Narumi Hashikawa-Hobara

Profile Information

Affiliation: Faculty of ScienceDepartment of Life Science, Okayama University of Science

Degree: 博士（薬学）(岡山大学)

J-GLOBAL ID: 201801013426686778
researchmap Member ID: B000305115

External link: http://www.dls.ous.ac.jp/staff2/narumi/saito/Top.html

Research Interests

Research Areas

Life sciences / Pharmacology /

Research History

Apr, 2016 - Present

准教授, 理学部臨床生命科学科, 岡山理科大学
Apr, 2008 - Mar, 2016

講師, 理学部臨床生命科学科, 岡山理科大学
Apr, 2006 - Mar, 2008

post doctoral fellow, Weill Cornell Medicine

Education

Apr, 2003 - Mar, 2006

生態機能科学専攻博士後期課程, 自然科学研究科, 岡山大学大学院
Apr, 2001 - Mar, 2003

医療薬学専攻博士前期課程, 自然科学研究科, 岡山大学
Apr, 1997 - Mar, 2001

Department of Pharmaceutics, Tokushima Bunri University

Committee Memberships

2016 - Present

Editorial board member, Scientific Reports, Spring Nature

Awards

Papers

Intranasal calcitonin gene-related peptide administration impairs fear memory retention in mice through the PKD/p-HDAC5/Npas4 pathway.

Narumi Hashikawa-Hobara, Yoshikazu Yoneyama, Kyoushiro Fujiwara, Naoya Hashikawa

Scientific reports, 12(1) 1450-1450, Jan 27, 2022
Evaluation of anxiety-like behavior in calcitonin gene?related peptide KO mice

Kyoshiro, Fujiwara, Yoshikazu, Yoneyama, Shota, Inoue, Naoya, Hashikawa, Narumi, Hashikawa-Hobara

58 1-5, 2022
Lactobacillus paragasseri OLL2809 Improves Depression-Like Behavior and Increases Beneficial Gut Microbes in Mice.

Narumi Hashikawa-Hobara, Ami Otsuka, Chihiro Okujima, Naoya Hashikawa

Frontiers in neuroscience, 16 918953-918953, 2022
Effects from the induction of heat shock proteins in a murine model due to progression of aortic atherosclerosis.

Naoya Hashikawa, Masanobu Ido, Yuna Morita, Narumi Hashikawa-Hobara

Scientific reports, 11(1) 7025-7025, Mar 29, 2021 Peer-reviewed
Npas4 impairs fear memory via phosphorylated HDAC5 induced by CGRP administration in mice.

Narumi Hashikawa-Hobara, Shuta Mishima, Chihiro Okujima, Youdai Shitanishi, Naoya Hashikawa

Scientific reports, 11(1) 7006-7006, Mar 26, 2021 Peer-reviewed
CGRP-overexpressing TG mice showed ataxia without affects to dopaminergic neurons

Yodai, Shitanishi, Shuto, Fuji, Yui, Fujino, Yoshikazu, Yoneyama, Kyoshiro, Fujiwara, Naoya, Hashikawa, Narum, Hashikawa-Hobara

57 1-6, 2021
CGRP overexpression does not alter depression-like behavior in mice.

Narumi Hashikawa-Hobara, Ami Otsuka, Chihiro Okujima, Naoya Hashikawa

PeerJ, 9 e11720, 2021 Peer-reviewed
Oral administration of Eucommia ulmoides Oliv. leaves extract protects against atherosclerosis by improving macrophage function in ApoE knockout mice.

Narumi Hashikawa-Hobara, Naoya Hashikawa, Nao Sugiman, Shingo Hosoo, Tetsuya Hirata, Yasuyo Yamaguchi, Hiroo Yamasaki, Hiromu Kawasaki, Sansei Nishibe

Journal of food science, 85(11) 4018-4024, Nov, 2020 Peer-reviewed
Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice.

Narumi Hashikawa-Hobara, Ami Otsuka, Risa Ishikawa, Naoya Hashikawa

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 118 109263-109263, Oct, 2019 Peer-reviewed
Nerve growth factor (NGF) has an anti-tumor effects through perivascular innervation of neovessels in HT1080 fibrosarcoma and HepG2 hepatitis tumor in nude mice.

Hiromu Kawasaki, Mitsuhiro Goda, Satoko Fukuhara, Narumi Hashikawa-Hobara, Yoshito Zamami, Shingo Takatori

Journal of pharmacological sciences, 140(1) 1-7, May, 2019 Peer-reviewed
Effects of alcoholic beverage treatment on spatial learning and fear memory in mice.

Narumi Hashikawa-Hobara, Shuta Mishima, Shotaro Nagase, Keishi Morita, Ami Otsuka, Naoya Hashikawa

Bioscience, biotechnology, and biochemistry, 82(8) 1417-1424, Aug, 2018 Peer-reviewed
HSP105 prevents depression-like behavior by increasing hippocampal brain-derived neurotrophic factor levels in mice.

Naoya Hashikawa, Yuta Utaka, Takumi Ogawa, Ryo Tanoue, Yuna Morita, Sayumi Yamamoto, Satoru Yamaguchi, Masafumi Kayano, Yoshito Zamami, Narumi Hashikawa-Hobara

Science advances, 3(5) e1603014, May, 2017 Peer-reviewed
Effect of Nerve Growth Factor on Innervation of Perivascular Nerves in Neovasculatures of Mouse Cornea.

Akiko Matsuyama, Shingo Takatori, Yoko Sone, Eiko Ochi, Mitsuhiro Goda, Yoshito Zamami, Narumi Hashikawa-Hobara, Yoshihisa Kitamura, Hiromu Kawasaki

Biological & pharmaceutical bulletin, 40(4) 396-401, 2017 Peer-reviewed
Angiotensin II AT2 receptors regulate NGF-mediated neurite outgrowth via the NO-cGMP pathway.

Narumi Hashikawa-Hobara, Naoya Hashikawa

Biochemical and biophysical research communications, 478(2) 970-5, Sep 16, 2016 Peer-reviewed
The relationship between calcitonin gene-related peptide and depression-like behavior.

Narumi Hashikawa-Hobara, Takumi Ogawa, Yusuke Sakamoto, Naoya Hashikawa

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 148(3) 139-43, Sep, 2016 Peer-reviewed
Nerve growth factor facilitates perivascular innervation in neovasculatures of mice.

Mitsuhiro Goda, Shingo Takatori, Saori Atagi, Narumi Hashikawa-Hobara, Hiromu Kawasaki

Journal of pharmacological sciences, 131(4) 251-8, Aug, 2016 Peer-reviewed
Nerve growth factor facilitates redistribution of adrenergic and non-adrenergic non-cholinergic perivascular nerves injured by phenol in rat mesenteric resistance arteries.

Ayako Yokomizo, Shingo Takatori, Narumi Hashikawa-Hobara, Mitsuhiro Goda, Hiromu Kawasaki

European journal of pharmacology, 770 110-6, Jan 5, 2016 Peer-reviewed
Calcitonin gene-related peptide pre-administration acts as a novel antidepressant in stressed mice.

Narumi Hashikawa-Hobara, Takumi Ogawa, Yusuke Sakamoto, Yumi Matsuo, Mami Ogawa, Yoshito Zamami, Naoya Hashikawa

Scientific reports, 5 12559-12559, Aug 7, 2015 Peer-reviewed
Time Course of Behavioral Alteration and mRNA Levels of Neurotrophic Factor Following Stress Exposure in Mouse.

Naoya Hashikawa, Takumi Ogawa, Yusuke Sakamoto, Mami Ogawa, Yumi Matsuo, Yoshito Zamami, Narumi Hashikawa-Hobara

Cellular and molecular neurobiology, 35(6) 807-17, Aug, 2015 Peer-reviewed
Nicotine facilitates reinnervation of phenol-injured perivascular adrenergic nerves in the rat mesenteric resistance artery.

Shingo Takatori, Hidetoshi Fujiwara, Kenta Hagimori, Narumi Hashikawa-Hobara, Ayako Yokomizo, Fusako Takayama, Panot Tangsucharit, Nobufumi Ono, Hiromu Kawasaki

European journal of pharmacology, 748 1-9, Feb 5, 2015 Peer-reviewed

Misc.

The effects of calcitonin gene-related peptide deficiency on behavior under conditions of social defeat stress in mice

Chihiro Okujima, Youdai Shitanishi, Naoya Hashikawa, Narumi Hashikawa-Hobara

(56) 35-40, 2020
Effects of fear memory in CGRP transgenic mice

Ami Otsuka, Chihiro Okujima, Shinki Ishii, Naoya Hashikawa, Narumi Hashikawa-Hobara

(55) 21-24, 2019
Effects of intracerebroventricular (i.c.v.) administration of CGRP on fear memory in mice

Shuta Mishima, Shota Matsuuchi, Ami Otsuka, Naoya Hashikawa, Narumi Hashikawa

(54) 11-16, 2018
αCGRP Transgenic Mice Display Typical Physiologic Features

Mishima Shuta, Otsuka Ami, Matsuuchi Shota, Hashikawa Naoya, Inoue Kenichi, Hashikawa Narumi

YAKUGAKU ZASSHI, 138(8) 1119-1126, 2018
Effects of time zone and illumination color on the behavioral tests of mice

Sayumi Yamamoto, Ryo Tanoue, Yuna Morita, Narumi Hashikawa, Naoya Hashikawa

(53) 41-45, 2017
Relationship between light intensity and mice behavioral tests

Yuna Morita, Yuta Utaka, Ryo Tanoue, Sayumi Yamamoto, Narumi Hashikawa, Naoya Hashikawa

(52) 51-54, 2016
Effects of 15-day Chronic Stress on Behavior and Neurological Changes in the Hippocampus of ICR Mice

Sakamoto Yusuke, Ogawa Takumi, Ogawa Mami, Matsuo Yumi, Hashikawa Naoya, Hashikawa Narumi

YAKUGAKU ZASSHI, 135(1) 151-158, 2015
Relationship between nicotine administration and depression-like behavior

Ogawa Mami, Sakamoto Yusuke, Ogawa Takumi, Matsuo Yumi, Hashikawa Narumi, Hashikawa Naoya

The bulletin of the Okayama University of Science. A, Natural science, 50(50) 37-40, 2014
幸せホルモン？オキシトシンが母から子に与える影響

橋川成美

ファルマシア, 50(9) 913-913, 2014
抑うつ状態におけるp38MAPKsの作用

橋川成美

日本薬理學雜誌 = Folia pharmacologica Japonica, 140(5) 245-245, Nov 1, 2012
高インスリン血症も末梢神経障害に関与する

橋川成美

日本薬理學雜誌 = Folia pharmacologica Japonica, 140(1) 47-47, Jul 1, 2012
インスリン抵抗性高血圧と血管周囲神経機能変化機序解明への新たなアプローチ

高取真吾, 座間味義人, 橋川成美, 原, 川崎博己

日本薬理学雑誌, 139(2) 70-74, Feb, 2012
ApoEノックアウトマウスにおけるNGFによる神経伸長作用はAkt-NO-cGMP系が関与する

橋川成美, 橋川直也, 由谷親夫, 高取真吾, 川崎博己

日本薬理学雑誌, 138(4) 15P-15P, Oct, 2011
Paracrine control of mesenteric perivascular axo-axonal interaction

H. Kawasaki, S. Takatori, Y. Zamami, T. Koyama, M. Goda, K. Hirai, P. Tangsucharit, X. Jin, N. Hobara, Y. Kitamura

ACTA PHYSIOLOGICA, 203(1) 3-11, Sep, 2011
マウス腸間膜動脈における内皮依存性弛緩反応機序の解析

和家祥大, 牧野堅人, 藤原弘喜, 橋川成美, 橋川直也, 高取真吾, 川崎博己

日本薬理学雑誌, 137(3) 33P-33P, Mar, 2011
ラット摘出脂肪細胞における遊離脂肪酸の放出に及ぼす杜仲葉エキスおよび杜仲葉成分の影響

座間味義人, 橋川成美, 橋川直也, 金シン, 細尾信悟, 平田哲也, 和田篤敬, 高取真吾, 佐々木健二, 川崎博己

日本薬学会年会要旨集, 131年会(3) 202-202, Mar, 2011
Effect of insulin in NGF-mediated neurite outgrowth

Yusuke Inoue, Hayato Asano, Naoya Hashikawa, Narumi Hashikawa

JOURNAL OF PHARMACOLOGICAL SCIENCES, 115 185P-185P, 2011
Effect of angiotensin II type 2 receptors on NGF-mediated neurite outgrowth in apoE knockout mice

Narumi Hashikawa, Naoya Hashikawa, Chikao Yutani, Yoshito Zamami, Shingo Takatori, Mitsunobu Mio, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES, 115 69P-69P, 2011
The inhibitory mechanisms of nerve growth factor (NGF) in mouse tumor growth

Shingo Takatori, Satoko Fukuhara, Mitsuhiro Goda, Narumi Hashikawa, Yoshito Zamami, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES, 115 74P-74P, 2011
マウス腸間膜動脈におけるacetylcholineおよびcalcium ionophore誘発内皮依存性血管弛緩反応の特徴

和家祥大, 牧野堅人, 藤原弘喜, 橋川成美, 橋川直也, 高取真吾, 川崎博己

血管, 34(1) 37-37, Jan, 2011

Teaching Experience

Professional Memberships

Research Projects

CGRP-Npas4経路を介したエピジェネティックな恐怖記憶制御機構の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

橋川成美, 橋川直也
Novel regulatory mechanisms of corneal nerves by acetylcholine in the detection of ocular dryness

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
Searching for PTSD treatments

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Hashikawa-Hobara Narumi, Hashikawa Naoya
The antitumor effects of nerve growth factor on human cancer cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, 2010 - 2011

TAKATORI Shingo, KAWASAKI Hiromu, HASHIKAWA Narumi, GODA Mitsuhiro
Reinnervation and redistribution of perivascular nerves

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

KAWASAKI Hiiromu, KITAMURA Yoshihisa, TAKATORI Shingo, HASHIKAWA Narumi, HINO Hayato

Profile Information

Research Interests

Research Areas

Research History

Education

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Awards

Papers

Misc.

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