論文

国際誌
2020年12月14日

The use of hyperbaric oxygen to treat actinic rectal fistula after SpaceOAR use and radiotherapy for prostate cancer: a case report.

BMC urology
  • Tairo Kashihara
  • ,
  • Koji Inaba
  • ,
  • Motokiyo Komiyama
  • ,
  • Hiroki Nakayama
  • ,
  • Kotaro Iijima
  • ,
  • Shie Nishioka
  • ,
  • Hiroyuki Okamoto
  • ,
  • Nao Kikkawa
  • ,
  • Yuko Kubo
  • ,
  • Satoshi Shima
  • ,
  • Satoshi Nakamura
  • ,
  • Ayaka Takahashi
  • ,
  • Kana Takahashi
  • ,
  • Kae Okuma
  • ,
  • Naoya Murakami
  • ,
  • Hiroshi Igaki
  • ,
  • Yuko Nakayama
  • ,
  • Arinobu Fukunaga
  • ,
  • Yoshiyuki Matsui
  • ,
  • Hiroyuki Fujimoto
  • ,
  • Jun Itami

20
1
開始ページ
196
終了ページ
196
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s12894-020-00767-3
出版者・発行元
BMC

BACKGROUND: In definitive radiation therapy for prostate cancer, the SpaceOAR® System, a hydrogel spacer, is widely used to decrease the irradiated dose and toxicity of rectum. On the other hand, periprostatic abscesses formation and rectal perforation are known as rare adverse effects of SpaceOAR. Nevertheless, there is a lack of reports clarifying the association between aggravation of abscesses and radiation therapy, and hyperbaric oxygen therapy (HBOT) is effective for a peri-SpaceOAR abscess and rectal perforation. CASE PRESENTATION: We report a case of a 78-year-old high-risk prostate cancer patient. After SpaceOAR insertion into the correct space, he started to receive external beam radiation therapy (EBRT). He developed a fever, perineal pain and frequent urination after the completion of EBRT, and the magnetic resonance imaging (MRI) revealed a peri-SpaceOAR abscess. Scheduled brachytherapy was postponed, administration of antibiotics and opioid via intravenous drip was commenced, and transperineal drainage was performed. After the alleviation of the abscess, additional EBRT instead of brachytherapy was performed with MRI-guided radiation therapy (MRgRT). On the last day of the MRgRT, perineal pain reoccurred, and MRI and colonoscopy detected the rectal perforation. He received an intravenous antibiotics drip and HBOT, and fully recovered from the rectal perforation. CONCLUSIONS: Our report indicates that EBRT can lead to a severe rectum complication by causing inflammation for patients with a peri-SpaceOAR abscess. Furthermore, HBOT was effective for the peri-SpaceOAR abscess and rectal perforation associated with EBRT.


リンク情報
DOI
https://doi.org/10.1186/s12894-020-00767-3
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33317509
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737272
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000599848800001&DestApp=WOS_CPL

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