ナジアブデラヒム (Naji Abderrahim) - マイポータル

基本情報

所属: Kochi University Tenured Lecturer

学位: PhD(University Paris 7 Denis Diderot)

J-GLOBAL ID: 201901013452398923
researchmap会員ID: B000379429

I am an Immunologist and Cell Biologist. I am interested in sterile and non-sterile inflammation, immunosuppression and cell death in diseases. Especially, I am interested in inflammatory diseases induced by nanoparticles, crystals and fibers. I am also interested in cancer including lymphoma, melanoma and gastric cancer. Also, my work is directed to study Mesenchymal Stem Cell (MSC) biological functions. Particularly, the biological functions of MSCs for immunosuppression and cell death modulation in cell therapy.

研究キーワード

研究分野

論文

Single-cell RNA sequencing of human non-hematopoietic bone marrow cells reveals a unique set of inter-species conserved biomarkers for native mesenchymal stromal cells.

Loïc Fiévet, Nicolas Espagnolle, Daniela Gerovska, David Bernard, Charlotte Syrykh, Camille Laurent, Pierre Layrolle, Julien De Lima, Arthur Justo, Nicolas Reina …

Stem cell research & therapy 14(1) 229-229 2023年8月30日
Leukocyte Immunoglobulin-Like Receptors in Regulating the Immune Response in Infectious Diseases: A Window of Opportunity to Pathogen Persistence and a Sound Target in Therapeutics

Florence Abdallah, Sixtine Coindre, Margaux Gardet, Florian Meurisse, Abderrahim Naji, Narufumi Suganuma, Laurent Abi-Rached, Olivier Lambotte, Benoit Favier

Frontiers in Immunology 12 2021年9月14日
Cell immaturity and white/beige adipocyte‐potential of primary human adipose‐derived stromal cells are restrained by culture‐medium TGFβ1

Hélène Leménager, Loïc M.A. Fiévet, Fabien Guilloton, Abderrahim Naji et al.

Stem Cells 2020年2月査読有り
Biological functions of mesenchymal stem cells and clinical implications

ナジ・アブデラヒム

Cellular and Molecular Life Sciences 76(17) 3323-3348 2019年9月査読有り
Mesenchymal stem/stromal cell function in modulating cell death

ナジ・アブデラヒム

Stem Cell Research & Therapy 10(56) 2019年2月査読有り
Rationale for Determining the Functional Potency of Mesenchymal Stem Cells in Preventing Regulated Cell Death for Therapeutic Use

Abderrahim Naji, Narufumi Suganuma, Nicolas Espagnolle, Ken-ichi Yagyu, Nobuyasu Baba, Luc Sense, Frederic Deschaseaux

STEM CELLS TRANSLATIONAL MEDICINE 6(3) 713-719 2017年3月査読有り
Endocytosis of indium-tin-oxide nanoparticles by macrophages provokes pyroptosis requiring NLRP3-ASC-Caspase1 axis that can be prevented by mesenchymal stem cells

Abderrahim Naji, Basilua Andre Muzembo, Ken-ichi Yagyu, Nobuyasu Baba, Frederic Deschaseaux, Luc Sensebe, Narufumi Suganuma

SCIENTIFIC REPORTS 6(26162) 2016年5月査読有り
Binding of HLA-G to ITIM-Bearing Ig-like Transcript 2 Receptor Suppresses B Cell Responses

Abderrahim Naji, Catherine Menier, Fabio Morandi, Sophie Agaugue, Guitta Maki, Elisa Ferretti, Sylvie Bruel, Vito Pistoia, Edgardo D. Carosella, Nathalie Rouas-Freiss

JOURNAL OF IMMUNOLOGY 192(4) 1536-1546 2014年2月査読有り
Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue

Frederic Deschaseaux, Julien Gaillard, Alain Langonne, Christophe Chauveau, Abderrahim Naji, Amina Bouacida, Philippe Rosset, Dominique Heymann, Gonzague De Pinieux, Nathalie Rouas-Freiss …

FASEB JOURNAL 27(8) 2977-2987 2013年8月査読有り
Neoplastic B-cell growth is impaired by HLA-G/ILT2 interaction

ナジ・アブデラヒム

Leukemia 26 1889-1892 2012年5月査読有り
Dendritic Cells Secrete the Immunosuppressive HLA-G Molecule upon CTLA4-Ig Treatment: Implication in Human Renal Transplant Acceptance

Rajia Bahri, Abderrahim Naji, Catherine Menier, Bernard Charpentier, Edgardo D. Carosella, Nathalie Rouas-Freiss, Antoine Durrbach

JOURNAL OF IMMUNOLOGY 183(11) 7054-7062 2009年12月査読有り
HLA-G is a Crucial Immunosuppressive Molecule Secreted by Adult Human Mesenchymal Stem Cells

Zohair Selmani, Abderrahim Naji, Emilie Gaiffe, Laurent Obert, Pierre Tiberghien, Nathalie Rouas-Freiss, Edgardo D. Carosella, Frederic Deschaseaux

TRANSPLANTATION 87(9) S62-S66 2009年5月査読有り
Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4(+)CD25(high)FOXP3(+) regulatory T cells

Zohair Selmani, Abderrahim Naji, Ines Zidi, Benoit Favier, Emilie Gaiffe, Laurent Obert, Christophe Borg, Philippe Saas, Pierre Tiberghien, Nathalie Rouas-Freiss …

STEM CELLS 26(1) 212-222 2008年査読有り
Tolerogenic functions of human leukocyte antigen G: From pregnancy to organ and cell transplantation

Nathalie Rouas-Freiss, Abderrahim Naji, Antoine Durrbach, Edgardo D. Carosella

TRANSPLANTATION 84(1) S21-S25 2007年7月査読有り
Soluble HLA-G and HLA-G1 expressing antigen-presenting cells inhibit T-cell alloproliferation through ILT-2/ILT-4/FasL-mediated pathways

Abderrahim Naji, Antoine Durrbach, Edgardo D. Carosella, Nathalie Rouas-Freiss

HUMAN IMMUNOLOGY 68(4) 233-239 2007年4月査読有り

MISC

Concise Review: Combining Human Leukocyte Antigen G and Mesenchymal Stem Cells for Immunosuppressant Biotherapy

Abderrahim Naji, Nathalie Rouas-Freiss, Antoine Durrbach, Edgardo D. Carosella, Luc Sensebe, Frederic Deschaseaux

STEM CELLS 31(11) 2296-2303 2013年11月
Human mesenchymal stem cells induce immunosuppression through HLA-G expression

Abderrahim Naji, Zohair Selmani, Ines Zidi, Benoit Favier, Laurent Ober, Patricia Ame-Thomas, Christophe Borg, Nathalie Rouas-Freiss, Pierre Tiberghien, Edgardo Carosella …

TRANSPLANT INTERNATIONAL 20 149-149 2007年9月

共同研究・競争的資金等の研究課題

Mesenchymal stem cell function to prevent regulated cell death

日本学術振興会科学研究費助成事業若手研究(B) 2017年4月 - 2019年3月

NAJI ABDERRAHIM