Hiroshi Nagase

J-GLOBAL         Last updated: Nov 22, 2019 at 09:59
 
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Name
Hiroshi Nagase
Nickname
hiropon
E-mail
nagase.hiroshi.gtu.tsukuba.ac.jp
Affiliation
University of Tsukuba
Section
International Institute for Integrative Sleep Medicine
Research funding number
70383651
ORCID ID
0000-0003-0428-3979

Research Areas

 
 

Awards & Honors

 
2015
Medicinal Chemistry Symposium Award, THE PHARMACEUTICAL SOCIETY OF JAPAN Division of Medicinal Chemistry
 
2014
The 14th Yamazaki-Teiichi Prize, Foundation for Promotion of Material Science and Technology of Japan
 
2013
The Invention Prize, Japan on the National Commendation of Invention, Japan Institute of Invention and Innovation
 
2013
Okochi Memorial Technology Prize, Okochi Memorial Foundation
 
2009
Drug-Discovery Science Award, Japan, The Pharmaceutical Society of Japan
 
2009
Synthetic Organic Chemistry Award, Japan, The Society of Synthetic Organic Chemistry
 
1998
平成9年度日本薬学会創薬科学賞, The Pharmaceutical Society of Japan
 
1997
Synthetic Organic Chemistry Award, Japan, The Society of Synthetic Organic Chemistry
 
1995
Okochi Memorial Technology Prize, Okochi Memorial Foundation
 
1997
Patent Attorney Award, Japan on the National Commendation of Invention, Japan Institute of Invention and Innovation
 

Published Papers

 
Yamada D, Yanagisawa S, Yoshizawa K, Yanagita S, Oka JI, Nagase H, Saitoh A
Neuropharmacology   160 107792   Dec 2019   [Refereed]
Nagase H, Saitoh A
Pharmacology & therapeutics   107427   Oct 2019   [Refereed]
Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H
Bioorganic & medicinal chemistry letters   29(18) 2655-2658   Sep 2019   [Refereed]
Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin R, Murakoshi N, Fujii S, Zhou X, Sugiyama F, Chen JF, Kumagai H, Nagase H, Lazarus M
Neuropharmacology   153 153   Jul 2019   [Refereed]
Yamamoto N, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H
Bioorganic & medicinal chemistry   27(8) 1747-1758   Apr 2019   [Refereed]
Sugiyama A, Yamada M, Furuie H, Gotoh L, Saitoh A, Nagase H, Oka JI, Yamada M
Journal of pharmacological sciences   139(3) 174-179   Mar 2019   [Refereed]
Yan Zhang, Tomoya Sugai, Takashi Yamamoto, Naoshi Yamamoto, Noriki Kutsumura, Yasuaki Einaga, Shigeru Nishiyama, Tsuyoshi Saitoh, Hiroshi Nagase
Wiley-VCH   6 4194-4198   Nov 2018   [Refereed]
Kutsumura Noriki, Okada Takahiro, Imaide Satomi, Fujii Hideaki, Nagase Hiroshi
SYNTHESIS-STUTTGART   50(21) 4263-4269   Nov 2018   [Refereed]
Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin R, Murakoshi N, Fujii S, Zhou X, Sugiyama F, Chen JF, Kumagai H, Nagase H, Lazarus M
Neuropharmacology   144 122-132   Oct 2018   [Refereed]
Sugiyama A, Yamada M, Saitoh A, Nagase H, Oka JI, Yamada M
Psychopharmacology   235(10) 2947-2955   Oct 2018   [Refereed]
Kutsumura Noriki, Nagase Hiroshi
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN   76(9) 914-921   Sep 2018   [Refereed]
Saitoh A, Soda A, Kayashima S, Yoshizawa K, Oka JI, Nagase H, Yamada M
Journal of pharmacological sciences   138(3) 176-183   Sep 2018   [Refereed]
Chen HJ, Ihara T, Yoshioka H, Itoyama E, Kitamura S, Nagase H, Murakami H, Hoshino Y, Murakami M, Tomonaga S, Matsui T, Funaba M
Journal of animal science   96(9) 3884-3896   Jun 2018   [Refereed]
Wang Y, Cao L, Lee CY, Matsuo T, Wu K, Asher G, Tang L, Saitoh T, Russell J, Klewe-Nebenius D, Wang L, Soya S, Hasegawa E, Chérasse Y, Zhou J, Li Y, Wang T, Zhan X, Miyoshi C, Irukayama Y, Cao J, Meeks JP, Gautron L, Wang Z, Sakurai K, Funato H, Sakurai T, Yanagisawa M, Nagase H, Kobayakawa R, Kobayakawa K, Beutler B, Liu Q
Nature communications   9(1) 2041   May 2018   [Refereed]
Toyama Satoshi, Shimoyama Naohito, Tagaito Yugo, Nagase Hiroshi, Saitoh Tsuyoshi, Yanagisawa Masashi, Shimoyama Megumi
ANESTHESIOLOGY   128(5) 992-1003   May 2018   [Refereed]
Toyama S, Shimoyama N, Tagaito Y, Nagase H, Saitoh T, Yanagisawa M, Shimoyama M
Anesthesiology   128(5) 992-1003   May 2018   [Refereed]
Saitoh A, Tominaga H, Ogawa Y, Irukayama-Tomobe Y, Yamada M, Yanagisawa M, Nagase H
Pharmacological reports : PR   70(2) 350-354   Apr 2018   [Refereed]
Kutsumura N, Koyama Y, Suzuki Y, Tominaga KI, Yamamoto N, Saitoh T, Nagumo Y, Nagase H
Organic letters   20(6) 1559-1562   Mar 2018   [Refereed]
Ohrui S, Yamamoto N, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H
Bioorganic & medicinal chemistry letters   28(4) 774-777   Feb 2018   [Refereed]
Saitoh A, Suzuki S, Soda A, Ohashi M, Yamada M, Oka JI, Nagase H, Yamada M
Behavioural brain research   336 77-84   Jan 2018   [Refereed]
Yamamoto Naoshi, Okada Takahiro, Harada Yukimasa, Kutsumura Noriki, Imaide Satomi, Saitoh Tsuyoshi, Fujii Hideaki, Nagase Hiroshi
TETRAHEDRON   73(39) 5751-5758   Sep 2017   [Refereed]
Fujii Hideaki, Shimada Naoyuki, Ohtawa Masaki, Karaki Fumika, Koshizuka Masayoshi, Hayashida Kohei, Kamimura Mitsuhiro, Makino Kazuishi, Nagamitsu Tohru, Nagase Hiroshi
TETRAHEDRON   73(36) 5425-5429   Sep 2017   [Refereed]
Yamamoto N, Ohrui S, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H
Bioorganic & medicinal chemistry letters   27(17) 4176-4179   Sep 2017   [Refereed]
Kutsumura Noriki, Ohshita Ryuichiro, Horiuchi Jumpei, Tateno Kotaro, Yamamoto Naoshi, Saitoh Tsuyoshi, Nagumo Yasuyuki, Kawai Hidetoshi, Nagase Hiroshi
TETRAHEDRON   73(34) 5214-5219   Aug 2017   [Refereed]
Kutsumura N, Koyama Y, Nagumo Y, Nakajima R, Miyata Y, Yamamoto N, Saitoh T, Yoshida N, Iwata S, Nagase H
Bioorganic & medicinal chemistry   25(16) 4375-4383   Aug 2017   [Refereed]
Watanabe Y, Hayashida K, Saito D, Takahashi T, Sakai J, Nakata E, Kanda T, Iwai T, Hirayama S, Fujii H, Yamakawa T, Nagase H
Bioorganic & medicinal chemistry letters   27(15) 3495-3498   Aug 2017   [Refereed]
Hayashida K, Hirayama S, Iwai T, Watanabe Y, Takahashi T, Sakai J, Nakata E, Yamakawa T, Fujii H, Nagase H
Bioorganic & medicinal chemistry letters   27(12) 2742-2745   Jun 2017   [Refereed]
Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M
Proceedings of the National Academy of Sciences of the United States of America   114(22) 5731-5736   May 2017   [Refereed]
Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL
Nature chemical biology   13(5) 529-536   May 2017   [Refereed]
Lansu Katherine, Karpiak Joel, Liu Jing, Huang Xi-Ping, McCorvy John D., Kroeze Wesley K., Che Tao, Nagase Hiroshi, Carroll Frank I., Jin Jian, Shoichet Brian K., Roth Bryan L.
NATURE CHEMICAL BIOLOGY   13(5) 529-+   May 2017   [Refereed]
Gotoh L, Saitoh A, Yamada M, Fujii H, Nagase H, Yamada M
Behavioural brain research   323 11-14   Apr 2017   [Refereed]
The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice
Saitoh Akiyoshi, Suzuki Satoshi, Ohashi Masanori, Soda Akinobu, Yamada Misa, Oka Jun-Ichiro, Nagase Hiroshi, Yamada Mitsuhiko
JOURNAL OF PHARMACOLOGICAL SCIENCES   133(3) S129   Mar 2017   [Refereed]
Transgenic overexpression of orexin improves survival after myocardial infarction in mice
Ishikawa Yui, Murakoshi Nobuyuki, Irukayama Yoko, Ogawa Yasuhiro, Uchida Shuntaro, Tominaga Hiromu, Tajiri Kazuko, Nagase Hiroshi, Yanagisawa Masashi
JOURNAL OF PHARMACOLOGICAL SCIENCES   133(3) S166   Mar 2017   [Refereed]
Histological and electrophysiological analysis of a small-molecule OX2R-slective agonist YNT-185
Ogawa Yasuhiro, Irukayama Yoko, Tominaga Hiromu, Hosokawa Naoto, Saito Tsuyoshi, Nagase Hiroshi, Yanagisawa Masashi
JOURNAL OF PHARMACOLOGICAL SCIENCES   133(3) S163   Mar 2017   [Refereed]
A small molecule orexin receptor agonist promotes recovery from inflammation-induced immobility
Uchida Shuntaro, Irukayama Yoko, Ogawa Yasuhiro, Tominaga Hiromu, Ishikawa Yui, Kiyama Maiko, Saito Tsuyoshi, Nagase Hiroshi, Yanagisawa Masashi
JOURNAL OF PHARMACOLOGICAL SCIENCES   133(3) S163   Mar 2017   [Refereed]
Nagase H, Yamamoto N, Yata M, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Hirayama S, Kuroda D, Watanabe Y, Gouda H, Yanagisawa M
Journal of medicinal chemistry   60(3) 1018-1040   Feb 2017   [Refereed]
Yajima Saki, Saitoh Tsuyoshi, Kawa Kohei, Nakamura Kensuke, Nagase Hiroshi, Einaga Yasuaki, Nishiyama Shigeru
TETRAHEDRON   72(51) 8428-8435   Dec 2016   [Refereed]
Kutsumura N, Koyama Y, Tateno K, Yamamoto N, Nagase H, Saito T
Chemical & pharmaceutical bulletin   64(9) 1364-1369   Sep 2016   [Refereed]
Hypothalamic opioid receptors control feeding behavior though orexin and GABA Neurons
Ikeda Hiroko, Ardianto Chrismawan, Yonemochi Naomi, Yamamoto Shogo, Yang Lizhe, Takenoya Fumiko, Shioda Seiji, Nagase Hiroshi, Kamei Junzo
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   19 303   Jun 2016   [Refereed]
Taniguchi S, Wang M, Ikeda S, Yoshioka H, Nagase H, Kitamura S, Itoyama E, Murakami H, Sugimoto M, Kume S
Animal science journal = Nihon chikusan Gakkaiho   87(4) 536-540   Apr 2016   [Refereed]
Orexin and GABA in the lateral hypothalamus play an important role in the regulation of feeding behavior by opioid systems
Ardianto Chrismawan, Ikeda Hiroko, Yonemochi Naomi, Yang Lizhe, Yamamoto Shogo, Ikegami Megumi, Takenoya Fumiko, Shioda Seiji, Nagase Hiroshi, Kamei Junzo
JOURNAL OF PHARMACOLOGICAL SCIENCES   130(3) S83   Mar 2016   [Refereed]
YNT-185, a novel small-molecule orexin type 2 receptor agonist, ameliorates narcolepsy-cataplexy symptoms in model mice
Tominaga Hiromu, Irukayama-Tomobe Yoko, Ogawa Yasuhiro, Lshikawa Yukiko, Hosokawa Naoto, Ambai Shinobu, Kawabe Yuki, Uchida Syuntaro, Saitoh Tsuyoshi, Nakajima Ryo, Nagase Hiroshi, Yanagisawa Masashi
JOURNAL OF PHARMACOLOGICAL SCIENCES   130(3) S138   Mar 2016   [Refereed]
Synthesis of a novel delta opioid receptor inverse agonist and its short-term memory improving effect under restraint stress in mice
Hirayama Shigeto, Higashi Eika, Iwai Takashi, Nakamura Minami, Nemoto Toru, Nagase Hiroshi, Tanabe Mitsuo, Fujii Hideaki
JOURNAL OF PHARMACOLOGICAL SCIENCES   130(3) S231   Mar 2016   [Refereed]
Peripheral antipruritic effect of nalfurafine
Otowa Akira, Mizoguchi Hirokazu, Watanabe Chizuko, Nagase Hiroshi, Sakurada Shinobu
JOURNAL OF PHARMACOLOGICAL SCIENCES   130(3) S175   Mar 2016   [Refereed]
Komatsu T, Katsuyama S, Nagase H, Mizoguchi H, Sakurada C, Tsuzuki M, Sakurada S, Sakurada T
Pharmacology, biochemistry, and behavior   140 68-74   Jan 2016   [Refereed]
Kutsumura N, Nakajima R, Koyama Y, Miyata Y, Saitoh T, Yamamoto N, Iwata S, Fujii H, Nagase H
Bioorganic & medicinal chemistry letters   25(21) 4890-4892   Nov 2015   [Refereed]
Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H
Journal of medicinal chemistry   58(20) 7931-7937   Oct 2015   [Refereed]
Nakajima R, Yamamoto N, Hirayama S, Iwai T, Saitoh A, Nagumo Y, Fujii H, Nagase H
Bioorganic & medicinal chemistry   23(19) 6271-6279   Oct 2015   [Refereed]
Nemoto T, Iihara Y, Hirayama S, Iwai T, Higashi E, Fujii H, Nagase H
Bioorganic & medicinal chemistry letters   25(15) 2927-2930   Aug 2015   [Refereed]
Effects of narcotic analgesics on the multiple sclerosis-related pain
Mizoguchi Hirokazu, Sumi Takahiro, Watanabe Chizuko, Ohtsuki Asuna, Nagase Hiroshi, Sakurada Shinobu
JOURNAL OF PHARMACOLOGICAL SCIENCES   128(3) S130   Jul 2015   [Refereed]
Convulsive effects of delta opioid receptor agonists are modulated by delta-arrestin signaling
Sakai Junichi, Nakata Eriko, Watanabe Yoshikazu, Saito Daisuke, Takahashi Toshihiro, Iwai Takashi, Hirayama Shigeto, Fujii Hideaki, Yamakawa Tomio, Nagase Hiroshi
JOURNAL OF PHARMACOLOGICAL SCIENCES   128(3) S232   Jul 2015   [Refereed]
A delta opioid receptor agonist KNT-127 as an appropriate therapeutic agent for anxiety disorder when combined with exposure therapy
Sugiyama Azusa, Saitoh Akiyoshi, Oka Jun-Ichiro, Nagase Hiroshi, Yamada Mitsuhiko
JOURNAL OF PHARMACOLOGICAL SCIENCES   128(3) S92   Jul 2015   [Refereed]
Design and synthesis of delta agonists
Nagase Hiroshi
JOURNAL OF PHARMACOLOGICAL SCIENCES   128(3) S65   Jul 2015   [Refereed]
Discovery of novel delta opioid receptor agonists without convulsive effects
Nakata Eriko, Sakai Junichi, Watanabe Yoshikazu, Saito Daisuke, Takahashi Toshihiro, Iwai Takashi, Hirayama Shigeto, Fujii Hideaki, Yamakawa Tomio, Nagase Hiroshi
JOURNAL OF PHARMACOLOGICAL SCIENCES   128(3) S66   Jul 2015   [Refereed]
Wang M, Ikeda S, Yoshioka H, Nagase H, Kitamura S, Itoyama E, Murakami H, Sugimoto M, Kume S
Animal science journal = Nihon chikusan Gakkaiho   86(7) 673-678   Jul 2015   [Refereed]
Nagase H, Kutsumura N
Archiv der Pharmazie   348(6) 375-389   Jun 2015   [Refereed]
Suzuki M, Chiwaki F, Sawada Y, Ashikawa M, Aoyagi K, Fujita T, Yanagihara K, Komatsu M, Narita M, Suzuki T, Nagase H, Kushima R, Sakamoto H, Fukagawa T, Katai H, Nakagama H, Yoshida T, Uezono Y, Sasaki H
PloS one   10(4) e0123407   Apr 2015   [Refereed]
Konoura K, Fujii H, Imaide S, Gouda H, Hirayama S, Hirono S, Nagase H
Bioorganic & medicinal chemistry   23(3) 439-448   Feb 2015   [Refereed]
Meet the editorial board.
Nagase H
Current topics in medicinal chemistry   15(5) 413   2015   [Refereed]
Hirayama S, Wada N, Kuroda N, Iwai T, Yamaotsu N, Hirono S, Fujii H, Nagase H
Bioorganic & medicinal chemistry letters   24(20) 4895-4898   Oct 2014   [Refereed]
Hirayama S, Wada N, Nemoto T, Iwai T, Fujii H, Nagase H
ACS medicinal chemistry letters   5(8) 868-872   Aug 2014   [Refereed]
Nagase H, Nakajima R, Yamamoto N, Hirayama S, Iwai T, Nemoto T, Gouda H, Hirono S, Fujii H
Bioorganic & medicinal chemistry letters   24(13) 2851-2854   Jul 2014   [Refereed]
Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE
Neuron   82(3) 573-586   May 2014   [Refereed]
Fujii H, Hayashida K, Saitoh A, Yokoyama A, Hirayama S, Iwai T, Nakata E, Nemoto T, Sudo Y, Uezono Y, Yamada M, Nagase H
ACS medicinal chemistry letters   5(4) 368-372   Apr 2014   [Refereed]
Sugiyama A, Nagase H, Oka J, Yamada M, Saitoh A
Neuropharmacology   79 314-320   Apr 2014   [Refereed]
Ishikawa Kyoko, Tomatsu Miyuki, Nagase Hiroshi, Fujii Hideaki
HETEROCYCLES   88(2) 1051-1063   Jan 2014   [Refereed]
PROCEEDINGS OF THE 22ND INTERNATIONAL CONFERENCE ON NUCLEAR ENGINEERING - 2014, VOL 1      2014   [Refereed]
Nagase Hiroshi, Nagura Makoto
COMMUNICATIONS IN ALGEBRA   42(10) 4561-4577   2014   [Refereed]
Antipruritic effect of kappa-opioid receptor agonist in mice
Niida Takahiro, Mizoguchi Hirokazu, Watanabe Chizuko, Yonezawa Akihiko, Nagase Hiroshi, Sakurada Shinobu
JOURNAL OF PHARMACOLOGICAL SCIENCES   124 189P   2014   [Refereed]
The antinociceptive effect of opioid analgesics in neuropathic cancer pain
Sugawara Ryou, Mizoguchi Hirokazu, Watanabe Chizuko, Yonezawa Akihiko, Kanno Syu-ichi, Ishikawa Masaaki, Nagase Hiroshi, Sakurada Shinobu
JOURNAL OF PHARMACOLOGICAL SCIENCES   124 154P   2014   [Refereed]
The possible involvement of hypothalamic peptides in feeding regulation by opioid systems
Ardianto Chrismawan, Ikeda Hiroko, Yang Lizhe, Ikegami Megumi, Nagase Hiroshi, Kamei Junzo
JOURNAL OF PHARMACOLOGICAL SCIENCES   124 84P   2014   [Refereed]
Nemoto T, Ida Y, Iihara Y, Nakajima R, Hirayama S, Iwai T, Fujii H, Nagase H
Bioorganic & medicinal chemistry   21(24) 7628-7647   Dec 2013   [Refereed]
Nagase Hiroshi, Fujii Hideaki
CURRENT PHARMACEUTICAL DESIGN   19(42) 7400-7414   Dec 2013   [Refereed]
Yamamizu K, Furuta S, Hamada Y, Yamashita A, Kuzumaki N, Narita M, Doi K, Katayama S, Nagase H, Yamashita JK, Narita M
Scientific reports   3 3213   Nov 2013   [Refereed]
Fujii H, Takahashi T, Nagase H
Expert opinion on therapeutic patents   23(9) 1181-1208   Sep 2013   [Refereed]
Watanabe Y, Kitazawa S, Nemoto T, Hirayama S, Iwai T, Fujii H, Nagase H
Bioorganic & medicinal chemistry   21(11) 3032-3050   Jun 2013   [Refereed]
Saitoh A, Sugiyama A, Yamada M, Inagaki M, Oka J, Nagase H, Yamada M
Neuropharmacology   67 485-493   Apr 2013   [Refereed]
Ise Y, Mori T, Katayama S, Nagase H, Suzuki T
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   80(1) 34-41   Feb 2013   [Refereed]
Nemoto T, Yamamoto N, Wada N, Harada Y, Tomatsu M, Ishihara M, Hirayama S, Iwai T, Fujii H, Nagase H
Bioorganic & medicinal chemistry letters   23(1) 268-272   Jan 2013   [Refereed]
Nagase H, Fujii H
Current pharmaceutical design   19(42) 7400-7414   2013   [Refereed]
DYNORPHIN IS A NEUROMODULATOR REGULATING ITCH IN THE DORSAL HORN OF THE SPINAL CORD
Kardon Adam, Beresford-Polgar Erika, Hachisuka Junichi, McClement Lindsey, Hemenway Gregory, Fan Chris, Nagase Hiroshi, Todd Andrew, Ross Sarah
ACTA DERMATO-VENEREOLOGICA   93(5) 637   2013   [Refereed]
Development and screening of novel delta opioid receptor-specific agonists with a label-free, cell-impedance-based CellKey(TM) system
Yokoyama Akinobu, Sudo Yuka, Miyano Kanako, Suzuki Masami, Shiraishi Seiji, Hirayama Shigeto, Hayashida Kohei, Fujii Hideaki, Sakai Junichi, Kanda Takashi, Nakata Eriko, Nagase Hiroshi, Higami Yoshikazu, Uezono Yasuhito
JOURNAL OF PHARMACOLOGICAL SCIENCES   121 174P   2013   [Refereed]
The delta opioid receptor agonist KNT-127 produces distinct anxiolytic-like effects in rats without producing the adverse effects associated with benzodiazepines
Sugiyama Azusa, Saitoh Akiyoshi, Makino Yuya, Yamada Misa, Inagaki Masatoshi, Oka Jun-Ichiro, Nagase Hiroshi, Yamada Mitsuhiko
JOURNAL OF PHARMACOLOGICAL SCIENCES   121 75P   2013   [Refereed]
The involvement of hypothalamic and mesolimbic opioid systems in regulating food intake
Ardianto Chrismawan, Ikeda Hiroko, Ohashi Takahiro, Ikegami Megumi, Nagase Hiroshi, Kamei Junzo
JOURNAL OF PHARMACOLOGICAL SCIENCES   121 65P   2013   [Refereed]
Wada N, Fujii H, Koyano K, Hirayama S, Iwai T, Nemoto T, Nagase H
Bioorganic & medicinal chemistry letters   22(24) 7551-7554   Dec 2012   [Refereed]
Fujii H, Nakajima R, Akiyama J, Yamamoto N, Hirayama S, Nemoto T, Gouda H, Hirono S, Nagase H
Bioorganic & medicinal chemistry letters   22(24) 7697-7701   Dec 2012   [Refereed]
Fujii H, Imaide S, Hirayama S, Nemoto T, Gouda H, Hirono S, Nagase H
Bioorganic & medicinal chemistry letters   22(24) 7711-7714   Dec 2012   [Refereed]
Fujii Hideaki, Yamada Takaaki, Hayashida Kohei, Kuwada Miki, Hamasaki Atom, Nobuhara Kazunori, Ozeki Sumio, Nagase Hiroshi
HETEROCYCLES   85(11) 2685-2691   Nov 2012   [Refereed]
Ida Y, Matsubara A, Nemoto T, Saito M, Hirayama S, Fujii H, Nagase H
Bioorganic & medicinal chemistry   20(19) 5810-5831   Oct 2012   [Refereed]
Miyata Y, Fujii H, Uenohara Y, Kobayashi S, Takeuchi T, Nagase H
Bioorganic & medicinal chemistry letters   22(16) 5174-5176   Aug 2012   [Refereed]
Nagase Hiroshi, Fujii Hideaki
HETEROCYCLES   85(8) 1821-1867   Aug 2012   [Refereed]
Nagase H, Imaide S, Hirayama S, Nemoto T, Fujii H
Bioorganic & medicinal chemistry letters   22(15) 5071-5074   Aug 2012   [Refereed]
Nagase Hiroshi, Imaide Satomi, Yamada Takaaki, Hirayama Shigeto, Nemoto Toru, Yamaotsu Noriyuki, Hirono Shuichi, Fujii Hideaki
CHEMICAL & PHARMACEUTICAL BULLETIN   60(8) 945-948   Aug 2012   [Refereed]
Role of Opioid Receptors in Regulating Feeding Behavior of Mice
Ikeda Hiroko, Ardianto Chrismawan, Ohashi Takahiro, Asato Megumi, Nagase Hiroshi, Kamei Junzo
DIABETES   61 A497   Jun 2012   [Refereed]
Enomoto T, Yamashita A, Torigoe K, Horiuchi H, Hirayama S, Nakahara K, Yanase M, Sakai H, Ikegami D, Nagase H, Suzuki T, Iseki M, Inada E, Narita M
Synapse (New York, N.Y.)   66(6) 483-488   Jun 2012   [Refereed]
Nagase H, Akiyama J, Nakajima R, Hirayama S, Nemoto T, Gouda H, Hirono S, Fujii H
Bioorganic & medicinal chemistry letters   22(8) 2775-2779   Apr 2012   [Refereed]
Watanabe Y, Kitazawa S, Fujii H, Nemoto T, Hirayama S, Nagase H
Bioorganic & medicinal chemistry letters   22(8) 2689-2692   Apr 2012   [Refereed]
Tanahashi S, Ueda Y, Nakajima A, Yamamura S, Nagase H, Okada M
Neuropharmacology   62(5-6) 2057-2067   Apr 2012   [Refereed]
Ida Y, Nemoto T, Hirayama S, Fujii H, Osa Y, Imai M, Nakamura T, Kanemasa T, Kato A, Nagase H
Bioorganic & medicinal chemistry   20(2) 949-961   Jan 2012   [Refereed]

Conference Activities & Talks

 
Design and Synthesis of Orexin Receptor Selective Ligands [Invited]
Hiroshi Nagase
26th French-Japanese Symposium on Medicinal & Fine Chemistry   18 Sep 2017   
Design and Synthesis of Nalfurafine for an Antipruritic Drug for Chronic liver Disease Patients and kidney Dialysis Patients [Invited]
Hiroshi Nagase
The 12th JSH Single Topic Conference   23 Sep 2016   
Design and Synthesis of Orexin 2 Receptor Agonists [Invited]
Hiroshi Nagase
Tsukuba Global Science Week 2016   19 Sep 2016   
The science and the development of non-addictive opioid receptor agonists [Invited]
Hiroshi Nagase
FIP World Congress of Pharmacy and Pharmaceutical Sciences   30 Aug 2016   
Design and Synthesis of OX2R selective agonists and their pharmacologies [Invited]
Hiroshi Nagase
Brain/Liver interface medicine research center symposium   7 Mar 2016   
Design and synthesis of novel ligands of opioid receptors [Invited]
Hiroshi Nagase
Pacifichem 2015   17 Dec 2015   
Study and Development of Opioid κ Agonist, Nalfurafine and their Clinical Effects [Invited]
Hiroshi Nagase
Temple University   27 Jul 2015   
DESIGN AND SYNTHESIS OF NOVEL δ OPIOID AGONISTS AND THEIR PHARMACOLOGIES [Invited]
Hiroshi Nagase
Drug Discovery & Therapy World Congress 2015   23 Jul 2015   
Study and development of opioid κ agonist, nalfurafine and their clinical effects [Invited]
Hiroshi Nagase
21 Feb 2015   
Synthesis of a novel opioid receptor agonist, SYK-146 with 1,3,5-trioxazatriquinane skeleton and its pharmacologies [Invited]
Hiroshi Nagase
DPhG Jahrestagung 2014   25 Sep 2014   
design and synthesis of novel ligands for opioid receptors [Invited]
Hiroshi Nagase
5 Sep 2014   
Design and Synthesis of Opioid Receptor Type Selective Ligands [Invited]
Hiroshi Nagase
University of Minnesota   10 Jun 2014   
Synthesis of Novel Triplets with 1,3,5-Trioxazatriquinane Skeleton Using Nitrogen Clamp [Invited]
Hiroshi Nagase
The 2nd HBP Symposium at Tsukuba Global Science Week 2013   2 Oct 2013   

Research Grants & Projects

 
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Jul 2015 - Mar 2020    Investigator(s): Hiroshi Nagase
Japan Agency for Medical Research and Development 医療研究開発革新基盤創成事業(CiCLE:Cyclic Innovation: Cyclic Innovation for Clinical Empowerment
Project Year: Apr 2018 - Mar 2022    Investigator(s): Hiroshi Nagase
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2016 - Mar 2019    Investigator(s): Hiroshi Nagase
Japan Agency for Medical Research and Development: Acceleration Transformative Research for Medical Innovation
Project Year: Apr 2016 - Mar 2018    Investigator(s): Hiroshi Nagase
Japan Agency for Medical Research and Development: Acceleration Transformative Research for Medical Innovation
Project Year: Oct 2015 - Mar 2016    Investigator(s): Hiroshi Nagase
Japan Agency for Medical Research and Development: Medical Research and Development Programs Focused on Technology Transfer: Adaptable and Seamless Technology Transfer Program through Target-Driven Research and Development (AMED・A-STEP)
Project Year: Apr 2015 - Dec 2015    Investigator(s): Hiroshi Nagase
Japan Science and Technology Agency: A-STEP (Adaptable and Seamless Technology Transfer Program through Target-driven R&D)
Project Year: Apr 2014 - Mar 2015    Investigator(s): Hiroshi Nagase