The molecular mechanisms of the pathogenesis of autism spectrum disorders are largely unknown. To date, the certain molecular etiology has not been identified that can explain a large number of patients with autism spectrum disorders. The aim of this study was to analyze the neuronal functions involved in the control of social behavior and to identify the neural circuits that regulate social behavior. During the study period, the following results were identified. (1) We found that oxytocin restores abnormal social behavior in POGZ mutant mice, a mouse model of autism spectrum disorder. 2) We found that POGZ binds to the promoter of the oxytocin receptor gene and regulates its expression. (3) We found that the activity of anterior cingulate cortex neurons activated by social activities is important for the regulation of social behavior in mice.