive cell model to understand possible evolutionary process

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Jul, 2015 - Mar, 2020

Ichihashi Norikazu
RNA進化を可能にする冥王代の細胞構造の探索

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2017 - Mar, 2019

市橋伯一
Experimental demonstration and understanding of host-parasite coevolution

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Norikazu Ichihashi
新生鎖研究のためのリボソームin vitro人為選択技術の開発

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2015 - Mar, 2017

市橋伯一
Examination of the codon-acquisition hypothesis in the early evolution of life

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

ICHIHASHI Norikazu
Construction of an experimental model system that mimic the evolution of early life

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A), Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

ICHIHASHI Norikazu
Experimental verification of the requirement of micro-environment for continuous self-replication system.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2009 - 2010

ICHIHASHI Norikazu
塩基性、酸性リン脂質によるDNA複製開始タンパクDnaAの活性制御機構の解明

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2004 - 2005

市橋伯一
構成的アプローチによる自己複製システムの理解
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Media Coverage

試験管で再現したRNA生命体の進化

日経サイエンス, Jul, 2022 Newspaper, magazine
原始の生命、進化を模擬～東大チーム試験管内で再現実験

日本経済新聞, Apr, 2022 Newspaper, magazine
非生命から生命へ

JT生命誌博物館, 季刊生命誌, Dec, 2020 Promotional material
原始生命体の進化のかぎは「寄生体」

Newton, Nov, 2020 Newspaper, magazine
物質が「寄生体」に変化

日経新聞, Nov, 2020 Newspaper, magazine

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Misc.

Books and Other Publications

Presentations

Research Projects

Media Coverage

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