2013年
Evolutionary relationship and structural characterization of the EPF/EPFL gene family.
PloS one
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- 巻
- 8
- 号
- 6
- 開始ページ
- e65183
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1371/journal.pone.0065183
EPF1-EPF2 and EPFL9/Stomagen act antagonistically in regulating leaf stomatal density. The aim of this study was to elucidate the evolutionary functional divergence of EPF/EPFL family genes. Phylogenetic analyses showed that AtEPFL9/Stomagen-like genes are conserved only in vascular plants and are closely related to AtEPF1/EPF2-like genes. Modeling showed that EPF/EPFL peptides share a common 3D structure that is constituted of a scaffold and loop. Molecular dynamics simulation suggested that AtEPF1/EPF2-like peptides form an additional disulfide bond in their loop regions and show greater flexibility in these regions than AtEPFL9/Stomagen-like peptides. This study uncovered the evolutionary relationship and the conformational divergence of proteins encoded by the EPF/EPFL family genes.
- リンク情報
- ID情報
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- DOI : 10.1371/journal.pone.0065183
- ISSN : 1932-6203
- PubMed ID : 23755192
- PubMed Central 記事ID : PMC3670920
- SCOPUS ID : 84878642806