論文

査読有り 国際誌
2014年6月19日

The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy.

Immunity
  • Jayoung Choi
  • Sunmin Park
  • Scott B Biering
  • Elizabeth Selleck
  • Catherine Y Liu
  • Xin Zhang
  • Naonobu Fujita
  • Tatsuya Saitoh
  • Shizuo Akira
  • Tamotsu Yoshimori
  • L David Sibley
  • Seungmin Hwang
  • Herbert W Virgin
  • 全て表示

40
6
開始ページ
924
終了ページ
35
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.immuni.2014.05.006
出版者・発行元
CELL PRESS

Autophagy is a lysosomal degradation pathway that is important in cellular homeostasis. Prior work showed a key role for the autophagy related 5 (Atg5) in resistance to Toxoplasma gondii. Here we show that the cassette of autophagy proteins involved in the conjugation of microtubule-associated protein 1 light chain 3 (LC3) to phosphatidylethanolamine, including Atg7, Atg3, and the Atg12-Atg5-Atg16L1 complex play crucial roles in the control of T. gondii in vitro and in vivo. In contrast, pharmacologic modulation of the degradative autophagy pathway or genetic deletion of other essential autophagy genes had no substantial effects. Rather the conjugation system was required for targeting of LC3 and interferon-γ effectors onto the vacuolar membrane of T. gondii and its consequent disruption. These data suggest that the ubiquitin-like conjugation systems that reorganize intracellular membranes during canonical autophagy are necessary for proper targeting of immune effectors to the intracellular vacuole membranes utilized by pathogens.

リンク情報
DOI
https://doi.org/10.1016/j.immuni.2014.05.006
J-GLOBAL
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201702215841557477
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24931121
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107903
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000341440200014&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.immuni.2014.05.006
  • ISSN : 1074-7613
  • eISSN : 1097-4180
  • J-Global ID : 201702215841557477
  • PubMed ID : 24931121
  • PubMed Central 記事ID : PMC4107903
  • Web of Science ID : WOS:000341440200014

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