2020年9月
Coupling between infraslow activities and high-frequency oscillations precedes seizure onset.
Epilepsia open
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- 巻
- 5
- 号
- 3
- 開始ページ
- 501
- 終了ページ
- 506
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/epi4.12425
- 出版者・発行元
- Wiley
Infraslow activities and high-frequency oscillations (HFOs) are observed in seizure-onset zones. However, the relation between them remains unclear. In this study, we investigated phase-amplitude coupling between infraslow phase (0.016-1 Hz) and HFOs' amplitude of focal impaired awareness seizures followed by focal to bilateral tonic-clonic seizures, in a 28-year-old right-handed man with a dysembryoplastic neuroepithelial tumor. We recorded five habitual seizures. After the time of seizure onset, a significant increase in the power of HFOs was observed, and the power was significantly coupled with θ (4-8 Hz) phase. In contrast, coupling of infraslow activities and HFOs surged a few minutes before the seizure-onset time, and ictal HFOs discharged after that. Collectively, our results show that coupling of infraslow activities and HFOs precedes the seizure-onset time. We infer that such coupling may be a potential biomarker for seizure prediction.
- リンク情報
- ID情報
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- DOI : 10.1002/epi4.12425
- ISSN : 2470-9239
- eISSN : 2470-9239
- PubMed ID : 32913958
- PubMed Central 記事ID : PMC7469835