論文

国際誌
2021年3月1日

Dosimetric effect of the intestinal gas of online adaptive stereotactic body radiotherapy on target and critical organs without online electron density correction for pancreatic cancer.

The British journal of radiology
  • Chen Su
  • ,
  • Hiroyuki Okamoto
  • ,
  • Shie Nishioka
  • ,
  • Tatsuya Sakasai
  • ,
  • Daisuke Fujiyama
  • ,
  • Yuki Miura
  • ,
  • Yuki Tsunoda
  • ,
  • Junichi Kuwahara
  • ,
  • Satoshi Nakamura
  • ,
  • Kotaro Iijima
  • ,
  • Takahito Chiba
  • ,
  • Keita Kaga
  • ,
  • Mihiro Takemori
  • ,
  • Hiroki Nakayama
  • ,
  • Shouichi Katsuta
  • ,
  • Koji Inaba
  • ,
  • Hiroshi Igaki
  • ,
  • Yuko Nakayama
  • ,
  • Jun Itami

94
1119
開始ページ
20200239
終了ページ
20200239
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1259/bjr.20200239

OBJECTIVE: This study aimed to assess the dosimetric effect of intestinal gas of stereotactic magnetic resonance (MR)-guided adaptive radiation therapy (SMART) on target and critical organs for pancreatic cancer without online electron density correction (EDC). METHODS: Thirty pancreatic cancer patients who underwent online SMART were selected for this study. The treatment time of each stage and the total treatment time were recorded and analyzed. The concerned dose-volume parameters of target and organs-at-risk (OAR) were compared with and without an intestinal gas EDC using the Wilcoxon-signed rank test. Analysis items with p value < 0.05 were considered statistically significant. The relationships between dosimetric differences and intestinal gas volume variations were investigated using the Spearman test. RESULTS: The average treatment time was 82 min, and the average EDC time was 8 min, which accounted for 10% of the overall treatment time. There were no significant differences in CTV (GTV), PTV, bowel, stomach, duodenum, and skin (p > 0.05) with respect to dose volume parameters. For the Dmax of gastrointestinal organs (p = 0.03), the mean dose of the liver (p = 0.002) and kidneys (p = 0.03 and p = 0.04 for the left and right kidneys, respectively), there may be a risk of slight overestimation compared with EDC, and for the Dmax of the spinal cord (p = 0.02), there may be a risk of slight underestimation compared with EDC. A weak correlation for D95 in the PTV and D0.5 cc in the duodenum was observed. CONCLUSION: For patients with similar inter-fractional intestinal gas distribution, EDC had little dosimetric effects on the D0.5 cc of all GI organs and dose volume parameters of target in most plans. ADVANCES IN KNOWLEDGE: By omitting the EDC of intestinal gas, the online SMART treatment time can be shortened.

リンク情報
DOI
https://doi.org/10.1259/bjr.20200239
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33353402

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