2022年2月
Optogenetic stimulus-triggered acquisition of seizure resistance
NEUROBIOLOGY OF DISEASE
- 巻
- 163
- 号
- 開始ページ
- 105602
- 終了ページ
- 105602
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.nbd.2021.105602
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Unlike an electrical circuit, the hardware of the brain is susceptible to change. Repeated electrical brain stimulation mimics epileptogenesis. After such "kindling" process, a moderate stimulus would become sufficient in triggering a severe seizure. Here, we report that optogenetic neuronal stimulation can also convert the rat brain to a hyperexcitable state. However, continued stimulation once again converted the brain to a state that was strongly resistant to seizure induction. Histochemical examinations showed that moderate astrocyte activation was coincident with resilience acquisition. Administration of an adenosine A1 receptor antagonist instantly reverted the brain back to a hyperexcitable state, suggesting that hyperexcitability was suppressed by adenosine. Furthermore, an increase in basal adenosine was confirmed using in vivo microdialysis. Daily neuron-to-astrocyte signaling likely prompted a homeostatic increase in the endogenous actions of adenosine. Our data suggest that a certain stimulation paradigm could convert the brain circuit resilient to epilepsy without exogenous drug administration.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.nbd.2021.105602
- ISSN : 0969-9961
- eISSN : 1095-953X
- PubMed ID : 34954320
- Web of Science ID : WOS:000820448600005