論文

本文へのリンクあり 国際誌
2020年3月19日

Increased hydrostatic pressure induces nuclear translocation of DAF-16/FOXO in C. elegans.

Biochemical and biophysical research communications
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回数 : 47
  • Naoshi Watanabe
  • ,
  • Masatoshi Morimatsu
  • ,
  • Ayano Fujita
  • ,
  • Mika Teranishi
  • ,
  • Surabhi Sudevan
  • ,
  • Masaru Watanabe
  • ,
  • Hiroaki Iwasa
  • ,
  • Yutaka Hata
  • ,
  • Hiroyuki Kagi
  • ,
  • Masayoshi Nishiyama
  • ,
  • Keiji Naruse
  • ,
  • Atsushi Higashitani

523
4
開始ページ
853
終了ページ
858
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2020.01.047

Mechanical stimulation is well known to be important for maintaining tissue and organ homeostasis. Here, we found that hydrostatic pressure induced nuclear translocation of a forkhead box O (FOXO) transcription factor DAF-16, in C. elegans within minutes, whereas the removal of this pressure resulted in immediate export of DAF-16 to the cytoplasm. We also monitored DAF-16-dependent transcriptional changes by exposure to 1 MPa pressure for 5 min, and found significant changes in collagen and other genes in a DAF-16 dependent manner. Lifespan was markedly prolonged with exposure to cyclic pressure treatment (1 MPa once a day for 5 min from L1 larvae until death). Furthermore, age-dependent decline in locomotor activity was suppressed by the treatment. In contrast, the nuclear translocation of the yes-associated protein YAP-1 was not induced under the same pressure conditions. Thus, moderate hydrostatic pressure improves ageing progression through activation of DAF-16/FOXO in C. elegans.

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2020.01.047
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31954516

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