論文

査読有り
2013年4月

A Peptide Nucleic Acid (PNA) Heteroduplex Probe Containing an Inosine-Cytosine Base Pair Discriminates a Single-Nucleotide Difference in RNA

CHEMISTRY-A EUROPEAN JOURNAL
  • Katsuhiko Matsumoto
  • ,
  • Eiji Nakata
  • ,
  • Tomoki Tamura
  • ,
  • Isao Saito
  • ,
  • Yasunori Aizawa
  • ,
  • Takashi Morii

19
16
開始ページ
5034
終了ページ
5040
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/chem.201204183
出版者・発行元
WILEY-V C H VERLAG GMBH

Selective discrimination of a single-nucleotide difference in single-stranded DNA or RNA remains a challenge with conventional DNA or RNA probes. A peptide nucleic acid (PNA)-derived probe, in which PNA forms a pseudocomplementary heteroduplex with inosine-containing DNA or RNA, effectively discriminates a single-nucleotide difference in a closely related group of sequences of single-stranded DNA and/or RNA. The pseudocomplementary PNA heteroduplex is easily converted to a fluorescent probe that distinctively detects a member of highly homologous let-7 microRNAs.

リンク情報
DOI
https://doi.org/10.1002/chem.201204183
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23494894
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000317399600013&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/chem.201204183
  • ISSN : 0947-6539
  • PubMed ID : 23494894
  • Web of Science ID : WOS:000317399600013

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