Naoki Okamoto

Profile Information

Affiliation: Associate Professor, Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba

Degree: Doctor of Science(Mar, 2009, Nagoya University)

Researcher number: 10577969
J-GLOBAL ID: 202001007317347155
researchmap Member ID: R000005125

Research Interests

Research Areas

Research History

Jun, 2023 - Present

Associate Professor, Life Science Center for Survival Dynamics, TARA, University of Tsukuba
Apr, 2020 - May, 2023

Assistant Professor, Life Science Center for Survival Dynamics, University of Tsukuba
Sep, 2017 - Mar, 2020

Assistant Project Scientist, Department of Entomology, University of California, Riverside
Sep, 2015 - Aug, 2017

JSPS Postdoctoral fellow for Research Abroad / Assistant Project Scientist, Department of Entomology, University of California, Riverside
Apr, 2014 - Aug, 2015

Research Scientist, RIKEN Center for Developmental Biology, RIKEN
Apr, 2011 - Mar, 2014

Special Postdoctoral Researcher, RIKEN Center for Developmental Biology, RIKEN
Mar, 2010 - Mar, 2011

Research Scientist, RIKEN Center for Developmental Biology, RIKEN
Apr, 2009 - Mar, 2010

Global COE Prefellow, Graduate School of Bioagricultural Sciences, Nagoya University

Education

Apr, 2006 - Mar, 2009

Division of Biological Science, Graduate School of Science, Nagoya University
Apr, 2004 - Mar, 2006

Division of Biological Science, Graduate School of Science, Nagoya University
Apr, 2000 - Mar, 2004

Department of Biotechnology, Faculty of Engineering, Kansai University

Awards

Feb, 2023

2022 BEST FACULTY MEMBER, University of Tsukuba
Apr, 2021

令和3年度若手教員特別奨励賞
Apr, 2021

Young Scientists’ Prize for Science and Technology by Ministry of Education, Culture, Sports, Science and Technology
Jul, 2019

Excellent Oral Presentation Award (The 4th International Insect Hormone Workshop 2019), International Insect Hormone Workshop

Naoki Okamoto
Sep, 2017

Excellent Oral Presentation Award (The 3rd International Insect Hormone Workshop 2017), International Insect Hormone Workshop

Naoki Okamoto
Jul, 2015

Travel Award for Outstanding Oral Presentation (The 2nd International Insect Hormone Workshop 2015), International Insect Hormone Workshop

Naoki Okamoto
Jun, 2014

7th Daigoro Moriwaki Award : First Prize, The Japanese Drosophila Research Conference

Naoki Okamoto
Mar, 2014

Genetics Society of America Poster Award : Third Prize, Genetics Society of America

Naoki Okamoto
Jan, 2014

Biology Prize (FY2013: RIKEN Special Postdoctoral Researchers/Foreign Postdoctoral Researchers Presentation of Research Results), RIKEN

Naoki Okamoto
Mar, 2013

RIKEN Research Incentive Award, RIKEN

Naoki Okamoto
Sep, 2012

RIKEN CDB Retreat Poster Award : First Prize, RIKEN Center for Developmental Biology

Naoki Okamoto
Nov, 2009

Global COE Young Scientist Award (MEXT Global COE program in Nagoya University), Nagoya University

Naoki Okamoto
Dec, 2008

Best Presentation Prize for Under-Forty (The 33rd Annual Meeting of the Japanese Society for Comparative Endocrinology), Japanese Society for Comparative Endocrinology

Naoki Okamoto

Major Papers

Steroid hormone signaling: What we can learn from insect models

Okamoto, Naoki, Fujinaga, Daiki, Yamanaka, Naoki

Vitamins and hormones, 123 525-554, Apr, 2023 Peer-reviewed
Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila

Kosakamoto, Hina, Okamoto, Naoki, Aikawa, Hide, Sugiura, Yuki, Suematsu, Makoto, Niwa, Ryusuke, Miura, Masayuki, Obata, Fumiaki

Nature metabolism, 4(7) 944-959, Jul 1, 2022 Peer-reviewed
Essential functions of mosquito ecdysone importers in development and reproduction

Hun, Lewis V, Okamoto, Naoki, Imura, Eisuke, Maxson, Roilea, Bittar, Riyan, Yamanaka, Naoki

Proceedings of the National Academy of Sciences of the United States of America, 119(25) e2202932119, Jun, 2022 Peer-reviewed
Steroid Hormone Entry into the Brain Requires a Membrane Transporter in Drosophila

Okamoto, Naoki, Yamanaka, Naoki

Current Biology, 30(2) 359-366.e3, Jan, 2020 Peer-reviewedLead author
A specific type of insulin-like peptide regulates the conditional growth of a beetle weapon

Okada, Yasukazu, Katsuki, Masako, Okamoto, Naoki, Fujioka, Haruna, Okada, Kensuke

PLOS Biology, 17(11), Nov, 2019 Peer-reviewed
A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila

Okamoto, Naoki, Viswanatha, Raghuvir, Bittar, Riyan, Li, Zhongchi, Haga-Yamanaka, Sachiko, Perrimon, Norber, Yamanaka, Naoki

Developmental Cell, 47(3) 294-305.e7, Apr, 2018 Peer-reviewedLead author
Signaling from Glia and Cholinergic Neurons Controls Nutrient-Dependent Production of an Insulin-like Peptide for Drosophila Body Growth

Naoki Okamoto, Takashi Nishimura

Developmental Cell, 35(3) 295-310, Nov, 2015 Peer-reviewedLead author
Nutrition-dependent control of insect development by insulin-like peptides

Okamoto, Naoki, Yamanaka, Naoki

Current Opinion in Insect Science, 11 21-30, Oct, 2015 Peer-reviewedLead authorCorresponding author
A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila

N. Okamoto, R. Nakamori, T. Murai, Y. Yamauchi, A. Masuda, T. Nishimura

Genes & Development, 27(1) 87-97, Jan 1, 2013 Peer-reviewedLead author
Conserved role for the Dachshund protein with Drosophila Pax6 homolog eyeless in insulin expression

Naoki Okamoto, Yuka Nishimori, Takashi Nishimura

Proceedings of the National Academy of Sciences of the United States of America, 109(7) 2406-2411, Feb 14, 2012 Peer-reviewedLead author
Spatiotemporal patterns of IGF-like peptide expression in the silkmoth Bombyx mori predict its pleiotropic actions

Naoki Okamoto, Naoki Yamanaka, Yasuhisa Endo, Hiroshi Kataoka, Akira Mizoguchi

General and Comparative Endocrinology, 173(1) 171-182, 2011 Peer-reviewedLead author
A Fat Body-Derived IGF-like Peptide Regulates Postfeeding Growth in Drosophila

Naoki Okamoto, Naoki Yamanaka, Yoshimasa Yagi, Yasuyoshi Nishida, Hiroshi Kataoka, Michael B. O'Connor, Akira Mizoguchi

Developmental Cell, 17(6) 885-891, Dec 15, 2009 Peer-reviewedLead author
An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori

Naoki Okamoto, Naoki Yamanaka, Honoo Satake, Hironao Saegusa, Hiroshi Kataoka, Akira Mizoguchi

FEBS Journal, 276(5) 1221-1232, Mar, 2009 Peer-reviewedLead author

Books and Other Publications

Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition

Okamoto, Naoki (Role: Contributor, Molluscan Insulin-Related Peptides)

Elsevier, Jul, 2021 (ISBN: 9780128206492)
Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition

Okamoto, Naoki (Role: Contributor, Insect Insulin-Like Growth Factor-Like Peptides)

Elsevier, Jul, 2021 (ISBN: 9780128206492)
Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition

Okamoto, Naoki (Role: Contributor, Insect Insulin-Like Growth Factor-Like Peptides)

Elsevier, Jul, 2021 (ISBN: 9780128206492)
Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition

Okamoto, Naoki (Role: Contributor, Insect Insulin-Like Growth Factor-Like Peptides)

Elsevier, Jul, 2021 (ISBN: 9780128206492)
蚕糸・昆虫バイオテック

岡田, 泰和, 岡本, 直樹 (Role: Contributor, オオツノコクヌストモドキにおける武器特異的な栄養応答のメカニズム)

Dec, 2020
Advances in Invertebrate (Neuro)Endocrinology, Volume2: Arthropoda

Okamoto, Naoki, Yamanaka, Naoki (Role: Contributor, Molecular functions of ecdysteroids in insects)

Apple Academic Press, Feb, 2020 (ISBN: 9781771888936)
Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research

Okamoto, Naoki (Role: Contributor, Insect Insulin-Like Growth Factor-Like Peptides)

Elsevier, Sep, 2015 (ISBN: 9780128010280)
Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research

Okamoto, Naoki (Role: Contributor, Molluscan Insulin-Related Peptides)

Elsevier, Sep, 2015 (ISBN: 9780128010280)
Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research

Okamoto, Naoki (Role: Contributor, Molluscan Insulin-Related Peptides)

Elsevier, Sep, 2015 (ISBN: 9780128010280)
Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research

Okamoto, Naoki (Role: Contributor, Insect Insulin-Like Growth Factor-Like Peptides)

Elsevier, Sep, 2015 (ISBN: 9780128010280)
脱皮・変態の生物学−昆虫と甲殻類のホルモン作用の謎を追う

岡本, 直樹, 溝口, 明 (Role: Contributor, 昆虫インスリン様ペプチドの構造と機能)

東海大学出版, May, 2011 (ISBN: 9784486019046)

Presentations

Unraveling the neuroendocrine mechanisms of calcium homeostasis in “bone-less” insects.

Okamoto, Naoki, Mizuno, Yosuke, Niwa, Ryusuke

Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA), 2024 Annual Meeting Invited
Endocrine regulation of calcium homeostasis in Drosophila

Okamoto, Naoki

International Syposium on "Signals for Human, Animal and Planetary Health: From Metabolites To Biological Interactions" Invited
A neuropeptide acts specialized calcium storage organs to regulate calcium homeostasis in Drosophila

Okamoto, Naoki, Mizuno, Yosuke, Kohsaka, Hiroshi, Niwa, Ryusuke

The Asia Pacific Drosophila Neurobiology Conference 3 (APDNC3)
Exploration of Ion transport peptide receptor in the fruit fly Drosophila

Watanabe, Akira, Furumitsu, Megumi, Iwakoshi-Ukena, Eiko, Yoshii, Taishi, Tanimoto, Hiromu, Kondo, Shu, Ukena, Kazuyoshi, Niwa, Ryusuke, Okamoto, Naoki

The Asia Pacific Drosophila Neurobiology Conference 3 (APDNC3)
内分泌系によるカルシウム恒常性の調節機構：ショウジョウバエを用いた研究

岡本, 直樹

第483回発生研セミナー Invited
Developmental adaptation to environment in multicellular organisms

岡本, 直樹, 小幡, 史明

第46回日本分子生物学会年会
昆虫ニコチン性アセチルコリン受容体の先端開拓：サブユニット構成とネオニコチノイド感受性

小森, 勇磨, 高山, 浩一, 岡本, 直樹, 清家, 和樹, 吉成, 祐人, 近藤, 周, 谷本, 拓, 丹羽, 隆介, Sattelle, David B, 松田, 一彦

日本農芸化学会中部・関西支部合同大会
Unraveling the mystery of calcium storage and homeostatic mechanisms in "bone-less” insects

岡本, 直樹

The 5th Morphomeostasis meeting Invited
昆虫の発生を調節する内分泌機構～ショウジョウバエを用いた新規因子の探索と機能解析～

岡本, 直樹

福井県立大・先端セミナー Invited
Endocrine Regulation of Calcium Homeostasis in Drosophila

Okamoto, Naoki, Mizuno, Yosuke, Niwa, Ryusuke

The 6th International Insect Hormone Workshop
"骨"のない昆虫においてカルシウム恒常性を調節する内分泌機構の発見

岡本, 直樹

名古屋大学GTRセミナー Invited
ショウジョウバエのニコチン性アセチルコリン受容体に対するネオニコチノイドの活性を支配する因子

高山, 浩一, 小森, 勇磨, 岡本, 直樹, 吉成, 祐人, 清家, 和樹, 丹羽, 隆介, 伊原, 誠, Sattelle, David B, 松田, 一彦

日本農芸化学会2023年度大会
Neuroendocrine regulation of calcium homeostasis in the fruit fly Drosophila melanogaster

Okamoto, Naoki, Mizuno, Yosuke, Niwa, Ryusuke

第45回日本分子生物学会年会, Nov 30, 2022 Invited
チロシン感知が可能とするタンパク質飢餓をしのぐ適応応答

小坂元, 陽奈, 岡本, 直樹, 丹羽, 隆介, 三浦, 正幸, 小幡, 史明

第45回日本分子生物学会年会, Nov 30, 2022 Invited
Regulation and Function of Nutrient-responsive "Tobidogu"

岡本, 直樹, 小幡, 史明

第45回日本分子生物学会年会
ホルモンによる組織間コミューニケーションを介した発生調節機構：ショウジョウバエを用いた研究

岡本, 直樹

日本植物学会第86回大会, Sep 19, 2022 Invited
Sensing of the non-essential amino acid tyrosine governs the response to dietary protein intake in Drosophila

Kosakamoto, Hina, Okamoto, Naoki, Niwa, Ryusuke, Miura, Masayuki, Obata, Fumiaki

15th Japan Drosophila Research Conference, Sep 12, 2022
Isoform-specific functional analysis of Ion transport peptide and its alternatively spliced variants in Drosophila

Watanabe, Akira, Yoshii, Taishi, Tanimoto, Hiromu, Kondo, Shu, Niwa, Ryusuke, Okamoto, Naoki

15th Japan Drosophila Research Conference, Sep 12, 2022
Endocrine regulation of calcium homeostasis during development

Okamoto, Naoki, Mizuno, Yosuke, Niwa, Ryusuke

15th Japan Drosophila Research Conference, Sep 12, 2022
The expression patterns of ion transport peptide and its alternatively spliced variants imply their pleiotropic functions during development in Drosophila

Watanabe, Akira, Yoshii, Taishi, Tanimoto, Hiromu, Kondo, Shu, Niwa, Ryusuke, Okamoto, Naoki

The 55th Annual Meeting of the Japanese Society for Developmental Biologists, May 31, 2022

Research Projects

全身性カルシウム恒常性メカニズムの追求：個体形状変化をモデル系とした研究

2022年度ライフサイエンス研究助成, 武田科学振興財団, Aug, 2022 - Mar, 2027

岡本直樹
栄養応答性を司る新規内分泌システムの探索

創発的研究支援事業, 科学技術振興機構, Apr, 2023

岡本直樹
Elucidation of the neuroendocrine control of hatching behavior

Grant-in-Aid for Research Activity Start-up, Grant-in-Aid for Research Activity Start-up, University of Tsukuba, Sep, 2020 - Mar, 2022

Naoki Okamoto
Elucidation of the neuroendocrine control of innate behavior during development.

The 10th Tomizawa Jun-ichi & Keiko Fund for Young Scientist, Molecular Biology Society of Japan, May, 2020

Naoki Okamoto
発生タイミングを制御する神経細胞ネットワークとその機能の解明

2014年度内藤記念海外研究留学助成金, 内藤記念科学振興財団, Sep, 2015 - Mar, 2020

岡本直樹
インスリン様ペプチドの産生を制御する栄養シグナル伝達機構の解明

2013年度ライフサイエンス研究奨励, 武田科学振興財団, Aug, 2013 - Mar, 2016

岡本直樹
テナガショウジョウバエ性的二型の分子機構：体サイズと内分泌支配の関係について

科学研究費補助金挑戦的萌芽研究, 日本学術振興会, Apr, 2014 - Aug, 2015

岡本直樹
Study on regulatory mechanisms of the expression and secretion of insulin-like peptides

Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society of for the Promotion of Science, Apr, 2011 - Mar, 2013

Naoki Okamoto

Industrial Property Rights

US10228380B2 Methods for targeting membrane steroid transporters

Yamanaka, Naoki, Yamanaka, Sachiko, Okamoto, Naoki, Bittar, Riyan

Other

原著論文査読（レフリー）： Insect Biochemistry and Molecular Biology, Frontiers in Physiology, PeerJ.

Apr, 2022 - Mar, 2023
原著論文査読（レフリー）：Gene, Insect Biochemistry and Molecular Biology, Genes & Genetic Systems.

Apr, 2021 - Mar, 2022
原著論文査読（レフリ...

Apr, 2021 - Apr, 2021

原著論文査読（レフリー）：Gene, Insect Biochemistry and Molecular Biology, Genes & Genetic Systems.
原著論文査読（レフリ...

Apr, 2021 - Apr, 2021

原著論文査読（レフリー）：Gene, Insect Biochemistry and Molecular Biology.
原著論文査読（レフリー）：Gene, Insects, Insect Biochemistry and Molecular Biology, In vitro cellular & animal developmental biology, Open Biology, PeerJ, PLOS Genetics, Proceedings of the National Academy of Sciences of the USA.

Apr, 2020 - Mar, 2021
原著論文査読（レフリ...

Apr, 2020 - Apr, 2020

原著論文査読（レフリー）：Gene, Insects, Insect Biochemistry and Molecular Biology, In vitro cellular & animal developmental biology, Open Biology, PeerJ, PLOS Genetics, Proceedings of the National Academy of Sciences of the USA.

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