Papers

Peer-reviewed
Aug, 1997

Inhibition of multiplication of Mycobacterium leprae in mouse foot pads by immunization with ribosomal fraction and culture filtrate from Mycobacterium bovis BCG

VACCINE
  • M Matsuoka
  • ,
  • H Nomaguchi
  • ,
  • H Yukitake
  • ,
  • N Ohara
  • ,
  • S Matsumoto
  • ,
  • K Mise
  • ,
  • T Yamada

Volume
15
Number
11
First page
1214
Last page
1217
Language
English
Publishing type
Research paper (scientific journal)
Publisher
ELSEVIER SCI LTD

Immunization of mice with the ribosomal fraction from ruptured Mycobacterium bovis Bacillus Calmette-Guerin (BCG) and the culture filtrate reduced remarkably the multiplication of Mycobacterium leprae in the foot pads of mice, This is the first reported case of the protective activity against M, leprae multiplication in mice of the BCG ribosomal fraction and culture filtrate. The inhibition was more evident with the culture filtrate than with the ribosomal fraction. When the ribosomal proteins separated from ribosomal RNA were injected into mice, only slight inhibition was observed Ribosomal RNA alone did not inhibit at all, in contrast to the conclusion reported by Youmans and Youmans. (C) 1997 Elsevier Science Ltd.

Link information
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/9286046
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1997XT69200008&DestApp=WOS_CPL
ID information
  • ISSN : 0264-410X
  • Pubmed ID : 9286046
  • Web of Science ID : WOS:A1997XT69200008

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